Results 51 to 60 of about 11,136,295 (320)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

One-pot, uracil-DNA-glycosylase-aided, and multi-indicator nanobiosensor detection platform for identifying Brucella melitensis from the Brucella spp

BMC Microbiology
Background Brucellosis, a zoonotic chronic contagious disease caused by Brucella spp., is primarily associated with species such as Brucella melitensis (B. melitensis) and B. abortus, among which B.
Xinggui Yang, Yue Wang, Sha Mao, Ying Liu, Fengming Chen, Junfei Huang, Xiaoyan Zeng, Hai Jiang, Shijun Li   +8 more
doaj   +1 more source

CRISPR-prime editing, a versatile genetic tool to create specific mutations with a single nucleotide resolution in Leptospira

mBio
Leptospirosis, caused by pathogenic bacteria from the genus Leptospira, is a global zoonosis responsible for more than one million human cases and 60,000 deaths annually. The disease also affects many domestic animal species.
Luis Guilherme Virgilio Fernandes, Camila Hamond, Bienvenido W. Tibbs-Cortes, Ellie J. Putz, Steven C. Olsen, Mitchell V. Palmer, Jarlath E. Nally   +6 more
doaj   +1 more source

Pentaplex real‐time PCR for differential detection of Yersinia pestis and Y. pseudotuberculosis and application for testing fleas collected during plague epizootics

MicrobiologyOpen, 2020
Upon acquiring two unique plasmids (pMT1 and pPCP1) and genome rearrangement during the evolution from Yersinia pseudotuberculosis, the plague causative agent Y. pestis is closely related to Y.
Ying Bai, Vladimir Motin, Russell E. Enscore, Lynn Osikowicz, Maria Rosales Rizzo, Andrias Hojgaard, Michael Kosoy, Rebecca J. Eisen   +7 more
doaj   +1 more source

World Health Organization Estimates of the Global and Regional Disease Burden of 22 Foodborne Bacterial, Protozoal, and Viral Diseases, 2010: A Data Synthesis

PLoS Medicine, 2015
Background Foodborne diseases are important worldwide, resulting in considerable morbidity and mortality. To our knowledge, we present the first global and regional estimates of the disease burden of the most important foodborne bacterial, protozoal, and
M. Kirk, S. Pires, R. Black, M. Caipo, J. Crump, B. Devleesschauwer, D. Döpfer, A. Fazil, Christa L. Fischer-Walker, T. Hald, A. Hall, K. Keddy, R. Lake, C. Lanata, P. Torgerson, A. Havelaar, F. Angulo   +16 more
semanticscholar   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Introduction and Application of the Interferon-γ Assay in the National Bovine Tuberculosis Control Program in South Korea

Frontiers in Veterinary Science, 2020
Bovine tuberculosis is a chronic disease impacting both public health and the livestock industry. The interferon (IFN)-γ assay has been introduced as an ancillary test for diagnosing bovine tuberculosis to overcome limitations of the skin test.
Yun-Ho Jang, Tae-woon Kim, Min Kyu Jeong, Yoon Jeong Seo, Soyoon Ryoo, Chan Ho Park, Sin seok Kang, Young Ju Lee, Soon-Seek Yoon, Jae Myung Kim   +9 more
doaj   +1 more source

Antimicrobial Resistance Profiles of Enterococcus faecium and Enterococcus faecalis Isolated from Healthy Dogs and Cats in South Korea

Microorganisms, 2023
Enterococcus spp. are typically found in the gastrointestinal tracts of humans and animals. However, they have the potential to produce opportunistic infections that can be transmitted to humans or other animals, along with acquired antibiotic resistance.
Bo-Youn Moon, Md. Sekendar Ali, Ji-Hyun Choi, Ye-Eun Heo, Yeon-Hee Lee, Hee-Seung Kang, Tae-Sun Kim, Soon-Seek Yoon, Dong-Chan Moon, Suk-Kyung Lim   +9 more
doaj   +1 more source

Diagnosis and analysis of a case of cat scratch disease combined with bacterial meningitis in a child [PDF]

, 2022
Jin Li, Yang Wen, Yanjing Wang, Yiyuan Li   +3 more
openalex   +1 more source