Results 111 to 120 of about 966,194 (282)

Trained Immunity in Childhood Vaccination

Acta Paediatrica, EarlyView.
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai, Lubnaa Hossenbaccus, Eva Kaufmann   +2 more
wiley   +1 more source

Pathogenesis of bacterial meningitis.

, 1999
Bacterial meningitis is fatal in 5% to 40% of patients and causes neurologic sequelae in up to 30% of survivors. Much has been learned recently about the mechanisms that lead to brain injury during meningitis.
Leib, Stephen, Täuber, Martin G.
core   +1 more source

Clinical Conditions Associated With Elevated Lactate Levels in Hospitalized Children

Acta Paediatrica, EarlyView.
ABSTRACT Aim Lactate is included in adult septic shock criteria, but its role in paediatric sepsis is unclear. Recent guidelines propose lactate thresholds, though supporting evidence is limited. We aimed to identify conditions associated with elevated lactate in children and determine where levels are highest.
Eveliina Kuitunen, Ilari Kuitunen, Miika Arvonen, Marjo Renko   +3 more
wiley   +1 more source

The benefits of multidisciplinary collaboration in the successful management of two complex feline cases

Australian Veterinary Journal, EarlyView.
Despite a frequent misconception that behavioural concerns are diagnoses of exclusion, medical conditions and behavioural disorders are frequently inter‐related. In human medicine, the ‘multidisciplinary team’ approach (MDTA) is considered the most efficacious way of managing patients with complex and chronic health conditions.
BE Bollaert, JM Ley, HE Zulch
wiley   +1 more source

Bacterial meningitis in neonates and infants – the sonographic picture

, 2018
Bacterial meningitis is a major diagnostic and therapeutic problem among children and neonates, with severe, rapidly progressing course and potentially life-threatening complications.
Stępień-Roman, Monika, Zeno Spârchez, Błażej Littwin, Littwin, Błażej, Spârchez, Zeno, Kosiak, Wojciech, Pomiećko, Andrzej, Monika Stępień-Roman, Wojciech Kosiak, Andrzej Pomiećko   +9 more
core   +1 more source

Health Research Funders and Justice: Obligations to Coordinate and Counterbalance

Bioethics, EarlyView.
ABSTRACT Government health research funders are frequently criticized on the grounds that their distribution of resources fails to reflect a population's disease burden. These critiques do not take into account what other research funders are doing. In this paper, I argue that this is a mistake.
Joseph Millum
wiley   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Computed tomographic diagnosis and treatment of pneumolabyrinth in a mare with temporohyoid osteoarthropathy

Equine Veterinary Education, EarlyView.
Summary Pneumolabyrinth, which is the presence of gas within the labyrinth of the inner ear, can be associated with severe peripheral vestibular signs. This report describes a case of pneumolabyrinth in a horse that presented with vestibular ataxia. An 8‐year‐old Quarter Horse mare that presented with cranial nerve VII deficits underwent a standing ...
C. A. Jamieson, J. Jarvis, O. Nagasaka, M. Murakami, C. V. Fulkerson, A. C. B. C. F. Pinto   +5 more
wiley   +1 more source

Bacterial Meningitis in Childhood

, 2011
A wide variety of pathogens cause childhood meningitis and clinical features and ­outcomes vary according to the organism. Bacterial meningitis caused by Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) is of particular importance as it has a high mortality and morbidity, has been relatively common and is ...
Sadarangani, M, Pollard, A
openaire   +3 more sources

Should equine practitioners still prescribe chloramphenicol for treating horses?

Equine Veterinary Education, EarlyView.
Summary Background Clinical breakpoints for chloramphenicol are not currently available to test susceptibility of bacteria isolated from horses. Without these breakpoints, testing the susceptibility of bacterial isolates from horses cannot be interpreted properly.
M. G. Papich, L. A. Gunnett, M. N. Martinez   +2 more
wiley   +1 more source