Results 281 to 290 of about 840,514 (343)

New Structure Activity Relationship Insight into the Role of the C‐3 Extension on Rifamycin Antimycobacterial Activity

open access: yesChemMedChem, EarlyView.
Rifamycin analogues with variably functionalized C‐3 extensions provide new insight into the role of this region for MTb inhibitory activity. In addition to potentially optimizing target engagement, this region can also be used to modulate physicochemical properties, an important consideration for optimizing antimycobacterial activity.
Clinton G. L. Veale   +4 more
wiley   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

open access: yesChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Understanding pathogen transmission on inanimate surfaces: Insights from respiratory fluid droplet composition and drying dynamics

open access: yesDroplet, EarlyView.
The graphical abstract shows the various phenomena the droplet undergo during evaporation, precipitation, and transfer to susceptible host. Abstract This study investigates how pathogen‐laden respiratory droplets transfer diseases via inanimate surfaces.
Abdur Rasheed   +5 more
wiley   +1 more source

1,3‐Diazetidin‐2‐Ones: Synthetic Approaches and Therapeutic Promise within the Aza‐β‐Lactam Family

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
This review explores the synthesis, reactivity, and therapeutic potential of 1,3‐diazetidin‐2‐ones—an underexplored class of aza‐β‐lactams. Emphasis is placed on synthetic challenges, emerging methodologies, and their promise as β‐lactamase‐resistant scaffolds in medicinal chemistry. 1,3‐diazetidin‐2‐ones, overlooked members of the aza‐β‐lactam family,
Jozef Kristek, Jiří Pospíšil
wiley   +1 more source

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