Results 121 to 130 of about 1,488,259 (274)

Engineered Bacterial Extracellular Vesicles: Developments, Challenges, and Opportunities

Engineering
The abundant microbe-associated molecular patterns (MAMPs) and nanoscale structures of bacterial extracellular vesicles (bEVs) collectively facilitate their versatile biological activities.
Qiqiong Li, Xinyang Chen, Junhua Xie, Shaoping Nie   +3 more
doaj   +1 more source

Sacral Neural Crest‐Derived Extracellular Vesicles Promote Pelvic Ganglion Repair Through Anti‐Pyroptotic Effects Involving ANXA1–FPR2 Signaling

Advanced Science, EarlyView.
Extracellular vesicles derived from human pluripotent stem cell‐derived sacral neural crest cells promote repair of injured major pelvic ganglia and improve colorectal function. These vesicles reduce oxidative stress and pyroptosis, with ANXA1–FPR2 signaling contributing to their protective effects, and show a favorable therapeutic profile compared ...
Ting Yang, Wenwei Liu, Hufei Wang, Yuxin Wu, Yuanchen Ma, Xiaofeng Wang, Tianxiang Lei, Qiao Tang, Yebohao Zhou, Weiqiang Li, Andy Peng Xiang, Wu Song   +11 more
wiley   +1 more source

Magnetic Resonance Reveals Radical Stability in Native Biofilms and Its Role in Bacterial Resistance

Angewandte Chemie, EarlyView.
The complex biofilm environment consists of planktonic bacterial cells and cells embedded in an extracellular matrix (ECM). Through an integrated magnetic resonance approach, we show that nitroxide radicals primarily interact with the polysaccharides and lipids in the ECM.
Alysia Mandato, Hannah Hunter, Sadhana Srinivasa, Chang‐Hyeock Byeon, Abdulkadir Tunc, Meghan K. Wells, Faith J. Scott, Frederic Mentink‐Vigier, Wook Kim, Sunil Saxena, Ümit Akbey   +10 more
wiley   +2 more sources

Microglial Extracellular Vesicles Mediate C1q Deposition at the Pre-Synapse and Promote Synaptic Pruning

C1q is released by microglia, localizes on weak synapses and acts as a tag for microglial synaptic pruning. However, how C1q tags synapses during the pruning period remains to be fully elucidated.
Barone, Cristiana, Verderio C., Saraceno C., Battocchio, Elisabetta, Colombo S. F., Gabrielli, Martina, Paolicelli, Rosa Chiara, Battocchio E., Azzoni E., Saraceno, Claudia, D'Arrigo G., Azzoni, Emanuele, Cutugno G., Barone C., Golia M. T., Gabrielli M., D'Arrigo, Giulia, Sironi F., Bellini S., Cutugno, Giulia, Frigerio, Roberto, Gagni P., Bendotti, Caterina, Sironi, Francesca, Gagni, Paola, Paolicelli R. C., Cretich, Marina, Lombardi, Marta, Ghidoni R., Ghidoni, Roberta, Colombo, Sara Francesca, Bellini, Sonia, Golia, Maria Teresa, Lombardi M., Cretich M., Verderio, Claudia, Bendotti C., Frigerio R.   +37 more
core   +1 more source

Chrysanthemum Morifolium–Derived Nanovesicles Reduce Lactate‐Associated Histone Lactylation and Modulate Microglia‐Mediated Neuroinflammation in Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
When used to treat sepsis‐associated encephalopathy, Chrysanthemum morifolium–derived nanovesicles can inhibit the H3K18la/NF‐κB axis to regulate microglia‐mediated neuroinflammation. ABSTRACT Sepsis‐associated encephalopathy (SAE)—a complication of the central nervous system in patients with sepsis—markedly diminishes cognitive functions and is linked
Kaiqiang Li, Xuling Luo, Xiaoting Zhang, Chengwen He, Wei Xu, Aibo Xu, Shushan Hua, Liping Wang, Liang Ma, Ke Hao, Youmin Ying, Zhen Wang   +11 more
wiley   +1 more source

Beyond basic characterization and omics : Immunomodulatory roles of platelet-derived extracellular vesicles unveiled by functional testing

Renowned for their role in haemostasis and thrombosis, platelets are also increasingly recognized for their contribution in innate immunity, immunothrombosis and inflammatory diseases.
Oxvig, Claus,, Kari, Otto K., Kari, Otto, Masood Kamali‐Moghaddam, Federico, Antonio,, Siljander, Pia R.M., Rikke Halse Østergaard, Kamali-Moghaddam, Masood,, Laitinen, Saara, Eble, Johannes A., Kjaer-Sorensen, Kasper, Hayashi, Yuya, Kasper Kjaer‐Sorensen, Joseph Ndika, Palviainen, Mari, Greco, Dario,, Juan M. Falcon‐Perez, Mari Palviainen, Laitinen, Saara,, Saara Laitinen, Palviainen, Mari,, Claus Oxvig, Aransay, Ana M.,, Federico, Antonio, Maaninka, Katariina, Ana M. Aransay, Falcon-Perez, Juan M., Katariina Maaninka, Pia R.‐M. Siljander, Kamali-Moghaddam, Masood, Aransay, Ana M., Eble, Johannes A.,, Halse Østergaard, Rikke,, Falcon-Perez, Juan M.,, Eble, Johannes, Butt, Umar, Butt, Umar,, Østergaard, Rikke Halse, Greco, Dario, Umar Butt, Oxvig, Claus, Ndika, Joseph,, Kjaer-Sorensen, Kasper,, Johannes A. Eble, Dario Greco, Ndika, Joseph, Johanna Puutio, Puutio, Johanna, Puutio, Johanna,, Ostergaard, Rikke, Yuya Hayashi, Kari, Otto K.,, Otto K. Kari, Antonio Federico, Siljander, Pia, Aransay, Ana, Hayashi, Yuya,, Maaninka, Katariina,, Halse Østergaard, Rikke, Siljander, Pia R. -M., Siljander, Pia R. -M.,   +60 more
core   +1 more source

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming

Advanced Science, EarlyView.
Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva, Virginia Marcia Concato‐Lopes, Fatima Bedier, Lauren Newman, Diana Kitka, Jamelle Brown, Blandine Victor, Minhyung Kim, Tatyana Vagner, Catherine Grasso, Dmitriy Sheyn, Sungyong You, Michael R. Freeman, Fayyaz S. Sutterwala, Helen S. Goodridge, Caroline Jefferies, Paola de Candia, Jlenia Guarnerio, Dolores Di Vizio   +18 more
wiley   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source