Results 71 to 80 of about 3,245,210 (307)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Heterogeneous microbial community associated with Bursaphelenchus xylophilus [PDF]

, 2012
Pine wilt disease (PWD) is a complex disease integrating three major factors: the causal agent, the pinewood nematode Bursaphelenchus xylophilus; the insect-vector Monochamus spp.; and the host pine tree, Pinus sp.
Barbosa, Pedro, Espada, Margarida, Glick, B, Mota, Manuel, Nascimento, Francisco, Oliveira, Solange, Vicente, Cláudia   +6 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Chronic Wounds: The Persistent Infection Problem [PDF]

, 2013
Chronic wounds heal poorly and can have a huge impact on a sufferer’s life. They are caused by a number of factors, one of which is the presence of persistent infections.
Davis, NG
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Uneven distribution of cobamide biosynthesis and dependence in bacteria predicted by comparative genomics. [PDF]

, 2019
The vitamin B12 family of cofactors known as cobamides are essential for a variety of microbial metabolisms. We used comparative genomics of 11,000 bacterial species to analyze the extent and distribution of cobamide production and use across bacteria ...
Haft, David R, Han, Andrew W, Jackson, Samantha N, Mok, Kenny C, Seth, Erica C, Shelton, Amanda N, Taga, Michiko E   +6 more
core   +1 more source

Allelic Variation in gtfB–gtfC Region of Natural Variant of Streptococcus mutans Without Biofilm Formation

Bacteria
Streptococcus mutans is primarily found in biofilms on tooth surfaces and is associated with the development of dental caries. S. mutans synthesizes water-insoluble glucan (WIG) using sucrose as a substrate, inducing the formation of three-dimensional ...
Manami Kimijima, Naoki Narisawa, Tomoyo Nakagawa-Nakamura, Hidenobu Senpuku   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Integrated microfluidic tmRNA purification and real-time NASBA device for molecular diagnostics. [PDF]

, 2008
We demonstrate the first integrated microfluidic tmRNA purification and nucleic acid sequence-based amplification (NASBA) device incorporating real-time detection.
Antonio J. Ricco, Breadmore, Bryan Lincoln, Cady, Caroline Viguier, Chen, Chen, Chung, Claus R. Poulsen, Compton, Cremonesi, Dittrich, Easley, Fu-Chun Huang, Glynn, Glynn, Gulliksen, Gulliksen, Ivan K. Dimov, Jaykus, Jose L. Garcia-Cordero, Justin O'Grady, Keiler, Khandurina, Lee, Lee, Legendre, Leone, Lien, Linder, Liu, Lorcan Kent, Luke P. Lee, Majella Maher, Monis, Nagrath, O' Grady, Paul Daly, Richard O'Kennedy, Sia, Terry J. Smith, Toriello, Tyagi, Tyagi, Tyagi, Waters, Younan Xia, Zhang, Zhang   +48 more
core   +1 more source

Light-controlled bacteria-surface and bacteria-bacteria adhesions

, 2019
In bacterial biofilms, collective functions arise from the social interactions and spatial organization of bacteria. Controlling bacterial adhesion as key steps in biofilm formation with high spatial and temporal precision is essential for controlling the formation, organization and microstructure of biofilms.
openaire   +4 more sources