Results 21 to 30 of about 920,931 (266)

Clinico-epidemiological determinants for empirical antibiotic prescriptions in suspected urinary tract infection cases attending peripheral hospitals of West Bengal, India- a cross sectional analysis

Scientific Reports
Primary and Secondary care hospitals in India do not have any microbiological diagnostic facilities, hence clinicians in these hospitals primarily depend on clinical and epidemiological features of patients for their empiric antibiotic treatment decision.
Debjit Chakraborty, Pradeep Kumar Panda, Falguni Debnath, Rajyasree Ghosh De, Agniva Majumdar, Saibal Das, Sanjuckta Pramanick, Deotima Sarkar, Arpan Bhadra, Tamal Ghorai, Sulagna Basu, Atreyi Chakrabarti, Arup Chakraborty, Dipankar Maji, Alok Kumar Deb, Pinaki Panigrahi, Santasabuj Das, Sanghamitra Pati   +17 more
doaj   +1 more source

Genomic epidemiology of Shigella in the United Kingdom shows transmission of pathogen sublineages and determinants of antimicrobial resistance

Scientific Reports, 2018
Shigella are globally important diarrhoeal pathogens that are endemic in low-to-middle income nations and also occur in high income nations, typically in travellers or community-based risk-groups. Shigella phylogenetics reveals population structures that
Kate S. Baker, Timothy J. Dallman, Nigel Field, Tristan Childs, Holly Mitchell, Martin Day, François-Xavier Weill, Sophie Lefèvre, Mathieu Tourdjman, Gwenda Hughes, Claire Jenkins, Nicholas Thomson   +11 more
doaj   +1 more source

Staphylococcus aureus Multiplexes Death-Effector Deoxyribonucleosides to Neutralize Phagocytes

Frontiers in Immunology, 2022
Adenosine synthase A (AdsA) is a key virulence factor of Staphylococcus aureus, a dangerous microbe that causes fatal diseases in humans. Together with staphylococcal nuclease, AdsA generates deoxyadenosine (dAdo) from neutrophil extracellular DNA traps ...
Eshraq Tantawy, Eshraq Tantawy, Nicoletta Schwermann, Nicoletta Schwermann, Tjorven Ostermeier, Tjorven Ostermeier, Annette Garbe, Heike Bähre, Marius Vital, Volker Winstel, Volker Winstel   +10 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species

Nature Communications, 2018
Antimicrobial resistance (AMR) in Shigella species is a public health concern. Here, Baker et al. show how horizontal transfer of an AMR plasmid among Shigella species contributes to epidemics in men who have sex with men in England.
Kate S. Baker, Timothy J. Dallman, Nigel Field, Tristan Childs, Holly Mitchell, Martin Day, François-Xavier Weill, Sophie Lefèvre, Mathieu Tourdjman, Gwenda Hughes, Claire Jenkins, Nicholas Thomson   +11 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Septins and Bacterial Infection [PDF]

Frontiers in Cell and Developmental Biology, 2016
Septins, a unique cytoskeletal component associated with cellular membranes, are increasingly recognized as having important roles in host defense against bacterial infection. A role for septins during invasion of Listeria monocytogenes into host cells was first proposed in 2002.
Torraca, V, Mostowy, S
openaire   +4 more sources

Serological evidence of Francisella tularensis in febrile patients seeking treatment at remote hospitals, northeastern Kenya, 2014–2015

New Microbes and New Infections, 2017
Tularaemia is a highly contagious infectious zoonosis caused by the bacterial agent Francisella tularensis. The aim of this study was to investigate the presence of antibodies to F. tularensis in febrile patients in northeastern Kenya.
J. Njeru, H. Tomaso, K. Mertens, K. Henning, G. Wareth, R. Heller, S. Kariuki, E.M. Fèvre, H. Neubauer, M.W. Pletz   +9 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Prediction of potential NS3-based T cell epitopes of hepatitis C virus by in-silico and in-vitro approach

Scientific Reports
Due to the absence of an effective vaccine and suboptimal responses to direct-acting antivirals (DAA), Hepatitis C virus (HCV) genotype 3—prevalent in South Asia, the Middle East, and Central Asia—remains a significant public health challenge. This study
Supradip Dutta, Amlanjyoti Dhar, Meghamala Pande, Ankita Ghose, Moumita Majumdar, Sagnik Bakshi, Raina Das, Shreyasi Nath, Anwesha Ghosh, Provash Chandra Sadhukhan   +9 more
doaj   +1 more source