Results 81 to 90 of about 446,011 (218)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Inclusive and differential cross section measurements of t t ¯ b b ¯ $$ \textrm{t}\overline{\textrm{t}}\textrm{b}\overline{\textrm{b}} $$ production in the lepton+jets channel at s $$ \sqrt{s} $$ = 13 TeV

open access: yesJournal of High Energy Physics
Measurements of inclusive and normalized differential cross sections of the associated production of top quark-antiquark and bottom quark-antiquark pairs, t t ¯ b b ¯ $$ \textrm{t}\overline{\textrm{t}}\textrm{b}\overline{\textrm{b}} $$ , are presented ...
The CMS collaboration   +2362 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Measurement of the Higgs boson production via vector boson fusion and its decay into bottom quarks in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV

open access: yesJournal of High Energy Physics
A measurement of the Higgs boson (H) production via vector boson fusion (VBF) and its decay into a bottom quark-antiquark pair ( b b ¯ $$ \textrm{b}\overline{\textrm{b}} $$ ) is presented using proton-proton collision data recorded by the CMS experiment ...
The CMS collaboration   +2325 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Search for the decay B 0 → ϕϕ

open access: yesJournal of High Energy Physics
A search for the decay B 0 → ϕϕ is made using pp collision data collected with the LHCb detector at centre-of-mass energies of 7, 8 and 13 TeV, corresponding to an integrated luminosity of 9 fb −1. No significant signal is observed, and an upper limit on
The LHCb collaboration   +1187 more
doaj   +1 more source

Imprints of new physics operators in the semileptonic B→a1(1260)ℓ−ν¯ℓ process in SMEFT approach

open access: yesPhysics Letters B
At present, there are several measurements of B decays that exhibit discrepancies with the predictions of the Standard Model, and suggest the presence of new physics in b→s and b→c(u) quark level transitions.
Manas Kumar Mohapatra   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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