Frontiers in Immunology, 2018 The follicular (FO) versus marginal zone (MZ) B cell fate decision in the spleen depends upon BCR, BAFF, and Notch2 signaling. Whether or how Gi signaling affects this fate decision is unknown.
Il-Young Hwang +4 more
doaj +1 more source
Transport of B-Vitamins in Microorganisms. II. Factors Affecting the Uptake of Labelled Thiamine by Nonproliferating Cells of Lactobacillus fermenti. [PDF]
, 1966 Halina Y. Neujahr +7 more
openalex +1 more source
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Scientific Reports, 2017 Thymocyte and T cell trafficking relies on signals initiated by G-protein coupled receptors. To address the importance of the G-proteins Gαi2 and Gαi3 in thymocyte and T cell function, we developed several mouse models.
Il-Young Hwang +3 more
doaj +1 more source
Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design
FEBS Letters, EarlyView.Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos +3 more
wiley +1 more source
Transport of B-Vitamins in Microorganisms. III. Chromatographic Studies on the Radioactivity Extracted from Non-proliferating Cells of Lactobacillus fermenti after Exposure to Labelled Thiamine. [PDF]
, 1966 Halina Y. Neujahr +7 more
openalex +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
iScience, 2023 Summary: CTCF is a DNA-binding protein which plays critical roles in chromatin structure organization and transcriptional regulation; however, little is known about the functional determinants of different CTCF-binding sites (CBS).
Ester Marina-Zárate +4 more
doaj
Transport of B-Vitamins in Microorganisms. V. Comparative Studies on the ATP-hydrolyzing Activities of Cell Fractions Obtained from Thiamine Sufficient and Thiamine Deficient Cells of L. fermenti. [PDF]
, 1966 Halina Y. Neujahr +7 more
openalex +1 more source