Results 41 to 50 of about 20,375,797 (310)
Comprehensive Data-Driven Assessment of Non-Kinase Targets of Inhibitors of the Human Kinome
BiomoleculesProtein kinases (PKs) are involved in many intracellular signal transduction pathways through phosphorylation cascades and have become intensely investigated pharmaceutical targets over the past two decades.
Mona Mobasher +3 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin +2 more
wiley +1 more source
Journal of CheminformaticsDeep learning models adapted from natural language processing offer new opportunities for the prediction of active compounds via machine translation of sequential molecular data representations. For example, chemical language models are often derived for
Hengwei Chen, Jürgen Bajorath
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Advanced Analysis of Electroretinograms Based on Wavelet Scalogram Processing
Applied Sciences, 2022 The electroretinography (ERG) is a diagnostic test that measures the electrical activity of the retina in response to a light stimulus. The current ERG signal analysis uses four components, namely amplitude, and the latency of a-wave and b-wave. Nowadays,
Aleksei Zhdanov +4 more
doaj +1 more source
B-Learning Tools in Engineering Education
International Journal of Engineering Pedagogy (iJEP), 2013 <!--[if gte mso 9]><xml> <o:OfficeDocumentSettings> <o:AllowPNG /> </o:OfficeDocumentSettings> </xml><![endif]--><!--[if gte mso 9]><xml> <w:WordDocument> <w:Zoom>0</w:Zoom> <w:TrackMoves>false</w:TrackMoves> <w:TrackFormatting /> <w:HyphenationZone>21</w:
Angeles Cancela +3 more
openaire +2 more sources
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
ABSTRACTThe transformation of higher education in South Africa has tended to focus on issues such as access and representation, leaving curricula insufficiently addressed. This is surprising, considering that much previous scholarship, including the recent Khampepe Report, has called for the implementation of a specific pedagogical framework to foster ...
Andrews, Ruth +2 more
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source