Results 41 to 50 of about 270,606 (197)

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21

eLife, 2018
Cell surface Fc receptors activate inflammation and are tightly controlled to prevent autoimmunity. Antibodies also simulate potent immune signalling from inside the cell via the cytosolic antibody receptor TRIM21, but how this is regulated is unknown ...
Claire Dickson, Adam J Fletcher, Marina Vaysburd, Ji-Chun Yang, Donna L Mallery, Jingwei Zeng, Christopher M Johnson, Stephen H McLaughlin, Mark Skehel, Sarah Maslen, James Cruickshank, Nicolas Huguenin-Dezot, Jason W Chin, David Neuhaus, Leo C James   +14 more
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Dihydrotestosterone and 17-Estradiol Enhancement of In Vitro Osteogenic Differentiation of Castrated Male Rat Bone Marrow Mesenchymal Stem Cells (rBMMSCs)

International Journal of Hematology-Oncology and Stem Cell Research, 2019
Background: In vitro impact of dihydrotestosterone (DHT) and 17b-estradiol (E2) in osteogenic differentiation of castrated rat bone marrow mesenchymal stem cells (rBMMSC) still need to be clarified. Materials and Methods: The viability, proliferation and
Faten A.M. Abo-Aziza, A.A. Zaki, Amany S. Amer, Rania A. Lotfy   +3 more
doaj   +1 more source

Impact of Plasma p‐tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Phosphorylated tau181 (p‐tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p‐tau181 in 202 ALS/ALS‐FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics.
Elisabeth Kasper, Annaliis Lehto, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Vogt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Anja Schneider, Stefan Teipel, Johannes Prudlo, Andreas Hermann   +25 more
wiley   +1 more source

Abrupt phase change of the core rotation in the 143Sm nucleus

Physics Letters B, 2018
Dipole sequences in the 143Sm nucleus have been investigated via the 124Sn (24Mg, 5n) reaction at Elab = 107 MeV using the Indian National Gamma Array (INGA).
S. Rajbanshi, R. Raut, H. Pai, Sajad Ali, A. Goswami, G. Gangopadhyay, S. Bhattacharyya, G. Mukherjee, S. Muralithar, R.P. Singh, M. Kumar Raju, P. Singh, R.K. Bhowmik   +12 more
doaj   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

B(E2), B(Ml) and 8(E2/ Ml) of Pt (A=198 & (Z=78) Isotope Using IBM-1

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
Interacting boson model version one has been used in the present theoretical calculations. The energy levels & their transitions for dynamical  symmetry  0(6),  SU(3),  U(5),  ground-state  band,  Beta­ band, Gamma  band, B(E2), Ot, B(Ml), ,u,gt and
K.S Ibraheim, I TAI-Aiawy, H.T Sulaiman
doaj  

Characterization of a Lipoyl Domain-Independent B-Cell Autoepitope on the Human Branched-Chain Acyltransferase in Primary Biliary Cirrhosis and Overlap Syndrome with Autoimmune Hepatitis

Clinical and Developmental Immunology, 2003
Background and aims: Antimitochondrial antibodies (AMA) which recognize pyruvate acetyltransferase (PDC-E2) represent a highly diagnostic feature of primary biliary cirrhosis (PBC).
Antal Csepregi, Petra Obermayer-Straub, Susanne Kneip, Anne Kayser, Stephanie Loges, Eleonore Schmidt, Elemér Nemesánszky, Ferenc Szalay, Michael P. Manns, Christian P. Strassburg   +9 more
doaj   +1 more source

ICI 182,780 has agonistic effects and synergizes with estradiol-17 beta in fish liver, but not in testis

Reproductive Biology and Endocrinology, 2006
Background ICI 182,780 (ICI) belongs to a new class of antiestrogens developed to be pure estrogen antagonists and, in addition to its therapeutic use, it has been used to knock-out estrogen and estrogen receptor (ER) actions in several mammalian species.
Power Deborah M, Teodósio Helena R, Condeça João B, Singh Pratap B, Pinto Patrícia, Canário Adelino   +5 more
doaj   +1 more source

Applying Nuclear Shell Model to Study Nuclear Structure for 18Ne by Using OXBASH Code

Journal of Kufa-Physics, 2020
In this study, the shell model used to calculate energy levels and reduced electric quadruple transition probability B(E2)  for 18Ne isotope using OXBASH code within the sd shell and using the KUOSD effective interaction.18Ne isotope contain two proton ...
Hadeel H. Abed, Ali k. Hasan
doaj   +1 more source