Results 61 to 70 of about 3,626,493 (277)

Antimicrobial activity and mode of action of terpene linalyl anthranilate against carbapenemase-producing Klebsiella pneumoniae

Journal of Pharmaceutical Analysis, 2021
Mining of plant-derived antimicrobials is the major focus at current to counter antibiotic resistance. This study was conducted to characterize the antimicrobial activity and mode of action of linalyl anthranilate (LNA) against carbapenemase-producing ...
Shun-Kai Yang, Khatijah Yusoff, Mokrish Ajat, Wai-Sum Yap, Swee-Hua Erin Lim, Kok-Song Lai   +5 more
doaj   +1 more source

Structure and function of bacterial outer membrane proteins: barrels in a nutshell [PDF]

Molecular Microbiology, 2000
The outer membrane protects Gram‐negative bacteria against a harsh environment. At the same time, the embedded proteins fulfil a number of tasks that are crucial to the bacterial cell, such as solute and protein translocation, as well as signal transduction.
Koebnik, Ralf, Locher, Kaspar, van Gelder, Patrick   +2 more
openaire   +3 more sources

Identification and Structural Characterisation of Novel Outer Membrane Proteins in the genus Borrelia [PDF]

Although considered Gram-negative the outer membrane (OM) of Borrelia is unique, consisting of a variety of glycolipids, a significant number of surface exposed lipoproteins and a smaller number of integral membrane-spanning β-barrels.
Dyer, Adam
core   +3 more sources

Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins

mBio, 2017
The Gram-negative bacterial cell wall component lipopolysaccharide (LPS) is recognized by the noncanonical inflammasome protein caspase-11 in the cytosol of infected host cells and thereby prompts an inflammatory immune response linked to sepsis.
Ryan Finethy, Sarah Luoma, Nichole Orench-Rivera, Eric M. Feeley, Arun K. Haldar, Masahiro Yamamoto, Thirumala-Devi Kanneganti, Meta J. Kuehn, Jörn Coers   +8 more
doaj   +1 more source

Reconstitution of a nanomachine driving the assembly of proteins into bacterial outer membranes [PDF]

Nature Communications, 2014
In biological membranes, various protein secretion devices function as nanomachines, and measuring the internal movements of their component parts is a major technological challenge. The translocation and assembly module (TAM) is a nanomachine required for virulence of bacterial pathogens. We have reconstituted a membrane containing the TAM onto a gold
Shen, Hsin-Hui, Leyton, Denisse, Shiota, Takuya, Belousoff, Matthew J, Noinaj, Nicholas, Lu, Jingxiong, Holt, Stephen A., Tan, Kershing, Selkrig, Joel, Webb, Chaille T., Buchanan, Susan K., Martin, Lisandra, Lithgow, Trevor   +12 more
openaire   +3 more sources

Mucin adsorbed by E. coli can affect neutrophil activation in vitro

FEBS Open Bio, 2020
Bacteria colonizing human intestine adhere to the gut mucosa and avoid the innate immune system. We previously demonstrated that Escherichia coli isolates can adsorb mucin from a diluted solution in vitro.
Elena Mikhalchik, Nadezhda Balabushevich, Tatiana Vakhrusheva, Alexey Sokolov, Julia Baykova, Daria Rakitina, Petr Scherbakov, Sergey Gusev, Alexander Gusev, Zaira Kharaeva, Olga Bukato, Olga Pobeguts   +11 more
doaj   +1 more source

The Landscape of Pseudomonas aeruginosa Membrane-Associated Proteins

Cells, 2020
Background: Pseudomonas aeruginosa cell envelope-associated proteins play a relevant role in infection mechanisms. They can contribute to the antibiotic resistance of the bacterial cells and be involved in the interaction with host cells.
Sara Motta, Davide Vecchietti, Alessandra M. Martorana, Pietro Brunetti, Giovanni Bertoni, Alessandra Polissi, Pierluigi Mauri, Dario Di Silvestre   +7 more
doaj   +1 more source

Folding of a bacterial integral outer membrane protein is initiated in the periplasm [PDF]

Nature Communications, 2017
AbstractThe Bam complex promotes the insertion of β-barrel proteins into the bacterial outer membrane, but it is unclear whether it threads β-strands into the lipid bilayer in a stepwise fashion or catalyzes the insertion of pre-folded substrates.
Rakesh Sikdar, Janine H. Peterson, D. Eric Anderson, Harris D. Bernstein   +3 more
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Polymyxins slow down lateral diffusion of proteins and lipopolysaccharide in the E. coli outer membrane

Communications Biology
Polymyxins are often administered as last resort antibiotics for Gram-negative bacterial infections. However, given unwanted side-effects, efficacy and recent reports of resistance against polymyxins, there is an urgency to develop alternatives.
Dheeraj Prakaash, Syma Khalid
doaj   +1 more source