Results 71 to 80 of about 273,841 (296)
Communications BiologyPolymyxins are often administered as last resort antibiotics for Gram-negative bacterial infections. However, given unwanted side-effects, efficacy and recent reports of resistance against polymyxins, there is an urgency to develop alternatives.
Dheeraj Prakaash, Syma Khalid
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Domain organization of long autotransporter signal sequences [PDF]
, 2010 Bacterial autotransporters represent a diverse family of proteins that autonomously translocate across the inner membrane of Gram-negative bacteria via the Sec complex and across the outer bacterial membrane.
Hiß, Jan Alexander +1 more
core +1 more source
Chlamydial infection from outside to inside [PDF]
, 2019 Chlamydia are obligate intracellular bacteria, characterized by a unique biphasic developmental cycle. Specific interactions with the host cell are crucial for the bacteria's survival and amplification because of the reduced chlamydial genome.
Gitsels, Arlieke +2 more
core +2 more sources
Analyzing the molecular mechanism of lipoprotein localization in Brucella
Frontiers in Microbiology, 2015 Bacterial lipoproteins possess comprehensive structure and functionality, ranging from bacterial physiology to pathogenic processes. As such many lipoproteins, originating from Brucella are exploited as potential vaccines to countermeasure brucellosis ...
Shivani eGoolab +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Biogenesis of mitochondrial c-type cytochromes [PDF]
, 1990 Cytochromesc andc 1 are essential components of the mitochondrial respiratory chain. In both cytochromes the heme group is covalently linked to the polypeptide chain via thioether bridges. The location of the two cytochromes is in the intermembrane space;
Gonzales, Daniel H., Neupert, Walter
core +2 more sources
Membrane Protein Simulations: Ion Channels And Bacterial Outer Membrane Proteins
, 2003 Publisher Summary The chapter focuses on two classes that have been investigated by a number of research groups—namely, ion channels and bacterial outer membrane proteins—rather than attempt to cover all simulations of membrane proteins. Ion channels play a key role in the electrical activity of cells of the nervous system. However, channels are also
Domene, Carmen +2 more
openaire +3 more sources
Chaperone Spy Protects Outer Membrane Proteins from Folding Stress via Dynamic Complex Formation
mBio, 2021 Outer membrane proteins (OMPs) play critical roles in bacterial pathogenicity and provide a new niche for antibiotic development. A comprehensive understanding of the OMP quality control network will strongly impact antimicrobial discovery.
Wei He +11 more
doaj +1 more source