Results 111 to 120 of about 140,542 (270)

TGFβ receptor II gene deletion in leucocytes prevents cerebral vasculitis in bacterial meningitis [PDF]

, 2017
In bacterial meningitis, chemokines lead to recruitment of polymorphonuclear leucocytes (PMN) into the CNS. At the site of infection in the subarachnoid space, PMN release reactive oxygen species, reactive nitrogen intermediates (RNI) and interleukin-1β (
Bürki, Kurt, Fontana, Adriano, Koedel, Uwe, Levéen, Per, Malipiero, Ursula, Pfister, Hans-Walter, Reith, Walter   +6 more
core  

Impact of the BioFire FilmArray Meningitis‐Encephalitis Panel on Management of Suspected Paediatric Central Nervous System Infections: A Single‐Centre Retrospective Cohort Study

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Background Meningoencephalitis causes significant morbidity and mortality in children worldwide. Prompt diagnosis remains challenging, yet advances in molecular diagnostic technology have improved diagnostic performance. This study examined whether the introduction of the BioFire FilmArray meningitis/encephalitis (ME) multiplex panel impacted ...
Louisa Mary Churcher, Adam William Bartlett, Stella Pendle, Rob Slade, Phoebe C. M. Williams   +4 more
wiley   +1 more source

Incorporating the Competencies of Evidence‐Based Veterinary Medicine Focused on Pharmacotherapeutics Into Clinical Rotations for Small Animal Dermatology and Food Animal Medicine and Surgery at a Veterinary Medical Teaching Hospital in the US

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Building the skills and knowledge necessary to practice evidence‐based veterinary medicine (EBVM) should occur throughout the veterinary curriculum. Operationalizing EBVM includes asking a clinical question in PICO format, searching the biomedical literature for evidence, critically appraising the evidence, and applying the evidence to make a ...
Virginia R. Fajt, Adam P. Patterson, Dusty Nagy, Jennifer Schleining, Kevin Washburn   +4 more
wiley   +1 more source

Steroid Therapy for Bacterial Meningitis [PDF]

, 2017
Routine dexamethasone therapy for bacterial meningitis in pediatric patients is controversial. Two experts debated this topic at the 1993 meeting of the Infectious Diseases Society of America.
Kaplan, Sheldon L., McCracken, George H., Schaad, Urs B.   +2 more
core  

Pharmacokinetics of Long‐Acting Ampicillin and Its Impact on the Gut Microbiome and Resistome in Rhesus Macaques (Macaca mulatta)

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Injectable antimicrobials with documented prolonged dosing intervals (> 48 h) for use in rhesus macaques are sparse. The objective of our study was to assess the pharmacokinetics, urine excretion, and effects on gut microbiome and resistome of intramuscular administered long‐acting formulation of ampicillin (Albipen LA) in macaques.
Annemiek Maaskant, Ingeborg M. van Geijlswijk, Mathias Devreese, Marc Cherlet, Leo F. van Geest, Jaap A. Wagenaar, Jan A. M. Langermans, Aldert L. Zomer, Jaco Bakker, Ronette Gehring   +9 more
wiley   +1 more source

Tumor necrosis factor-alpha and interleukin-1 beta levels in children with bacterial, tuberculous and aseptic meningitis

The Turkish Journal of Pediatrics, 1997
Cerebrospinal fluid levels of tumor necrosis factor-alpha and interleukin-1 beta in 78 children with nonbacterial, bacterial and tuberculous meningitis, and in 34 control subjects were analyzed in order to evaluate the involvement of these ...
M Ceyhan, G Kanra, Z Ecevit, G Seçmeer, G Erdem, O Akan, O Müftüoğlu   +6 more
doaj  

Estimation of serum and CSF lactate as a diagnostic and prognostic marker of bacterial and aseptic meningitis in adults: experience from a tertiary care center

MGM Journal of Medical Sciences
Background: Data on the utility of cerebrospinal fluid (CSF) lactate and serum lactate as prognostic markers for bacterial and viral meningitis remain scarce in the Indian setting.
Hasim Reza, Soumyasil Das, Debasish Gond, Linkon Biswas, Subrata Kumar Pal   +4 more
doaj   +1 more source

Photodynamic inactivation increases cell death rate on persistent Staphylococcus aureus

Photochemistry and Photobiology, EarlyView.
Persistent bacteria have the ability to survive extended periods of antibiotic stress by entering a metabolically dormant state. This study investigated persistence formation in two S. aureus strains and evaluated the effects of PDI using curcumin. Post‐PDI time‐kill assays conducted after metabolic recovery showed a higher rate of bacterial death ...
Maria Vitória Silva Pereira, Bruna Carolina Corrêa, Vanderlei Salvador Bagnato, Kate Cristina Blanco   +3 more
wiley   +1 more source

Immunomodulatory effects of cathelicidin in the gut–brain axis: A novel link between mucosal immunity and neuroinflammation

Experimental Physiology, EarlyView.
Abstract Cathelicidins are evolutionarily conserved host defence peptides known for their dual antimicrobial and immunomodulatory functions. Among them, LL‐37 in humans and CRAMP in rodents have emerged as crucial regulators of both mucosal immunity and CNS inflammation.
Mehrdad Nourizadeh, Amir Arsalan Ghahari, Ehsan Zandi, Seyedeh Zeynab Rasouli, Shaghayegh Davari, Mobina Hoseinzadeh, Mir Alireza Nourazar   +6 more
wiley   +1 more source

Zoonotic risks in urban areas: Prevalence of helminth parasites in urban populations of Lissachatina fulica in Sarawak, Malaysia

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background The giant African land snail (Lissachatina fulica), an invasive species with significant medical, agricultural and economic importance, is abundant in urban areas of Kota Samarahan, Sarawak. The proximity between humans and the snail may increase the risk of pathogen transmission.
Farid Farhan Mohd Nor, Nur Aniyah Sulaiman, Tiffany Junior Singgah Iddie, Dayang Norafizan Awang Chee, Madinah Adrus   +4 more
wiley   +1 more source