Results 141 to 150 of about 57,489 (234)

Oral-Gut Microbial Crosstalk and Therapeutic Applications of Bacterial Extracellular Vesicles. [PDF]

Biomolecules
Fu W, Yang N, Yan J, Han B, Niu Q, Li Z, Bai R, Yu T.   +7 more
europepmc   +1 more source

Engineering Extracellular Vesicles: Strategies for Functional Modification and Clinical Translation

iNew Medicine, EarlyView.
The engineering modification strategies of extracellular vesicles (EVs). This figure presents the four core technical systems for the engineering modification of EVs, including direct modification strategies (physical and chemical methods), biological engineering methods, and hybrid and bionic strategies.
Zhouming Cheng, Wenhui Zhao, Min Wang, Xianwen Wang   +3 more
wiley   +1 more source

Host Factor Induced Bacterial Extracellular Vesicles Promote Horizontal Gene Transfer in Vibrio cholerae. [PDF]

J Extracell Vesicles
Fleischhacker D, Chen YC, Gordo NS, Cosic A, Kalwong R, Eberl L, Schild S.   +6 more
europepmc   +1 more source

Macrophage extracellular vesicles deliver Mef2d proteins to aggravate Bacteroides fragilis pathogenicity in type 2 diabetes arterial calcification

Interdisciplinary Medicine, EarlyView.
Bacteroides fragilis is associated with type 2 diabetes (T2D) arterial calcification and can be activated by macrophage‐derived extracellular vesicles (EVs). BF takes up EVs via receptor‐mediated endocytosis, and activation is induced by EV‐derived Mef2d, thereby inhibiting ArsR family transcriptional regulator transcription.
Cong Chen, Rong He, Jirong Luo, Zhengfeng Liang, Qunwen Pan, Shuangquan Liu, Jingsong Cao   +6 more
wiley   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

The gut-liver/bile axis: Gut microbiota and bacterial extracellular vesicles remodeling hepatobiliary pathogenesis. [PDF]

iScience
Hu S, He C, Sun K, Zhou H, Liu X, Wang H, Li S, Yu H, Xu K, Li W.   +9 more
europepmc   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Bacterial Extracellular Vesicles (BEVs) Derived from Chryseobacterium Inhibit Dengue Virus Infection by Disrupting Its Structural Integrity. [PDF]

J Extracell Vesicles
Gao Y, Zhang L, Zhang T, Yao Q, Gao R, Wang Y, Zhao Y, Zhou T, Chen J, Zhang X, Ren H, Zhu Y, Zhao P, Qi Z, Luo L, Qin Z.   +15 more
europepmc   +1 more source

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

Bacterial extracellular vesicles from Streptococcus mutans drive OSCC progression through β-catenin signaling. [PDF]

Sci Rep
Cao G, Jiang Y, Li X, Liu R, Liu K, Balcha F, Ding M, Yuan M, Li T, Fang Y.   +9 more
europepmc   +1 more source