Results 81 to 90 of about 58,638 (262)

The mFakB4 strain secretes extracellular vesicles.

, 2023
A, C) TEM images of bacterial sections, left WT, right mFakB4; A) 4000X, C) 15000X, inset 30000X (scale = 200 nm; inset scale = 100 nm); B, D) Image analysis, B) bacterial diameter length, N = 4, 24 independent images, D) percentage of vesicles per ...
Jean-Marc Masse (15368369), Karine Gloux (240654), Claire Poyart (186930), Alain Schmitt (335144), Thifaine Poullion (15368366), Agnès Fouet (197795), Clara Lambert (15368363), Qiufen Zhang (2578927)   +7 more
core   +1 more source

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, EarlyView.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

Extracellular vesicles enhance the efficacy of ceftiofur against intracellular bacterial infections

Synthetic and Systems Biotechnology
Bacterial infections pose a major threat to human health and economic stability. In particular, intracellular bacterial infections present significant clinical challenges due to antibiotic resistance and poor drug penetration.
Pingping Yuan, Shijie Zhou, Qianqian Li, Lin Li, Shaoqi Qu   +4 more
doaj   +1 more source

Bacterial extracellular vesicles exploit filopodial surfing and retraction mechanisms to reach the host cell body in an actin-dependent manner

Extracellular vesicles derived from gram-negative bacteria are nano-sized particles of different size and origin released by these microbes and are collectively called bacterial extracellular vesicles (BEVs).
Ur Rehman, Zia, Backert, Steffen, Arnqvist, Anna, Tegtmeyer, Nicole, Obi, Ikenna, Nadeem, Aftab   +5 more
core   +1 more source

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, EarlyView.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source

Gram-Positive Bacterial Extracellular Vesicles and Their Impact on Health and Disease [PDF]

Frontiers in Microbiology, 2018
During recent years it has become increasingly clear that the release of extracellular vesicles (EVs) is a feature inherent to all cellular life forms. These lipid bilayer-enclosed particles are secreted by members of all domains of life: Eukarya, Bacteria and Archaea, being similar in size, general composition, and potency as a functional entity ...
Liu, Yue, Defourny, Kyra A.Y., Smid, Eddy J., Abee, Tjakko   +3 more
openaire   +3 more sources

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Toward a better understanding of the ecological roles of extracellular vesicles from plant-associated bacteria

Applied and Environmental Microbiology
Extracellular vesicles (EVs) from phytobacteria are emerging key ecological actors of plant–bacteria interactions. They can promote colonization of the host by delivering virulence factors and cell wall-degrading enzymes.
Timothée Zannis-Peyrot, Fanny Nazaret, Céline Lavire, Ludovic Vial   +3 more
doaj   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source