Results 131 to 140 of about 1,029,387 (219)
The Role of Astrocytes in the Inflammatory Response in Neurodiseases
Reactive astrocyte‐mediated pathogenic mechanisms in neurodegenerative diseases Schematic representation of key astrocytic pathways contributing to pathology in the pathogenesis of AD, PD, ALS, and HD. In AD, astrocytes exhibit Aβ plaque‐associated activation characterized by GFAP/S100β upregulation, accompanied by impaired EAAT2‐mediated glutamate ...
Shijun Peng +3 more
wiley +1 more source
Abstract A 5‐year‐old, spayed, female Shiba Inu was presented with a 6‐week history of reduced appetite, lethargy and generalised stiffness, which showed only limited improvement despite anti‐inflammatory treatment. The most significant clinical abnormalities were pyrexia, stiffness, pain on joint manipulation and cutaneous lesions. Laboratory findings
Jeanne Bergeat +6 more
wiley +1 more source
Fuzzy Expert System for Diagnosis of Bacterial Meningitis from Other Types of Meningitis in Children
Introduction: Bacterial meningitis requires timely diagnosis and treatment otherwise it will have relatively high complications and mortality and morbidity.
Mostafa Langarizade +3 more
doaj
The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley +1 more source
Estudi experimental del tractament de la meningitis pneumocòcica produïda per soques resistents a cefalosporines de tercera generació. Virulència, eficàcia i resposta inflamatòria [PDF]
[cat] La meningitis pneumocòcica és una malaltia associada a una elevada mortalitat (20-40) i a l'aparició de seqüeles neurològiques en un 30% dels pacients, nens i adults, que sobreviuen.
Ribes Miravet, Sandra
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Vaccinations During Pregnancy Protect the Mother–Infant Dyad and Are Generally Safe
ABSTRACT Aim Vaccination in pregnancy has a critical impact on mothers, foetuses and infants. The aim of this paper was to summarise key points presented by experts attending the 12th Maria Delivoria‐Papadopoulos Perinatal Symposium in March 2025 and further expand and update them.
Ariadne Malamitsi‐Puchner +2 more
wiley +1 more source
A Global Perspective of Childhood Vaccinations: Past, Present, and Future—From Smallpox to mRNA
ABSTRACT Childhood immunisation is one of the most successful public health interventions in history, preventing millions of deaths and substantially reducing global child mortality. This mini‐review summarises the historical development of childhood vaccines, the role of global coordination in expanding immunisation coverage, and the innovations that ...
Tobias Alfvén, Tania Reza, Alieu Sowe
wiley +1 more source
Trained Immunity in Childhood Vaccination
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai +2 more
wiley +1 more source
KO‐NH2 is a synthetic metallophore that preferentially binds Ga3+ over Fe3+ and is recognized by bacterial transporters. Photocrosslinking identifies CirA and Fiu as key uptake proteins in E. coli. KO‐NH2 enables targeted imaging and treatment of E. coli soft tissue infections.
Phuong Nguyen Tran +5 more
wiley +2 more sources
Clinical decision rules for acute bacterial meningitis: current insights
Alain Viallon,1 Elisabeth Botelho-Nevers,2 Fabrice Zeni3 1Emergency Department, 2Department of Infectious Disease, 3Intensive Care Unit, University Hospital, Saint-Etienne, France Abstract: Acute community-acquired bacterial meningitis (BM) requires ...
Viallon A, Zeni F, Botelho-Nevers E
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