Results 71 to 80 of about 2,216,688 (307)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Dentition Type as a Determinant of Microbial Load Reduction by Antimicrobial Photodynamic Therapy in Deep Dentin Caries: A Systematic Review and Meta-analysis [PDF]

Journal of Dentistry
Statement of the Problem: Antimicrobial photodynamic therapy (aPDT) is a protocol proposed for reduction of bacterial load in deep dentin caries in primary and permanent dentitions.
Zahra Baghani, Malihe Karrabi, Hossein Assarzadeh   +2 more
doaj   +1 more source

Efficacy of Preoperative and Intraoperative Skin and Nail Surgical Preparation of the Foot in Reducing Bacterial Load

, 2010
Background: A common problem associated with toenail removal surgery is the accompanying bacterial infection that often ensues. The foot has a particularly difficult anatomy to prepare antiseptically for surgery, which contributes to this wide-spread ...
DAVID SEVILLANO FERNÁNDEZ, Alou Cervera, Luis, JOSÉ PRIETO PRIETO, Becerro De Bengoa Vallejo, Ricardo, MARTA ELENA LOSA IGLESIAS, LUIS ALOU CERVERA, Losa Iglesias, Marta Elena, RICARDO BECERRO DE BENGOA VALLEJO, Prieto Prieto, José, Sevillano Fernández, David   +9 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Changes in Mycobacterium tuberculosis-Specific Immunity With Influenza co-infection at Time of TB Diagnosis

Frontiers in Immunology, 2019
Background: Prior Influenza A viral (IAV) infection has been shown to increase susceptibility to tuberculosis (TB) and TB has also been shown to be a primary cause of death during pandemics, including the Spanish Influenza outbreak of 1918–1919.
Joseph Mendy, Sheikh Jarju, Rhiannon Heslop, Rhiannon Heslop, Adama L. Bojang, Beate Kampmann, Jayne S. Sutherland   +6 more
doaj   +1 more source

The effect of disinfectant ingredients on teat skin bacteria associated with mastitis in Irish dairy herds

Irish Veterinary Journal, 2021
Background Teat disinfection is an important step in the control of mastitis within a dairy herd. The objective of this study was to evaluate the effectiveness of 96 commercially available teat disinfectant products in Ireland against bacterial isolates ...
Sarah Rose Fitzpatrick, Mary Garvey, Jim Flynn, Bernadette O’Brien, David Gleeson   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

PCR profiling of tumor-associated microorganisms in tissue of primary epithelial malignant tumors of colorectal origin: associations with key clinicopathological characteristics

Frontiers in Cellular and Infection Microbiology
IntroductionColorectal cancer is one of the most common malignancies worldwide, and microbiome research has strong potential to advance understanding of tumor biology and to support biomarker development and microbiome-targeted interventions.
Nikolay K. Shakhpazyan, Liudmila M. Mikhaleva, Nikolay K. Sadykhov, Konstantin Y. Midiber, Konstantin Y. Midiber, Roman V. Afanasev, Zarina V. Gioeva, Alexander I. Mikhalev, Arkady L. Bedzhanyan   +8 more
doaj   +1 more source

Autonomous Generation and Loading of DNA Guides by Bacterial Argonaute [PDF]

Molecular Cell, 2017
Several prokaryotic Argonaute proteins (pAgos) utilize small DNA guides to mediate host defense by targeting invading DNA complementary to the DNA guide. It is unknown how these DNA guides are being generated and loaded onto pAgo. Here, we demonstrate that guide-free Argonaute from Thermus thermophilus (TtAgo) can degrade double-stranded DNA (dsDNA ...
Swarts, Daan C., Szczepaniak, Malwina, Sheng, Gang, Chandradoss, Stanley D., Zhu, Yifan, Timmers, Elizabeth M., Zhang, Yong, Zhao, Hongtu, Lou, Jizhong, Wang, Yanli, Joo, Chirlmin, van der Oost, John   +11 more
openaire   +3 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source