Biomimetic "Trojan Horse" delivery of traditional Chinese medicine with immunogenic hybrid vesicles of bacterial outer membrane and tumor cell membrane for synergistic chemo-immunotherapy of liver cancers. [PDF]
Zhao Z, Luo L, Wang Z, Guo B, Gao C.
europepmc +1 more source
Gram-Negative Bacterial Outer Membrane Vesicles Inhibit Growth of Multidrug-Resistant Organisms and Induce Wound-Healing Cytokines [PDF]
Sarah M. Baker +2 more
openalex +1 more source
Painting Peptides With Antimicrobial Potency Through Deep Reinforcement Learning
AMPainter is a powerful design model for ’painting’ the antimicrobial potency on any given peptide sequence, based on the strategy of virtual directed evolution and deep reinforcement learning. Abstract In the post‐antibiotic era, antimicrobial peptides (AMPs) are considered ideal drug candidates because of their lower likelihood of inducing resistance.
Ruihan Dong, Qiushi Cao, Chen Song
wiley +1 more source
Chimeric Nanozyme Bacterial Outer Membrane Vesicles Reprograming Tumor Microenvironment for Safe and Efficient Anticancer Therapy. [PDF]
Zhang F +11 more
europepmc +1 more source
Using nano‐flow cytometry, this study analyzes the dynamic characteristics of lipoteichoic acid (LTA) and/or lipopolysaccharide (LPS) positive extracellular vesicles in the bloodstream of patients with bacterial infections, providing promising biomarkers for rapid and accurate diagnosis.
Qianqian Gao +10 more
wiley +1 more source
SIP‐SRS Imaging of Cell Wall Synthesis Identifies a Synergy between Micafungin and Amphotericin B
We employed glucose‐d7–based stable isotope probe‐assisted SRS microscopy (SIP‐SRS) C–D imaging to visualize fungal cell wall synthesis and remodeling under antifungal treatment. Amphotericin B (AmB) induced notable daughter cell wall thickening, prompting a combinational therapy with AmB and micafungin.
Meng Zhang +6 more
wiley +1 more source
Nanobody Engineered and Photosensitiser Loaded Bacterial Outer Membrane Vesicles Potentiate Antitumour Immunity and Immunotherapy. [PDF]
Xia P +13 more
europepmc +1 more source
Small RNA Regulation of TolC, the Outer Membrane Component of Bacterial Multidrug Transporters [PDF]
Ashley Parker, Susan Gottesman
openalex +1 more source
This study presents a refined adaptive laboratory evolution (ALE) strategy to resolve the trade‐off between tolerance and biosynthetic efficiency in toxic chemical production. Combining in vivo mutagenesis, microdroplet‐based evolution, and biosensor‐assisted selection, this strategy rapidly yields robust “win‐win” phenotypes.
Yufei Zhang +7 more
wiley +1 more source

