Results 11 to 20 of about 172,115 (282)

Biomimetic Lipopolysaccharide‐Free Bacterial Outer Membrane‐Functionalized Nanoparticles for Brain‐Targeted Drug Delivery

Advanced Science, 2022
The blood–brain barrier (BBB) severely blocks the intracranial accumulation of most systemic drugs. Inspired by the contribution of the bacterial outer membrane to Escherichia coli K1 (EC‐K1) binding to and invasion of BBB endothelial cells in bacterial ...
Haiyan Chen, Mengyuan Zhou, Yuteng Zeng, Tongtong Miao, Haoyuan Luo, Yang Tong, Mei Zhao, Rui Mu, Jiang Gu, Shudi Yang, Liang Han   +10 more
doaj   +2 more sources

TonB-Dependent Transport Across the Bacterial Outer Membrane [PDF]

Annual Review of Microbiology, 2023
TonB-dependent transporters (TBDTs) are present in all gram-negative bacteria and mediate energy-dependent uptake of molecules that are too scarce or large to be taken up efficiently by outer membrane (OM) diffusion channels. This process requires energy that is derived from the proton motive force and delivered to TBDTs by the TonB-ExbBD motor ...
Augustinas, Silale, Bert, van den Berg
openaire   +3 more sources

Dual recognition of multiple signals in bacterial outer membrane proteins enhances assembly and maintains membrane integrity

eLife
Outer membrane proteins (OMPs) are essential components of the outer membrane of Gram-negative bacteria. In terms of protein targeting and assembly, the current dogma holds that a ‘β-signal’ imprinted in the final β-strand of the OMP engages the β-barrel
Edward M Germany, Nakajohn Thewasano, Kenichiro Imai, Yuki Maruno, Rebecca S Bamert, Christopher J Stubenrauch, Rhys A Dunstan, Yue Ding, Yukari Nakajima, XiangFeng Lai, Chaille T Webb, Kentaro Hidaka, Kher Shing Tan, Hsinhui Shen, Trevor Lithgow, Takuya Shiota   +15 more
doaj   +2 more sources

Antibiotics and hexagonal order in the bacterial outer membrane [PDF]

Nature Communications, 2023
Georgina Benn, Thomas J. Silhavy, Colin Kleanthous, Bart W. Hoogenboom   +3 more
doaj   +2 more sources

A small molecule that disrupts S. Typhimurium membrane voltage without cell lysis reduces bacterial colonization of mice.

PLoS Pathogens, 2022
As pathogenic bacteria become increasingly resistant to antibiotics, antimicrobials with mechanisms of action distinct from current clinical antibiotics are needed.
Jamie L Dombach, Joaquin Lj Quintana, Samual C Allgood, Toni A Nagy, Daniel L Gustafson, Corrella S Detweiler   +5 more
doaj   +1 more source

Bacterial Outer Membrane Vesicles as Antibiotic Delivery Vehicles

Frontiers in Immunology, 2021
Bacterial outer membrane vesicles (OMVs) are nanometer-scale, spherical vehicles released by Gram-negative bacteria into their surroundings throughout growth.
Shannon M. Collins, Angela C. Brown
doaj   +1 more source

The outer membrane phospholipase A is essential for membrane integrity and type III secretion in Shigella flexneri [PDF]

Open Biology, 2016
Outer membrane phospholipase A (OMPLA) is an enzyme located in the outer membrane of Gram-negative bacteria. OMPLA exhibits broad substrate specificity, and some of its substrates are located in the cellular envelope.
Xia Wang, Feng Jiang, Jianhua Zheng, Lihong Chen, Jie Dong, Lilian Sun, Yafang Zhu, Bo Liu, Jian Yang, Guowei Yang, Qi Jin   +10 more
doaj   +1 more source

Murepavadin induces envelope stress response and enhances the killing efficacies of β-lactam antibiotics by impairing the outer membrane integrity of Pseudomonas aeruginosa

Microbiology Spectrum, 2023
Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen that can cause a variety of acute and chronic infections. The bacterium is highly resistant to numerous antibiotics.
Xiaoya Wei, Jiacong Gao, Congjuan Xu, Xiaolei Pan, Yongxin Jin, Fang Bai, Zhihui Cheng, Iain L. Lamont, Daniel Pletzer, Weihui Wu   +9 more
doaj   +1 more source

Biogenesis of the Gram-Negative Bacterial Outer Membrane [PDF]

Annual Review of Microbiology, 2007
The cell envelope of gram-negative bacteria consists of two membranes, the inner and the outer membrane, that are separated by the periplasm. The outer membrane consists of phospholipids, lipopolysaccharides, integral membrane proteins, and lipoproteins.
Bos, M.P., Robert, V.M.V., Tommassen, J.P.M.   +2 more
openaire   +7 more sources

Bacterial outer membrane constriction [PDF]

Molecular Microbiology, 2018
SummaryThe outer membrane of Gram‐negative bacteria is a crucial permeability barrier allowing the cells to survive a myriad of toxic compounds, including many antibiotics. This innate form of antibiotic resistance is compounded by the evolution of more active mechanisms of resistance such as efflux pumps, reducing the already limited number of ...
openaire   +3 more sources