Results 61 to 70 of about 6,595 (270)
Physical Determinants of Amyloid Assembly in Biofilm Formation
mBio, 2019 A wide range of bacterial pathogens have been shown to form biofilms, which significantly increase their resistance to environmental stresses, such as antibiotics, and are thus of central importance in the context of bacterial diseases.
Maria Andreasen +9 more
doaj +1 more source
Biomimetics, 2023 Since the proposal of the brainstem axis theory, increasing research attention has been paid to the interactions between bacterial amyloids produced by intestinal flora and the amyloid β−protein (Aβ) related to Alzheimer’s disease (AD), and it has been ...
Bushu Peng +4 more
doaj +1 more source
Engineering protein self-assembling in protein-based nanomedicines for drug delivery and gene therapy [PDF]
, 2015 Altres ajuts: FISS/PS09-00165Altres ajuts: FISS/PI12-00327Lack of targeting and improper biodistribution are major flaws in current drug-based therapies that prevent reaching high local concentrations of the therapeutic agent.
Corchero Nieto, José Luis +5 more
core +2 more sources
Structural analysis of the bacterial amyloid curli [PDF]
, 2022 AbstractTwo decades have passed since the initial proposition that amyloids are not only (toxic) byproducts of an unintended aggregation cascade, but that they can also be produced by an organism to serve a defined biological function. That revolutionary idea was borne out of the realization that a large fraction of the extracellular matrix that holds ...
Mike Sleutel +2 more
openaire +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
BBA Advances, 2022 Functional amyloids (FA) are proteins which are evolutionarily optimized to form highly stable fibrillar structures that strengthen the bacterial biofilm matrix. FA such as CsgA (E. coli) and FapC (Pseudomonas) are secreted to the bacterial surface where
Zahra Najarzadeh +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
IEEE Access, 2022 This paper presents a model that describes a possible mechanism for electromagnetic (EM) signal transmission and reception by bacterial cells within their biofilm communities.
Navid Barani +6 more
doaj +1 more source
Bacterial Inclusion Bodies Contain Amyloid-Like Structure
PLoS Biology, 2008 PLoS Biology, 6 (8)
Wang, Lei +4 more
openaire +5 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source