Results 81 to 90 of about 13,560,698 (307)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

The electrocurrent microrelay modelling

open access: yesТехнологія та конструювання в електронній апаратурі, 2011
The design and method of electrocurrent microrelay theoretical modelling is offered. It is established, that base function in the normalized kind graphically represents a symmetric parabola.
N. I. Mukhurov   +2 more
doaj  

New Physics in inclusive semileptonic B decays

open access: yesJournal of High Energy Physics
We study inclusive semileptonic $$\overline{B}\to {X }_{c}{\ell}\overline{\nu }$$ decays (ℓ = e, μ) in the presence of generic physics Beyond the Standard Model (BSM) that is heavy compared to the b-quark mass.
Alexandre Carvunis   +4 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Method of stationary interference patterns reading and processing

open access: yesТехнологія та конструювання в електронній апаратурі, 2009
The optoelectronic reading system enables real-time acquisition and processing of interference pattern images in the Kesterse interferometer with sufficient resolution. The root-mean-square deviation of the measurement results is 0.001 mm. The total time
V. N. Ilyin   +2 more
doaj  

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

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