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Visualizing the invisible: novel approaches to visualizing bacterial proteins and host-pathogen interactions [PDF]

Frontiers in Bioengineering and Biotechnology
Host-pathogen interactions play a critical role in infectious diseases, and understanding the underlying mechanisms is vital for developing effective therapeutic strategies.
Moirangthem Kiran Singh, Linda J. Kenney, Linda J. Kenney   +2 more
doaj   +2 more sources

Detection of Antimicrobial Proteins/Peptides and Bacterial Proteins Involved in Antimicrobial Resistance in Raw Cow’s Milk from Different Breeds [PDF]

Antibiotics
Proteins involved in antibiotic resistance (resistome) and with antimicrobial activity are present in biological specimens. This study aims to explore the presence and abundance of antimicrobial peptides (AMPs) and resistome proteins in bovine milk from ...
Cristian Piras, Rosario De Fazio, Antonella Di Francesco, Francesca Oppedisano, Anna Antonella Spina, Vincenzo Cunsolo, Paola Roncada, Rainer Cramer, Domenico Britti   +8 more
doaj   +2 more sources

Anticancer Activity of Bacterial Proteins and Peptides [PDF]

Pharmaceutics, 2018
Despite much progress in the diagnosis and treatment of cancer, tumour diseases constitute one of the main reasons of deaths worldwide. The side effects of chemotherapy and drug resistance of some cancer types belong to the significant current ...
Tomasz M. Karpiński, Artur Adamczak
doaj   +2 more sources

Synthesized Geopolymers Adsorb Bacterial Proteins, Toxins, and Cells [PDF]

Frontiers in Bioengineering and Biotechnology, 2020
Pore-forming and hemolytic toxins are bacterial cytotoxic proteins required for virulence in many pathogens, including staphylococci and streptococci, and are notably associated with clinical manifestations of disease.
John Popovich, Shaojiang Chen, Natalie Iannuzo, Natalie Iannuzo, Collin Ganser, Collin Ganser, Dong-Kyun Seo, Dong-Kyun Seo, Shelley E. Haydel, Shelley E. Haydel, Shelley E. Haydel   +10 more
doaj   +2 more sources

Acetylated bacterial proteins as potent antigens inducing an anti-modified protein antibody response [PDF]

RMD Open
Objective Gut-residing bacteria, such as Escherichia coli, can acetylate their proteome under conditions of amine starvation. It is postulated that the (gut) microbiome is involved in the breach of immune tolerance to modified self-proteins leading to ...
Tom W J Huizinga, Diane van der Woude, René E M Toes, Mikhail Volkov, Peter A van Veelen, Joanneke C Kwekkeboom, Karin A J van Schie, Arieke S B Kampstra, Anouk G van Mourik, Arnoud de Ru   +9 more
doaj   +2 more sources

High-Throughput Virtual Screening of Compounds with Electrophilic Fragments for New Potential Covalent Inhibitors of Bacterial Proteins

Chemistry Proceedings, 2022
The search for new antibacterial drugs has continued to be an urgent matter. One of the approaches is the development of covalent inhibitors using biochemoinformatics at the initial stages.
Polina Yakovets, Viktoryia Staravoitava, Yaroslav Faletrov, Vladimir Shkumatov   +3 more
doaj   +1 more source

Potential Probiotic Pediococcus pentosaceus M41 Modulates Its Proteome Differentially for Tolerances Against Heat, Cold, Acid, and Bile Stresses

Frontiers in Microbiology, 2021
Probiotics containing functional food confer health benefits in addition to their nutritional properties. In this study, we have evaluated the differential proteomic responses of a potential novel probiotic Pediococcus pentosaceus M41 under heat, cold ...
Mohd Affan Baig, Mark S. Turner, Shao-Quan Liu, Anas A. Al-Nabulsi, Nagendra P. Shah, Mutamed M. Ayyash   +5 more
doaj   +1 more source

The Role of Outer Membrane Proteins in UPEC Antimicrobial Resistance: A Systematic Review

Membranes, 2022
Uropathogenic Escherichia coli (UPEC) are one of the most common agents of urinary tract infection. In the last decade, several UPEC strains have acquired antibiotic resistance mechanisms and some have become resistant to all classes of antibiotics. UPEC
Inês C. Rodrigues, Sílvia C. Rodrigues, Filipe V. Duarte, Paula M. da Costa, Paulo M. da Costa   +4 more
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The Manifold Bioactivity and Immunoreactivity of Microbial Proteins of Cow and Human Mature Milk in Late Lactation

Animals, 2022
(1) Human milk (HM) is a source of many microorganisms, whose structure contains microbial protein (MP). In addition to the known health-promoting properties of HM, many activities, including immunoreactivity, may result from the presence of MP.
Anna Maria Ogrodowczyk, Maja Jeż, Barbara Wróblewska   +2 more
doaj   +1 more source

How Quickly Do Proteins Fold and Unfold, and What Structural Parameters Correlate with These Values?

Biomolecules, 2020
The correlations between the logarithm of the unfolding rate of 108 proteins and their structural parameters were calculated. We showed that there is a good correlation between the logarithm of folding and unfolding rates (0.79) and protein stability and
Anna V. Glyakina, Oxana V. Galzitskaya
doaj   +1 more source