Results 111 to 120 of about 2,596,942 (309)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Photoelastic analysis of stress generated by Connecticut Intrusion Arch (CIA)

Dental Press Journal of Orthodontics
Objective: The present in vitro study evaluated, by means of the photoelastic technique, the effects generated by the Connecticut Intrusion Arch (CIA), with a 90o bend on the distal surface of molar tubes and using the 4 x 2 appliance on the anterior ...
Alessandro Schwertner, Renato Rodrigues de Almeida, Alcides Gonini Jr, Marcio Rodrigues de Almeida   +3 more
doaj   +1 more source

On the dynamics of mechanical failures in magnetized neutron-star crusts

, 2012
We consider the dynamics of a mechanical failure induced by a shear stress in a strongly magnetized neutron-star crust. We show that even if the elastic properties of the crust allow the creation of a shear crack, the strongly sheared magnetic field ...
Ashby, Blaes, Bridgeman, Chamel, Chugunov, Goldreich, Horowitz, Jones, Kostrov, Landau, Levin, Link, Lyutikov, Lyutikov, Maxim Lyutikov, Molinari, Perna, Pons, Thompson, Thompson, Woods, Yuri Levin   +21 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Quantum Stress-Tensor in Self-Similar Spherical Dust Collapse

, 1998
We calculate the quantum stress tensor for a massless scalar field in the 2-d self-similar spherical dust collapse model which admits a naked singularity. We find that the outgoing radiation flux diverges on the Cauchy horizon.
A. Ori, C. J. S. Clarke, C. Vaz, C. Vaz, C. Vaz, Cenalo Vaz, L. D. Landau, L. H. Ford, Louis Witten, N. D. Birrell, P. C. W. Davies, P. S. Joshi, P. S. Joshi, R. M. Wald, R. Penrose, Sukratu Barve, T. P. Singh, T. P. Singh, T. P. Singh, W. A. Hiscock   +19 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Development of a continuum plasticity model for the commercial finite element code ABAQUS [PDF]

, 2011
The present work relates to the development of computational material models for sheet metal forming simulations. In this specific study, an implicit scheme with consistent Jacobian is used for integration of large deformation formulation and plane ...
De Waele, Wim, Safaei, Mohsen
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Magnitude of low back pain and associated factors among primary school teachers in Borama City, Somaliland: an institutional-based cross-sectional study

BMJ Open
Objectives The goal of the study was to determine the magnitude and contributing factors of low back pain among primary school teachers in Borama Town, Somaliland.Design An institution-based descriptive cross-sectional study design was employed.
Seid Yimam Ali, Mekonin Meskelu Shegere, Ahmed Moumin Abdilahi, Najah Bouh Farah, Bilan Abdi Adem, Asma Jemal Nour   +5 more
doaj   +1 more source