Results 41 to 50 of about 12,717,037 (234)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Construction and Immunogenicity of Modified Vaccinia Ankara (MVA) Viruses Expressing E1 and E2 Proteins of Bovine Viral Diarrhea Virus

Vaccines
Background/Objectives: Bovine viral diarrhea (BVD) is a major infectious disease of cattle caused by bovine viral diarrhea virus genotypes 1 and 2 (BVDV-1 and BVDV-2).
Yueyang Yu, Xiaohan Yan, Wenge Ma, Yuxin Liu, Zhiyi Liao, Xiaoyu Jiao, Pengpeng Wang, Chen Peng, Baifen Song, Wenxue Wu   +9 more
doaj   +1 more source

Relation between E2 transitions in even–even and odd-mass nuclei [PDF]

EPJ Web of Conferences
How is the B(E2; 2+1 → 0+1) value in an even-even nucleus related to corresponding B(E2; Ji → Jf) values in a neighbouring odd-mass nucleus? If either neutrons or protons are confined to a single- j orbital and if the nucleon-nucleon interaction ...
Van Isacker Piet
doaj   +1 more source

Chikungunya Virus E2 Structural Protein B-Cell Epitopes Analysis

Viruses, 2022
The Togaviridae family comprises a large and diverse group of viruses responsible for recurrent outbreaks in humans. Within this family, the Chikungunya virus (CHIKV) is an important Alphavirus in terms of morbidity, mortality, and economic impact on ...
João Paulo da Cruz Silva, Marielton dos Passos Cunha, Shahab Zaki Pour, Vitor Renaux Hering, Daniel Ferreira de Lima Neto, Paolo Marinho de Andrade Zanotto   +5 more
doaj   +1 more source

Dynamic control of selectivity in the ubiquitination pathway revealed by an ASP to GLU substitution in an intra-molecular salt-bridge network [PDF]

, 2012
Ubiquitination relies on a subtle balance between selectivity and promiscuity achieved through specific interactions between ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s).
Bonvin, Alexandre M. J. J., Sjoerd J de Vries, Adrien S. J. Melquiond (122976), H Th Marc Timmers, Alexandre M. J. J. Bonvin (18079), Adrien S J Melquiond, Wijk, Sjoerd van, Alexandre M J J Bonvin, Melquiond, Adrien S. J., Timmers, H. Th. Marc, Sjoerd J. de Vries (110976), H. Th. Marc Timmers (10936), Sjoerd J. L. van Wijk (122975), Vries, Sjoerd J. de, Sjoerd J L van Wijk   +14 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Efficacy Evaluation of an E2 Subunit Vaccine Against Highly Virulent Classical Swine Fever Virus Strain

Vaccines
Background/Objectives: Classical swine fever (CSF) is listed by the World Organisation for Animal Health as a highly devastating and contagious pig disease, causing severe economic losses to the swine industry.
Yu-Chieh Chen, Chi-Chih Chen, Wen-Bin Chung, Yen-Li Huang, Guan-Ming Ke, Hso-Chi Chaung   +5 more
doaj   +1 more source

e2's Survey on Values and Attitudes 2016

, 2019
Tutkimuksessa selvitettiin suomalaisten näkemyksiä keskusteluilmapiiristä ja sen vaikutuksista osallistumiseen. Samalla kartoitettiin vastaajien näkemyksiä yhteiskunnan ilmapiiristä, demokratiasta, hyvinvoinnista, turvallisuudesta, maahanmuutosta ...
Think Tank e2, Pitkänen, Ville, Westinen, Jussi, e2 ajatuspaja   +3 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Combined Application of 17𝛽-Estradiol and Progesterone Enhance Vascular Endothelial Growth Factor and Surfactant Protein Expression in Cultured Embryonic Lung Cells of Mice

International Journal of Pediatrics, 2009
Preterm delivery is associated with disruption of the placental supply with 17𝛽-estradiol (E2) and progesterone (P). The aim is to evaluate the role of E2 and P on the regulation of key proteins in lung development in embryonic lung cells.
Andreas Trotter, Markus Kipp, Roland Matthias Schrader, Cordian Beyer   +3 more
doaj   +1 more source