Results 51 to 60 of about 58,638 (262)

Engineering strategies and biomedical applications of bacterial extracellular vesicles. [PDF]

Biomater Transl
Bacterial extracellular vesicles (BEVs) are emerging as promising therapeutic agents and drug delivery vehicles due to their unique properties. These nanoscale vesicles possess stable membrane structure and naturally encapsulate a variety of bioactive molecules, making them versatile tools in biomedical applications.
Liang X, Li Q, Zheng L, Situ B.
europepmc   +3 more sources

Antimicrobial surfaces based on self-assembled nanoreactors : from block copolymer synthesis to bacterial adhesion study [PDF]

, 2010
The aim of this work is to develop a new strategy for the prevention of biofilm growth. For this purpose, we prepared bioactive surfaces resulting from the surface-immobilization of nanoreactors self-assembled from amphiphilic poly(isobutylene)-block ...
Cottenye, Nicolas
core   +1 more source

Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell-type specific manner that are altered in inflammatory bowel disease [PDF]

, 2021
The gastrointestinal (GI) tract harbours a complex microbial community, which contributes to its homeostasis. A disrupted microbiome can cause GI-related diseases, including inflammatory bowel disease (IBD), therefore identifying host-microbe ...
Sonia Fonseca, Thomas, John P., Stentz, Régis, Dezso Modos, Lejla Gul, Modos, Dezso, Booth, Catherine, Simon R. Carding, Tamas Korcsmaros, Padhmanand Sudhakar, Carding, Simon R., Régis Stentz, Fonseca, Sonia, Gul, Lejla, Thomas, John P, Korcsmaros, Tamas, Matthew Madgwick, Sudhakar, Padhmanand, Carding, Simon R, John P. Thomas, Madgwick, Matthew, Catherine Booth   +21 more
core   +1 more source

Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes

mBio, 2023
Extracellular vesicles are considered to be an inflammatory factor in several acute and chronic inflammatory diseases. The present study shows that exosomes from macrophages (Mφ) infected with live Escherichia coli induced secretion of proinflammatory ...
Risa Imamiya, Akari Shinohara, Daisuke Yakura, Takehiro Yamaguchi, Koji Ueda, Ami Oguro, Yukiko Minamiyama, Hiroshi Ichikawa, Yasuhiko Horiguchi, Mayuko Osada-Oka   +9 more
doaj   +1 more source

Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2‐dependent fashion

, 2023
Filaggrin (FLG) protein is indispensable for multiple aspects of the epidermal barrier function but its accumulation in a monomeric filaggrin form may initiate premature keratinocytes death; it is unclear how filaggrin levels are controlled before the ...
Kinga Panek, Paul, Argho Aninda, Gabrielsson, Susanne, Gutowska-Owsiak, Danuta, Panek, Kinga, Lilit Hovhannisyan, Królicka, Aleksandra, Ewa Czechowska, Adrian Kobiela, Rychłowski, Michał, Pikuła, Michał, Aleksandra Bogucka, Aleksandra Królicka, Jacek Zieliński, Hovhannisyan, Lilit, Michał Pikuła, Magdalena Trzeciak, Czechowska, Ewa, Argho Aninda Paul, Susanne Gabrielsson, Zieliński, Jacek, Deptuła, Milena, Jorge Bernardino dela Serna, Michał Rychłowski, Danuta Gutowska‐Owsiak, Jurkowska, Paulina, Trzeciak, Magdalena, de la Serna, Jorge Bernardino, Jorge Bernardino de la Serna, Paulina Jurkowska, Kobiela, Adrian, Graham S Ogg, Milena Deptuła, Ogg, Graham S, Bogucka, Aleksandra   +34 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Adaptations of Bacterial Extracellular Vesicles in Response to Antibiotic Pressure. [PDF]

Int J Mol Sci
Extracellular vesicles (EVs) are nanometer-sized lipid structures actively secreted by Gram-negative and Gram-positive bacteria, representing a sophisticated microbial adaptation and communication strategy. These structures are involved in biomolecular transport, the regulation of biological processes, the modulation of host–pathogen interactions, and ...
Federica D, Cosimato I, Salzano F, Mensitieri F, Andretta V, Santoro E, Boccia G, Folliero V, Franci G.   +8 more
europepmc   +4 more sources

extracellular vesicle proteome identifies markers of purity and culture conditions

, 2019
Bacteria release nano-sized extracellular vesicles (EVs) into the extracellular milieu. Bacterial EVs contain molecular cargo originating from the parent bacterium and have important roles in bacterial survival and pathogenesis.
Blenkiron, Cherie, Whitcombe, Alana, Priscila Dauros‐Singorenko, Alana Whitcombe, Swift, Simon, Jiwon Hong, Anthony Phillips, Payne, Leo, Dauros Singorenko, Priscila, Simon Swift, Phillips, Anthony, Cherie Blenkiron, Leo Payne, Hong, Jiwon   +13 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Emerging Roles of Extracellular Vesicles in Pneumococcal Infections: Immunomodulators to Potential Novel Vaccine Candidates

Frontiers in Cellular and Infection Microbiology, 2022
The Gram-positive bacterial pathogen, Streptococcus pneumoniae is a major global health threat that kills over one million people worldwide. The pneumococcus commonly colonizes the nasopharynx asymptomatically as a commensal, but is also capable of ...
Saba Parveen, Karthik Subramanian
doaj   +1 more source