Results 101 to 110 of about 58,638 (262)

Standardizing Bacterial Extracellular Vesicle Purification: A Call for Consensus

Journal of Microbiology and Biotechnology
Bacteria constitutively produce extracellular vesicles (EVs), which play a pivotal role in linking bacterial physiology to therapeutics. Despite significant advances over the past decade, critical challenges persist in isolating EVs due to the absence of standardized purification methods.
Choi, Dongsic, Lee, Eun-Young
openaire   +2 more sources

Extraction and Analysis of RNA Isolated from Pure Bacteria-Derived Outer Membrane Vesicles [PDF]

, 2018
peer reviewedOuter membrane vesicles (OMVs) are released by commensal as well as pathogenic Gram-negative bacteria. These vesicles contain numerous bacterial components, such as proteins, peptidoglycans, lipopolysaccharides, DNA, and RNA.
LS Celbiologie-Algemeen, Patrick May, HABIER, Janine, MAY, Patrick, Ghosal, Anubrata, Anna Heintz-Buschart, Esther N. M. Nolte-‘t Hoen, WIENECKE-BALDACCHINO, Anke, Nolte-'t Hoen, Esther N M, dB&C I&I, WILMES, Paul, Wienecke-Baldacchino, Anke K, Arluison, Véronique, Paul Wilmes, FRITZ, Joëlle, Heintz-Buschart, Anna, Fritz, Joëlle V, Valverde, Claudio, Anubrata Ghosal, Anke K. Wienecke-Baldacchino, Nolte-'t Hoen, Esther N.M, Joëlle V. Fritz, Janine Habier   +22 more
core   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Recent updates on the role of extracellular vesicles in the pathogenesis of allergic asthma

, 2021
Asthma is a chronic inflammatory disease of the airway diagnosed with different endotypes and phenotypes, characterized by airway obstruction in response to allergens, bacterial/viral infections, or pollutants.
Srinivasan, Ashokkumar, Sundar, Isaac Kirubakaran   +1 more
core  

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Cutibacterium acnes–Derived Extracellular Vesicles Promote Epithelial Ovarian Cancer Progression by Activating the KEAP1–NRF2 Antioxidant Pathway to Suppress Ferroptosis

Microbial Biotechnology
Bacterial extracellular vesicles are increasingly recognized as important mediators of microbe–host communication, yet their functional roles within tumour‐associated microbiota remain poorly understood.
Qifa Huang, Qi Chen, Wenjie Xiong, Yuexi Sun, Yuxiong Huang, Ang Dai, Jianying Chen, Xue Wu, Ying Jiang, Fen Wei, Qi Chen, Tingtao Chen   +11 more
doaj   +1 more source

Rumen–mammary gland axis and bacterial extracellular vesicles: Exploring a new perspective on heat stress in dairy cows

Animal Nutrition
Heat stress poses a significant threat to the global livestock industry, particularly impacting dairy cows due to their higher metabolic heat production and increased susceptibility.
Qi Huang, Yang Xiao, Peng Sun
doaj   +1 more source

Opportunities and challenges of bacterial extracellular vesicles in regenerative medicine. [PDF]

J Nanobiotechnology
Extracellular vesicles (EVs) are membrane-bound vesicles that are shed or secreted from the cell membrane and enveloped by a lipid bilayer. They possess stability, low immunogenicity, and non-cytotoxicity, exhibiting extensive prospects in regenerative medicine (RM).
Guo J, Huang Z, Wang Q, Wang M, Ming Y, Chen W, Huang Y, Tang Z, Huang M, Liu H, Jia B.   +10 more
europepmc   +4 more sources

Staphylococcus aureus Extracellular Vesicles Carry Biologically Active beta-Lactamase

, 2018
Gram-positive bacteria naturally produce extracellular vesicles. However, little is known regarding the functions of Gram-positive bacterial extracellular vesicles, especially in the bacterial community.
Kim, YK, Lee, EY, Roh, TY, Lee, J, Kim, SH, Kim, KP, Park, KS, Kim, DK, Gho, YS   +8 more
core   +1 more source

Isolation of bacterial vesicles and characterisation of their genetic cargo

, 2020
Extracellular vesicles are small round bodies secreted from the membranes of most living cells, including bacteria. The bacterial vesicles contain many of the same components as the mother bacteria and play numerous roles in host–pathogen relationships ...
Langlete, Petter
core   +1 more source