Results 51 to 60 of about 20,375,797 (310)
Inequalities in Health Status from EQ-5D Findings: A Cross-Sectional Study in Low-Income Communities of Bangladesh [PDF]
International Journal of Health Policy and Management, 2016 Background Measuring health status by using standardized and validated instrument has become a growing concern over the past few decades throughout the developed and developing countries.
Marufa Sultana +8 more
doaj +1 more source
, 2004 This was the second session that 6th grade students from the Plainfield, NJ district explored probability through dice games in an after-school enrichment program.
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
European Journal of Medicinal Chemistry ReportsAs a part of the Illuminating the Druggable Genome initiative, the U.S. National Institutes of Health (NIH), identified 162 understudied human protein and lipid kinases forming the “dark” kinome. In protein kinase (PK) drug discovery, the dark kinome has
Selina Koch +2 more
doaj +1 more source
, 2004 Middle school students discuss their ideas after using Probability Explorer to solve several tasks. The ideas allude to early concepts of experimental and theoretical probability.
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
European Journal of Medicinal Chemistry ReportsChemical language models (CLMs) are increasingly used for generative design of candidate compounds for medicinal chemistry. However, their predictions are difficult to rationalize.
Sanjana Srinivasan +2 more
doaj +1 more source
, 2004 This was the first session that 6th grade students from the Plainfield, NJ district explored probability through dice games in an after-school enrichment program. The first Dice game was introduced by researcher Arthur Powell. This video (43a, part 2 of
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Transcutaneous vagus nerve stimulation effects on chronic pain: systematic review and meta-analysis
PAIN Reports. Chronic pain is one of the major causes of disability with a tremendous impact on an individual's quality of life and on public health. Transcutaneous vagus nerve stimulation (tVNS) is a safe therapeutic for this condition.
Valton Costa +9 more
doaj +1 more source