Results 181 to 190 of about 55,076 (228)

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Engineered bacterial extracellular vesicles mediate pyroptosis to counteract m⁶A methylation-based immunosuppression after insufficient radiofrequency ablation of hepatocellular carcinoma. [PDF]

Acta Pharm Sin B
Xiao Z, Yuan J, Wu Q, Qin J, Liu Y, Zhang S, Sun B, Dai R, Zhang P, Shao N, Che S, He Y, Chen J, Wen S, Hu K, Wang D, Luo L.   +16 more
europepmc   +1 more source

Stimuli‐responsive hydrogels: An intelligent tool for wound management

Interdisciplinary Medicine, EarlyView.
For chronic and complex wounds, this review focuses on intelligent hydrogels capable of responding to wound microenvironmental cues (e.g., pH, enzymes) or external stimuli (e.g., light, electricity). These advanced materials enable the dynamic regulation of drug release and real‐time monitoring of healing progression, thereby offering innovative ...
Debin Zheng, Meiqi Zhu, Xi Liu, Cuiping Zhang, Di Wu, Tianyu Xie, Chen Li, Pei Zhao, Wenting Chen, Xiaobing Fu, Xiaoxue Li   +10 more
wiley   +1 more source

Identification of Released Bacterial Extracellular Vesicles Containing Lpp20 from <i>Helicobacter pylori</i>. [PDF]

Microorganisms
Okamoto A, Shibuta T, Morita N, Fujinuma R, Shiraishi M, Matsuda R, Okada M, Watanabe S, Umemura T, Takeuchi H.   +9 more
europepmc   +1 more source

Intratumoral bacteria engineered for tumor therapy

Interdisciplinary Medicine, EarlyView.
This article comprehensively reviews engineered intratumoral bacteria used in tumor therapy. The concept development, characteristics, and engineering methods of intratumoral bacteria are summarized. The mechanisms and the translational significance by which engineered intratumoral bacteria interfere with tumor progression are discussed and highlighted.
Huajie Zhang, Zelin Chen, Zeyu Yao, Sishi Luo, Cheng Luo, Rui Yang, Hao Fu, Songyin Huang   +7 more
wiley   +1 more source

Bacterial extracellular vesicles target different bacterial species, impairing cell division and diminishing their pathogenicity. [PDF]

Proc Natl Acad Sci U S A
Kawagishi Y, Murase K, Grebenshchikova A, Iibushi J, Ma C, Kimeu TM, Minowa-Nozawa A, Nozawa T, Nakagawa I.   +8 more
europepmc   +1 more source

Recent progress on stimuli‐responsive chitosan‐based biomaterials as drug carriers

Interdisciplinary Medicine, EarlyView.
This review discusses the recent progress in chitosan‐based drug delivery systems that respond to pH, redox, enzymes, reactive oxygen species, and combined stimuli. It examines design strategies, key mechanisms, and therapeutic applications, and also addresses current challenges while suggesting future approaches to enhance clinical translation and ...
Changlu Xu, Yi‐Tung Lu, Bin Yang, Zhi Li, Kui Zeng   +4 more
wiley   +1 more source

Unveiling a Novel Mechanism of Enhanced Secretion, Cargo Loading, and Accelerated Dynamics of Bacterial Extracellular Vesicles Following Antibiotic Exposure. [PDF]

J Extracell Vesicles
Li J, Li C, Han Y, Hu Y, Yang J, Xu H, Chen X, Yang M, Zuo J, Tang Y, Lei C, Li C, Wang H.   +12 more
europepmc   +1 more source

Effects of Mesenchymal Stem Cell‐Derived Exosomes on Lung Inflammation in a Murine Aspiration Model

The Laryngoscope, EarlyView.
This study assessed the effect of intravenous MSC‐derived exosomes on inflammatory lung injury in a rat model of LPS aspiration. Compared with LPS alone, MSC exosome treatment reduced histologic lung injury overall (significant group effect p = 0.02; linear trend p = 0.006) and significantly lowered Tnf gene expression on qRT‐PCR (p < 0.05).
Nogah Nativ‐Zeltzer, Rumi Ueha, Johnathon D. Anderson, Yuval Nachalon, Denise M. Imai, Peter C. Belafsky   +5 more
wiley   +1 more source