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Physical properties of the bacterial outer membrane
Nature Reviews Microbiology, 2021It has long been appreciated that the Gram-negative outer membrane acts as a permeability barrier, but recent studies have uncovered a more expansive and versatile role for the outer membrane in cellular physiology and viability. Owing to recent developments in microfluidics and microscopy, the structural, rheological and mechanical properties of the ...
Steven T Rutherford +2 more
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Construction of nanoantennas on the bacterial outer membrane
Chem. Commun., 2014A simple and highly sensitive detection of pathogenic bacteria is achieved by utilizing gold nanoparticles as an optical antenna.
Hiroshi, Shiigi +13 more
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Architectures of Lipid Transport Systems for the Bacterial Outer Membrane [PDF]
Cell, 2017 How phospholipids are trafficked between the bacterial inner and outer membranes through the hydrophilic space of the periplasm is not known. We report that members of the mammalian cell entry (MCE) protein family form hexameric assemblies with a central channel capable of mediating lipid transport. The E.
Damian C Ekiert +2 more
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Biogenesis of the Gram-negative bacterial outer membrane [PDF]
Current Opinion in Microbiology, 2004 Gram-negative bacteria are bounded by two membranes. The outer membrane consists of phospholipids, lipopolysaccharides, lipoproteins and integral outer membrane proteins, all of which are synthesized in the cytoplasm. Recently, much progress has been made in the elucidation of the mechanisms of transport of these molecules over the inner membrane ...
Jan Tommassen
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Protein oligomerization in the bacterial outer membrane (Review)
Molecular Membrane Biology, 2009The formation of homo-oligomeric assemblies is a well-established characteristic of many soluble proteins and enzymes. Oligomerization has been shown to increase protein stability, allow allosteric cooperativity, shape reaction compartments and provide multivalent interaction sites in soluble proteins. In comparison, our understanding of the prevalence
Guoyu Meng, Remi Fronzes, Han Remaut
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Advances in understanding bacterial outer-membrane biogenesis
Nature Reviews Microbiology, 2006The outer membrane of gram-negative bacteria such as Escherichia coli serves as a protective barrier that controls the influx and efflux of solutes. This allows the bacteria to inhabit several different, and often hostile, environments. The assembly of the E.
Natividad Ruiz +2 more
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Assembly of Bacterial Outer Membrane Proteins
2012Various methods that are routinely used to study the subcellular localization of membrane proteins in wild-type Gram-negative bacteria fall short in genetic studies addressing the biogenesis of outer membrane proteins (OMPs). Here, we describe three biochemical methods that can be used in such studies to evaluate the proper assembly of OMPs into the ...
Grijpstra, J. +2 more
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Insertion of proteins and lipopolysaccharide into the bacterial outer membrane [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2017 The bacterial outer membrane contains phospholipids in the inner leaflet and lipopolysaccharide (LPS) in the outer leaflet. Both proteins and LPS must be frequently inserted into the outer membrane to preserve its integrity. The protein complex that inserts LPS into the outer membrane is called LptDE, and consists of an integral membrane protein, LptD,
Istvan Botos +2 more
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Transport across the bacterial outer membrane
Journal of Bioenergetics and Biomembranes, 1993Diffusion of small molecules across the outer membrane of gram-negative bacteria may occur through protein channels and through lipid bilayer domains. Among protein channels, many examples of trimeric porins, which produce water-filled diffusion channels, are known.
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Assembly and Maintenance of Lipids at the Bacterial Outer Membrane
Chemical Reviews, 2020The outer membrane of Gram-negative bacteria is essential for their survival in harsh environments and provides intrinsic resistance to many antibiotics. This membrane is remarkable; it is a highly asymmetric lipid bilayer. The inner leaflet of the outer membrane contains phospholipids, whereas the fatty acyl chains attached to lipopolysaccharide (LPS)
Emily Lundstedt +2 more
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