Results 91 to 100 of about 2,596,942 (309)

A constitutive model with damage for high temperature superalloys [PDF]

A unified constitutive model is searched for that is applicable for high temperature superalloys used in modern gas turbines. Two unified inelastic state variable constitutive models were evaluated for use with the damage parameter proposed by Kachanov ...
Sherwood, J. A., Stouffer, D. C.
core   +1 more source

Spanish Football [PDF]

, 2006
The authors analyze the financial situation of the Spanish football industry. They first argue that a relevant analysis of the industry's financial results relies on a careful description of how historical and cultural factors have influenced its ...
Ascari, Guido, Gagnepain, Philippe
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A New Stored Energy Model Based on Plastic Work of Back Stress during Cyclic Loading in Polycrystalline Metal. [PDF]

Materials (Basel), 2022
Xu H, Li X, Li W, Jiang P, Zhao Y, Liu Y.   +5 more
europepmc   +1 more source

Bounds on internal state variables in viscoplasticity [PDF]

A typical viscoplastic model will introduce up to three types of internal state variables in order to properly describe transient material behavior; they are as follows: the back stress, the yield stress, and the drag strength.
Freed, Alan D.
core   +1 more source

Applying stress-testing on value at risk (VaR) methodologies [PDF]

, 2004
In recent years, Value at Risk (VaR) methodologies, i. e., Parametric VaR, Historical Simulation and the Monte Carlo Simulation have experienced spectacular growth within the new regulatory framework which is Basle II.
Feria Domínguez, José Manuel, Oliver Alfonso, María Dolores   +1 more
core   +1 more source

Back reaction in the formation of a straight cosmic string [PDF]

, 1995
A simple model for the formation of a straight cosmic string, wiggly or unperturbed is considered. The gravitational field of such string is computed in the linear approximation.
A. Campos, A. Vilenkin, A. Vilenkin, A. Vilenkin, A.A. Starobinsky, A.H. Zemanian, Antonio Campos, B. Allen, B. Carter, B. Linet, B. Linet, D. Garfinkle, D.N. Vollick, D.P. Bennet, E. Copeland, Enric Verdaguer, F.D. Mazzitelli, G. Mendell, G.T. Horowitz, G.T. Horowitz, G.T. Horowitz, H. Ford, J. Garriga, J. Traschen, J. Traschen, J.C.R. Magueijo, J.R. Gott III, L. Parker, P.C.W. Davies, R.D. Jordan, R.H.B. Brandenberger, Rosario Martín, S. Veeraraghavan, T. Vachaspati, T.M. Helliwell, T.W.B. Kibble, V. Husain, V. Sahni, W.A. Hiscock, W.A. Hiscock   +39 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Potential of oil-lubricated cylindrical plastic gears

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
Bending strength of injection molded polyacetal test gears is investigated in back-to-back testing using oil-lubrication. To validate state of the art calculation methods, tooth geometries with a variable number of teeth are investigated, maintaining a ...
Christian HASL, Christopher ILLENBERGER, Peter OSTER, Thomas TOBIE, Karsten STAHL   +4 more
doaj   +1 more source

Anisotropic yield functions in a co-rotating reference frame [PDF]

, 2000
In metal forming simulations large deformations are often treated based on objective formulations. Large rotations are accounted for by rotating the stress tensor or approximating the rotation by some integration rule for the rate of rotation.
Boogaard, A.H. van den, Huetink, J., Pijlman, H.H.   +2 more
core   +1 more source