Results 61 to 70 of about 301,409 (298)

How to change the oligomeric state of a circular protein assembly: switch from 11-subunit to 12-subunit TRAP suggests a general mechanism [PDF]

, 2011
Many critical cellular functions are performed by multisubunit circular protein oligomers whose internal geometry has evolved to meet functional requirements.
Antson, Alfred A, Antson, A., Merlino, N., Natalie Merlino, Chen, Chao-Sheng, Guy G. Dodson, Merlino, Natalie, Alfred A Antson, Dodson, Guy G, Shevtsov, Mikhail B, Dodson, G., Paul Gollnick, Gollnick, Paul, Alfred A. Antson, Shevtsov, Misha, Chao-Sheng Chen, Smits, Callum, Mikhail B Shevtsov, Smits, C., Callum Smits, Mikhail B. Shevtsov, Guy G Dodson, Gollnick, P., Chen, C.   +23 more
core   +2 more sources

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

Should I Stay or Should I Go—Leveraging an Overlooked Feature of Click‐to‐Release Chemistry for Affinity Labeling

Angewandte Chemie, EarlyView.
Click‐to‐release (C2R) chemistry is redirected from payload liberation toward ligand‐directed covalent protein labeling through a transient dihydropyridazine methide (DHP‐methide). This concept opens the way to dual‐functional systems combining covalent target engagement with controlled effector release.
Dóra Kern, Krisztina Németh, Tímea Imre, József Simon, Kitti Meggyes, Gergő Bárdos, László Petri, Márton Bojtár, Attila Kormos, Péter Kele   +9 more
wiley   +2 more sources

Effects of Bacillus subtilis on cotton physiology and growth under water and salt stress

Agricultural Water Management
The scarcity of fresh water resources has severely limited agricultural production in arid areas. Although brackish water irrigation or fresh water deficit irrigation can alleviate the water resources crisis, both may cause water and salt stress to crop.
Yanpeng Bi, Beibei Zhou, Peiqi Ren, Xiaopeng Chen, Dehua Zhou, Shaoxiong Yao, Dongliang Fan, Xiaolong Chen   +7 more
doaj   +1 more source

Computation‐Guided Tunnel Engineering Enhances O2 Transport and H2O2 Resistance of Fe(II)/α‐Ketoglutarate‐Dependent Dioxygenases

Advanced Science, EarlyView.
This study presents a computational tunnel engineering strategy in Fe(II)/α‐ketoglutarate‐dependent dioxygenases (αKGDs) to enhance oxygen (O2) transport, an essential molecule for αKGDs, and limit hydrogen peroxide (H2O2) entry, an inhibitor from the αKG supply system.
Huan Liu, Lunjie Wu, Liying Mao, Songyin Zhao, Hu Liu, Shiyi Xin, Donglin Zhao, Jie Gu, Yan Xu, Xinye Wang, Yao Nie   +10 more
wiley   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

Spectinomycin dependence in Bacillus subtilis [PDF]

Journal of Bacteriology, 1979
Spectinomycin dependence in Bacillus subtilis involves two mutations, one conferring drug resistance and the other producing a requirement for spectinomycin for growth.
T M, Henkin, K M, Campbell, G H, Chambliss   +2 more
openaire   +2 more sources

Construction of Plasmid Cloning Vectors for Lactic Streptococci Which Also Replicate in Bacillus subtilis and Escherichia coli [PDF]

, 1984
The cryptic Streptococcus cremoris Wg2 plasmid pWV01 (1.5 megadaltons) was genetically marked with the chloramphenicol resistance (Cmr) gene from pC194.
Venema, Gerard,, Kok, Jan, Kok, Jan,, Vossen, Jos M.B.M. van der, Venema, Gerhardus, Vossen, Jos M.B.M. van der,   +5 more
core  

TLM-Quant : an open-source pipeline for visualization and quantification of gene expression heterogeneity in growing microbial cells [PDF]

, 2013
Gene expression heterogeneity is a key driver for microbial adaptation to fluctuating environmental conditions, cell differentiation and the evolution of species. This phenomenon has therefore enormous implications, not only for life in general, but also
Piersma, Sjouke, Sjouke Piersma (434244), Rudi H J Tonk, Emma L. Denham (121430), Jan Maarten van Dijl, Tonk Rudi H. J., Jan Maarten van Dijl (90770), Samuel Drulhe, Schwikowski Benno, Denham, Emma, Schwikowski, Benno, Piersma Sjouke, Drulhe, Samuel, Drulhe Samuel, Denham, Emma L., van Dijl, Jan Maarten, van Dijl Jan Maarten, Sjouke Piersma, Dijl, Jan Maarten van, Benno Schwikowski (434247), Tonk, Rudi H. J., Rudi H. J. Tonk (434246), Samuel Drulhe (434245), Benno Schwikowski, Emma L Denham, Denham Emma L.   +25 more
core   +3 more sources

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source