HELICOBACTER PYLORI OIPA VIRULENCE GENE AS A MOLECULAR MARKER OF SEVERE GASTROPATHIES [PDF]
Arquivos de GastroenterologiaBackground: Helicobacter pylori is an etiologic agent of gastroduodenal diseases. The microorganism, considered a type I carcinogen, affects about 50% of the global population. H.
Diogo Nery MACIEL +4 more
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Bacterial Drug Efflux Proteins.
Nippon Saikingaku Zasshi, 1995 近年,数多くの薬剤排出系が様々な菌種に見いだされ,有力な化学療法剤耐性機構として認識されつつある。特に,臨床上問題視されているMRSAや緑膿菌などの多剤耐性菌に薬剤排出蛋白が多く存在することは注目すべきである。遺伝子解析により多くの排出蛋白のアミノ酸配列が明らかにされた。薬剤排出蛋白はいずれも細胞質膜に存在するが,薬剤排出のエネルギー源として,H+の電気化学的勾配を用いるものと,ATPを用いるものと2種類ある。また,構造上関連性のない多種の薬剤を認識し排出する多剤排出蛋白の存在が排出による薬剤耐性のひとつの特徴であるが,特異性の高い排出蛋白との間で一次配列の相同性が高く,多剤排出蛋白がどのように基質を認識しているのか興味が持たれる ...
Y, Someya, A, Yamaguchi
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Coxiella burnetii Blocks Intracellular Interleukin-17 Signaling in Macrophages [PDF]
, 2018 Coxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever. Successful host cell infection requires the Coxiella type IVB secretion system (T4BSS), which translocates bacterial effector proteins across the vacuole ...
Clemente, Tatiana M. +5 more
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ENGINEERED FLUORESCENT PROTEINS ILLUMINATE THE BACTERIAL PERIPLASM
Computational and Structural Biotechnology Journal, 2012 The bacterial periplasm is of special interest whenever cell factories are designed and engineered. Recombinantely produced proteins are targeted to the periplasmic space of Gram negative bacteria to take advantage of the authentic N-termini, disulfide ...
Thorben Dammeyer, Philip Tinnefeld
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In vitro and in vivo screening for novel essential cell-envelope proteins in Pseudomonas aeruginosa [PDF]
, 2015 The Gram-negative bacterium Pseudomonas aeruginosa represents a prototype of multi-drug resistant opportunistic pathogens for which novel therapeutic options are urgently required.
Bragonzi, Alessandra +5 more
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Exploring the mechanisms by which camel lactoferrin can kill Salmonella enterica serovar typhimurium and Shigella sonnei [PDF]
PeerJ, 2023 There is a continuously increasing pressure associated with the appearance of Salmonella enterica Serovar typhimurium (S. typhimurium) and Shigella sonnei (S.
Hussein A. Almehdar +7 more
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Structure and sequence analyses of Bacteroides proteins BVU_4064 and BF1687 reveal presence of two novel predominantly-beta domains, predicted to be involved in lipid and cell surface interactions. [PDF]
, 2015 BackgroundN-terminal domains of BVU_4064 and BF1687 proteins from Bacteroides vulgatus and Bacteroides fragilis respectively are members of the Pfam family PF12985 (DUF3869).
Aravind, L +5 more
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Role of glutathionylation in infection and inflammation [PDF]
, 2019 Glutathionylation, that is, the formation of mixed disulfides between protein cysteines and glutathione (GSH) cysteines, is a reversible post-translational modification catalyzed by dierent cellular oxidoreductases, by which the redox state of the cell
Baldelli, S. +5 more
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Type VI secretion: a beginner's guide [PDF]
, 2008 Type VI secretion is a newly described mechanism for protein transport across the cell envelope of Gram-negative bacteria. Components that have been partially characterised include an IcmF homologue, the ATPase ClpV, a regulatory FHA domain protein and ...
Akeda +47 more
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PLoS Biology, 2023 Animals use a variety of cell-autonomous innate immune proteins to detect viral infections and prevent replication. Recent studies have discovered that a subset of mammalian antiviral proteins have homology to antiphage defense proteins in bacteria ...
Edward M Culbertson, Tera C Levin
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