Results 31 to 40 of about 1,380,427 (248)

Combined Application of 17𝛽-Estradiol and Progesterone Enhance Vascular Endothelial Growth Factor and Surfactant Protein Expression in Cultured Embryonic Lung Cells of Mice

International Journal of Pediatrics, 2009
Preterm delivery is associated with disruption of the placental supply with 17𝛽-estradiol (E2) and progesterone (P). The aim is to evaluate the role of E2 and P on the regulation of key proteins in lung development in embryonic lung cells.
Andreas Trotter, Markus Kipp, Roland Matthias Schrader, Cordian Beyer   +3 more
doaj   +1 more source

Large collectivity in 29Ne at the boundary of the island of inversion

Physics Letters B, 2023
The heavy-ion inelastic scattering of the neutron-rich nucleus 29Ne to its excited states was studied using a 100.1 MeV/u 29Ne rare isotope beam on 181Ta and 9Be targets. The combined setup consisting of the GRETINA array, the TRIPLEX device and the S800
A. Revel, J. Wu, H. Iwasaki, J. Ash, D. Bazin, B.A. Brown, J. Chen, R. Elder, P. Farris, A. Gade, M. Grinder, N. Kobayashi, J. Li, B. Longfellow, T. Mijatović, J. Pereira, A. Poves, A. Sanchez, N. Shimizu, M. Spieker, Y. Utsuno, D. Weisshaar   +21 more
doaj   +1 more source

The Pt isotopes: comparing the Interacting Boson Model with Configuration Mixing and the Extended Consistent-Q formalism [PDF]

, 2009
The role of intruder configurations in the description of energy spectra and B(E2) values in the Pt region is analyzed. In particular, we study the differences between Interacting Boson Model calculations with or without the inclusion of intruder states ...
Andreyev, Baglin, Baglin, Basunia, Bender, Bender, Bengtsson, Bengtsson, Bijker, Browne, Browne, Brussaard, Caurier, Caurier, Cederwall, Chasman, Cohen, Davidson, De Coster, de Voigt, Dewald, Dracoulis, Dracoulis, Duguet, Duval, Egido, Firestone, Fossion, Fossion, Girod, Goon, Grahn, Grahn, Harder, Hellemans, Hellemans, Heyde, Heyde, Heyde, Heyde, Heyde, Heyde, Hilberath, Iachello, J.E. García-Ramos, Joss, Julin, K. Heyde, King, Kondev, Lawson, Lawson, Lipas, May, McCutchan, McCutchan, McCutchan, Nazarewicz, Oktem, Oros, Page, Pakarinen, Popescu, Reviol, Rodríguez-Guzmán, Sarriguren, Seweryniak, Singh, Singh, Singh, Singh, Singh, Smirnova, Soramel, Stone, Stuchbery, Van de Vel, Warner, Werner, Williams, Wood, Wood, Wood, Wu, Wu, Xu   +85 more
core   +3 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Astrophysical S-factor of the $^7$Be($p,\gamma)^8$B reaction from Coulomb dissociation of $^8$B

, 1996
The Coulomb dissociation method to obtain the astrophysical S-factor, $S_{17}(0)$, for the $^7$Be($p,\gamma)^8$B reaction at solar energies is investigated by analysing the recently measured data on the breakup reaction $^{208}$Pb$(^8$B,$^7$Be$~p)^{208 ...
A.K. Dutt-Mazumder, Alder, Alexio, Bahcall, Bahcall, Barker, Baur, Baur, Bertulani, Bertulani, Buenerd, Filippone, Filippone, Gai, I.J. Thompson, Kavanagh, Kim, Langanke, Langanke, Langanke, Motobayashi, Nakada, R. Shyam, Rolf, Satchler, Shyam, Tombrello, Turck-Chieze, Typel, Vaughn, Xu   +30 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The pharmacokinetic-nephrotoxicity relationships of CMS and CMS-E2 from the perspective of plasma and kidney drug concentrations in rats

Scientific Reports
Nephrotoxicity has seriously affected the clinical application of colistin methanesulphonate (CMS). Colistin B methanesulphonate (CMS-E2) is a novel polymyxin developed and aimed to have lower nephrotoxicity.
Chenxue Guo, Lin Xi, Xingyi Qu, Zhiwei Huang, Size Li, Wanzhen Li, Xiaofen Liu, Jing Zhang   +7 more
doaj   +1 more source

Accuracy of B(E2; 0+ -> 2+) transition rates from intermediate-energy Coulomb excitation experiments

, 2005
The method of intermediate-energy Coulomb excitation has been widely used to determine absolute B(E2; 0+ -> 2+) quadrupole excitation strengths in exotic nuclei with even numbers of protons and neutrons. Transition rates measured with intermediate-energy
A. B. McDonald, A. Bohr, A. Buerger, A. Gade, D. B. Fossan, D. S. Andreev, H. Morinaga, J. M. Cook, K. Alder, O. Hausser, T. Glasmacher, V. M. Khvastunov   +11 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21

eLife, 2018
Cell surface Fc receptors activate inflammation and are tightly controlled to prevent autoimmunity. Antibodies also simulate potent immune signalling from inside the cell via the cytosolic antibody receptor TRIM21, but how this is regulated is unknown ...
Claire Dickson, Adam J Fletcher, Marina Vaysburd, Ji-Chun Yang, Donna L Mallery, Jingwei Zeng, Christopher M Johnson, Stephen H McLaughlin, Mark Skehel, Sarah Maslen, James Cruickshank, Nicolas Huguenin-Dezot, Jason W Chin, David Neuhaus, Leo C James   +14 more
doaj   +1 more source