Results 71 to 80 of about 3,994,641 (352)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Lipoarabinomannan in sputum to detect bacterial load and treatment response in patients with pulmonary tuberculosis: Analytic validation and evaluation in two cohorts

PLoS Medicine, 2019
Background Lipoarabinomannan (LAM) is a major antigen of Mycobacterium tuberculosis (MTB). In this report, we evaluated the ability of a novel immunoassay to measure concentrations of LAM in sputum as a biomarker of bacterial load prior to and during ...
M. Kawasaki, Carmenchu Echiverri, L. Raymond, Elizabeth Cadena, Evelyn Reside, M. T. Gler, T. Oda, Ryuta Ito, Ryo Higashiyama, K. Katsuragi, Yongge Liu   +10 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Descripción de una nueva combinación de técnicas para el desbridamiento de heridas crónicas Description of a new combination of technics for the debridement of chronic wounds

Gerokomos, 2010
En el presente artículo presentamos la evolución clínica de una paciente con una lesión por presión estadio IV en el sacro. Describimos la utilización de una nueva pauta de desbridamiento mediante la combinación de un apósito de hidrofibra de ...
Antonio Erasto Villar Rojas, Álvaro Rafael Villar Hernández, María Díaz Mateos   +2 more
doaj  

Bacterial analysis of biofilms from tooth root surfaces presenting different caries activity

Revista da Faculdade de Odontologia de Porto Alegre, 2020
This study evaluated the numbers and determined the proportion of mutans streptococci and Lactobacillus spp., which are possible relevant cariogenic organisms, in biofilms recovered from lesions at root surfaces with active caries lesions (ARC), inactive
Sandra Liana Henz, Nailê Teixeira Damé, Cristiane Neves Portugal, Marisa Maltz   +3 more
doaj   +1 more source

The Effectiveness of 0.6% Povidone Iodine Eye Drops in Reducing the Conjunctival Bacterial Load and Needle Contamination in Patients Undergoing Anti-VEGF Intravitreal Injection: A Prospective, Randomized Study

Journal of Clinical Medicine, 2019
The study purpose was to assess the efficacy of a preservative-free 0.6% povidone iodine eye drops as perioperative prophylactic treatment for reducing conjunctival bacterial load and the rate of needle contamination in patients undergoing intravitreal ...
M. Reibaldi, T. Avitabile, F. Bandello, A. Longo, V. Bonfiglio, Andrea Russo, Niccolò Castellino, R. Rejdak, K. Nowomiejska, M. Toro, C. Furino, S. Cillino, T. Fiore, C. Cagini, P. Grassi, R. Musumeci, C. Cocuzza, M. Martinelli, M. Fallico   +18 more
semanticscholar   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Bacterial Load Reduction in Guheswori Sewage Treatment Plant, Kathmandu, Nepal

Journal of College of Medical Sciences-Nepal, 2019
Background: Water sources such as lakes, ponds, river etc. have been continuously contaminated by the   micro organisms and chemicals. The former can pose a significant threat to human health.
Bikram Gautam, Anjita Rajbhanshi, Rameshwar Adhikari   +2 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

New techniques for wound management: A systematic review of their role in the management of chronic wounds

Archives of Plastic Surgery, 2018
Debridement is a crucial component of wound management. Recent technologies such as hydrosurgery (Versajet), ultrasound therapy (the MIST therapy device), or plasma-mediated bipolar radio-frequency ablation therapy (Coblation) seem to represent ...
Farid Bekara, Julian Vitse, Sergiu Fluieraru, Raphael Masson, Antoine De Runz, Vera Georgescu, Guillaume Bressy, Jean Louis Labbé, Benoit Chaput, Christian Herlin   +9 more
doaj   +1 more source