Results 41 to 50 of about 920,931 (266)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Science and prizes

EMBO Reports
Scientific prizes award those making important discoveries, define a field, further the public understanding of science, or support young and upcoming researchers. But they should also encourage scientists to take risks and venture into the unknown.
Vic Norris
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A Case Report of Gilbert Syndrome Presenting With Acute Cholecystitis

Clinical Case Reports
A 38‐year‐old male with Gilbert syndrome presented with acute cholecystitis, jaundice, and elevated liver enzymes. This case highlights the importance of genetic testing for unexplained jaundice, avoiding misdiagnosis, and guiding personalized treatment ...
Shu‐Qi Yang, Yi‐Jie Lin, Hua‐Tang Zhang, Xing Wang, Yan‐Yan Qiu, Yan‐Yan Lin, Xue‐Ping Yu   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Clinical Characteristics and Prognosis of AIDS Complicated with Talaromycosis marneffei Infection: a Single-Center Retrospective Study

Infectious Diseases and Therapy
Introduction The objective of the study was to determine the clinical features and prognostic risk factors of acquired immunodeficiency syndrome (AIDS) combined with Talaromyces marneffei (TM) infection.
Zhangyan Weng, Yijie Lin, Wenliang Dai, Yijuan Zheng, Huatang Zhang, Minghui Zheng, Haoyi He, Youzhi Hong, Dawu Zeng, Zhijun Su, Xueping Yu   +10 more
doaj   +1 more source

Asymmetric peptidoglycan editing generates cell curvature in Bdellovibrio predatory bacteria

Nature Communications, 2022
Cells of the predatory bacterium Bdellovibrio bacteriovorus, which invades and replicates within the periplasm of other bacteria, have a characteristic curved rod shape. Here, Banks et al.
Emma J. Banks, Mauricio Valdivia-Delgado, Jacob Biboy, Amber Wilson, Ian T. Cadby, Waldemar Vollmer, Carey Lambert, Andrew L. Lovering, R. Elizabeth Sockett   +8 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Efficacy of TDF, TAF, TMF, and TDF-to-TAF switch in chronic hepatitis B: a network meta-analysis

BMC Gastroenterology
Objective We compared the efficacy of four treatment strategies for chronic hepatitis B (CHB): tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF), tenofovir amibufenamide (TMF), and TDF-to-TAF switch strategies strategy.
Shuqi Yang, Yijie Lin, Huatang Zhang, Yanlan Liang, Wenjin Yuan, Xing Wang, Wenwu Lin, Wencong Hong, Zhijun Su, Dawu Zeng, Xueping Yu   +10 more
doaj   +1 more source