Results 41 to 50 of about 288,045 (238)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Combined Application of 17𝛽-Estradiol and Progesterone Enhance Vascular Endothelial Growth Factor and Surfactant Protein Expression in Cultured Embryonic Lung Cells of Mice

International Journal of Pediatrics, 2009
Preterm delivery is associated with disruption of the placental supply with 17𝛽-estradiol (E2) and progesterone (P). The aim is to evaluate the role of E2 and P on the regulation of key proteins in lung development in embryonic lung cells.
Andreas Trotter, Markus Kipp, Roland Matthias Schrader, Cordian Beyer   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The pharmacokinetic-nephrotoxicity relationships of CMS and CMS-E2 from the perspective of plasma and kidney drug concentrations in rats

Scientific Reports
Nephrotoxicity has seriously affected the clinical application of colistin methanesulphonate (CMS). Colistin B methanesulphonate (CMS-E2) is a novel polymyxin developed and aimed to have lower nephrotoxicity.
Chenxue Guo, Lin Xi, Xingyi Qu, Zhiwei Huang, Size Li, Wanzhen Li, Xiaofen Liu, Jing Zhang   +7 more
doaj   +1 more source

Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominantly through the B domain of the E2 glycoprotein.

PLoS Neglected Tropical Diseases, 2023
Infections with Chikungunya virus, a mosquito-borne alphavirus, cause an acute febrile syndrome often followed by chronic arthritis that persists for months to years post-infection.
John M Powers, Zoe L Lyski, Whitney C Weber, Michael Denton, Magdalene M Streblow, Adam T Mayo, Nicole N Haese, Chad D Nix, Rachel Rodríguez-Santiago, Luisa I Alvarado, Vanessa Rivera-Amill, William B Messer, Daniel N Streblow   +12 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Of these, the upstream promoter was activated by E2 in 25 genes (A), and was inactivated by E2 in 61 cases (B)

, 2011
The downstream promoter was activated by E2 treatment in 62 cases (C), and inactivated by E2 in 64 cases (D).Copyright information:Taken from "Genome-wide analysis of alternative promoters of human genes using a custom promoter tiling array"http://www ...
Gregory AC Singer (6276), Christoph Plass (14626), Tim HM Huang (65348), Jiejun Wu (65346), Pearlly Yan (65347), Ramana V Davuluri (17597)   +5 more
core   +1 more source

The fanconi anemia DNA repair pathway is regulated by an interaction between ubiquitin and the E2-like fold domain of FANCL [PDF]

, 2015
The Fanconi Anemia (FA) DNA repair pathway is essential for the recognition and repair of DNA interstrand crosslinks (ICL). Inefficient repair of these ICL can lead to leukemia and bone marrow failure.
Howard, Mark J., Sidhu, Ateesh, Chaugule, Viduth K., Alpi, Arno F., Miles, Jennifer A., Carroll, Eilis, Frost, Mark G., Rowe, Michelle L., Walden, Helen   +8 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Large collectivity in 29Ne at the boundary of the island of inversion

Physics Letters B, 2023
The heavy-ion inelastic scattering of the neutron-rich nucleus 29Ne to its excited states was studied using a 100.1 MeV/u 29Ne rare isotope beam on 181Ta and 9Be targets. The combined setup consisting of the GRETINA array, the TRIPLEX device and the S800
A. Revel, J. Wu, H. Iwasaki, J. Ash, D. Bazin, B.A. Brown, J. Chen, R. Elder, P. Farris, A. Gade, M. Grinder, N. Kobayashi, J. Li, B. Longfellow, T. Mijatović, J. Pereira, A. Poves, A. Sanchez, N. Shimizu, M. Spieker, Y. Utsuno, D. Weisshaar   +21 more
doaj   +1 more source