Anticancer Activity of Bacterial Proteins and Peptides [PDF]
Pharmaceutics, 2018 Despite much progress in the diagnosis and treatment of cancer, tumour diseases constitute one of the main reasons of deaths worldwide. The side effects of chemotherapy and drug resistance of some cancer types belong to the significant current ...
Tomasz M. Karpiński, Artur Adamczak
doaj +3 more sources
Deep mutational scanning of essential bacterial proteins can guide antibiotic development. [PDF]
Nat Commun, 2023 Deep mutational scanning can be used to investigate protein function and stability. Here, Dewachter et al. use deep mutational scanning on three essential bacterial proteins to study the mutations’ effects in their original genomic context, providing ...
Dewachter L +10 more
europepmc +2 more sources
Enzymatic Labeling of Bacterial Proteins for Super-resolution Imaging in Live Cells. [PDF]
ACS Cent Sci, 2019 Methods that enable the super-resolution imaging of intracellular proteins in live bacterial cells provide powerful tools for the study of prokaryotic cell biology.
Ho SH, Tirrell DA.
europepmc +2 more sources
Functional and structural characteristics of bacterial proteins that bind host cytokines. [PDF]
Virulence, 2017 Several human pathogens bind and respond to host cytokines, which can be considered a virulence mechanism that communicates defensive actions of the host to the pathogen. This review summarizes the current knowledge of bacterial cytokine-binding proteins,
Högbom M, Ihalin R.
europepmc +2 more sources
Visualizing the invisible: novel approaches to visualizing bacterial proteins and host-pathogen interactions [PDF]
Frontiers in Bioengineering and BiotechnologyHost-pathogen interactions play a critical role in infectious diseases, and understanding the underlying mechanisms is vital for developing effective therapeutic strategies.
Moirangthem Kiran Singh +2 more
doaj +2 more sources
The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection. [PDF]
mBio, 2017 Exported proteins of bacterial pathogens function both in essential physiological processes and in virulence. Past efforts to identify exported proteins were limited by the use of bacteria growing under laboratory (in vitro) conditions.
Perkowski EF +8 more
europepmc +2 more sources
Detection of Antimicrobial Proteins/Peptides and Bacterial Proteins Involved in Antimicrobial Resistance in Raw Cow’s Milk from Different Breeds [PDF]
AntibioticsProteins involved in antibiotic resistance (resistome) and with antimicrobial activity are present in biological specimens. This study aims to explore the presence and abundance of antimicrobial peptides (AMPs) and resistome proteins in bovine milk from ...
Cristian Piras +8 more
doaj +2 more sources
Bacterial proteins and peptides in cancer therapy: today and tomorrow. [PDF]
Bioengineered, 2014 Cancer is one of the most deadly diseases worldwide. In the last three decades many efforts have been made focused on understanding how cancer grows and responds to drugs.
Chakrabarty AM, Bernardes N, Fialho AM.
europepmc +2 more sources
Formyl-methionine as a degradation signal at the N-termini of bacterial proteins. [PDF]
Microb Cell, 2015 In bacteria, all nascent proteins bear the pretranslationally formed N-terminal formyl-methionine (fMet) residue. The fMet residue is cotranslationally deformylated by a ribosome-associated deformylase.
Piatkov KI +3 more
europepmc +2 more sources
Acetylated bacterial proteins as potent antigens inducing an anti-modified protein antibody response [PDF]
RMD OpenObjective Gut-residing bacteria, such as Escherichia coli, can acetylate their proteome under conditions of amine starvation. It is postulated that the (gut) microbiome is involved in the breach of immune tolerance to modified self-proteins leading to ...
Tom W J Huizinga +9 more
doaj +2 more sources