Results 11 to 20 of about 328,822 (337)
A Barrier to Entry: Examining the Bacterial Outer Membrane and Antibiotic Resistance
Applied Sciences, 2023 Gram-negative bacteria can resist antibiotics by changing the permeability via their outer membrane. These bacteria have a complex cell envelope that incorporates an outer membrane separating the periplasm from the external environment.
Ishan Ghai
doaj +2 more sources
Bacterial Outer Membrane Vesicles as Antibiotic Delivery Vehicles
Frontiers in Immunology, 2021 Bacterial outer membrane vesicles (OMVs) are nanometer-scale, spherical vehicles released by Gram-negative bacteria into their surroundings throughout growth.
Shannon M. Collins, Angela C. Brown
doaj +2 more sources
Advanced Science, 2022 The blood–brain barrier (BBB) severely blocks the intracranial accumulation of most systemic drugs. Inspired by the contribution of the bacterial outer membrane to Escherichia coli K1 (EC‐K1) binding to and invasion of BBB endothelial cells in bacterial ...
Haiyan Chen +10 more
doaj +2 more sources
TonB-Dependent Transport Across the Bacterial Outer Membrane
Annual Review of Microbiology, 2023 TonB-dependent transporters (TBDTs) are present in all gram-negative bacteria and mediate energy-dependent uptake of molecules that are too scarce or large to be taken up efficiently by outer membrane (OM) diffusion channels. This process requires energy that is derived from the proton motive force and delivered to TBDTs by the TonB-ExbBD motor ...
Augustinas, Silale, Bert, van den Berg
openaire +3 more sources
Molecular Basis of Bacterial Outer Membrane Permeability Revisited [PDF]
Microbiology and Molecular Biology Reviews, 2003 SUMMARYGram-negative bacteria characteristically are surrounded by an additional membrane layer, the outer membrane. Although outer membrane components often play important roles in the interaction of symbiotic or pathogenic bacteria with their host organisms, the major role of this membrane must usually be to serve as a permeability barrier to prevent
H. Nikaido
openaire +3 more sources
Engineered Bacterial Outer Membrane Vesicles as Multifunctional Delivery Platforms
Frontiers in Materials, 2020 Outer membrane vesicles (OMVs) are valued for their unique, convenient, and amendable functions. They are flexible, controllable nanoparticles, which can be modified in different ways, for use in a wide array of applications like adjuvants, vaccines ...
Ruizhen Li, Qiong Liu, Qiong Liu
doaj +2 more sources
Molecular basis of bacterial outer membrane permeability [PDF]
Microbiological Reviews, 1985 H, Nikaido, M, Vaara
openaire +3 more sources
Versatility of bacterial outer membrane vesicles in regulating intestinal homeostasis
Science Advances, 2023 Outer membrane vesicles (OMVs) play vital roles in bacterial communication both intraspecifically and interspecifically. However, extracellular mechanisms of gut microbiota–derived OMVs in the intestine remain poorly understood. Here, we report that OMVs
Xinyue Wang +7 more
semanticscholar +1 more source
Nature Communications, 2023 Oncolytic adenoviruses (Ads)-mediated anti-tumor activity is related to virus-promoted autophagy in tumor cells. Here the authors describe the design of a microbial nanocomposite based on Ads-encapsulated in bacterial outer membrane vesicles to promote ...
Weiyue Ban +10 more
semanticscholar +1 more source
PLoS Pathogens, 2022 As pathogenic bacteria become increasingly resistant to antibiotics, antimicrobials with mechanisms of action distinct from current clinical antibiotics are needed.
Jamie L Dombach +5 more
doaj +1 more source