Results 41 to 50 of about 8,740 (203)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

<b>Atividade antimicrobiana dos óleos essenciais de erva-cidreira e manjericão frente a bactérias de carnes bovinas<br>Antimicrobial activity of essential oils of cidreira-herb and basil against bacteria from bovine meat</b>

Alimentos e Nutrição, 2011
<p align="justify"> O presente trabalho teve como objetivo avaliar a atividade antimicrobiana, in vitro, dos óleos essenciais extraídos de Lippia alba (Mill) N. E. Brown e Ocimum basilicum frente a microrganismos isolados de carnes bovinas. Os óleos foram extraídos por hidrodestilação e caracterizados quanto à composição por cromatograï¬
G. G. SANTOS, R. C. TRINDADE, J. A. B. ALVES, P. O. SANTOS, P. B. ALVES, A. F. BLANK, L. M. CARVALHO, L. C. L. AQUINO   +7 more
openaire   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

FORMIGAS ANDARILHAS COMO VETORES MECÂNICOS DE MICRORGANISMOS

Revista UniVap, 2017
Artrópodes são abundantes em ambientes urbanizados, porém pouco se sabe sobre como esses animais vêm respondendo aos processos de mudança dos grandes centros urbanos.
Cheynne Marçal de Souza, Nádia Maria Rodrigues de Campos Velho   +1 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Bactérias transportadas em mutucas (Diptera: Tabanidae) no nordeste do estado do Pará, Brasil

Boletim do Museu Paraense Emílio Goeldi. Ciências Naturais, 2007
Os insetos da família Tabanidae (Diptera), conhecidos vulgarmente como mutucas, são considerados potenciais pragas ao homem e animais domésticos pelo comportamento hematófago de suas fêmeas.
Willy Cristiano Luz-Alves, Inocêncio de Sousa Gorayeb, José Caetano Lima Silva, Edvaldo Carlos Brito Loureiro   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

INFECÇÃO BACTERIANA HOSPITALAR EM PACIENTES SUBMETIDOS A TRANSPLANTE HEPÁTICO EM 2008

Revista de Pesquisa Cuidado é Fundamental Online, 2010
INTRODUÇÃO: A infecção hospitalar representa um grave problema de saúde pública. É definido como aquela adquirida no hospital que se manifesta após 72 horas de internação ou mesmo após a sua alta, desde que se relacione com o período de internamento Mies
Maria Ozilene Rodrigues Batista, Maria Cristina Leite Araújo Borges, Ocilia Maria Costa Carvalho, Ana Maria Maia Rodrigues, Jaqueline Gomes de Souza Santos   +4 more
doaj   +2 more sources