Results 231 to 240 of about 1,037,757 (288)

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

open access: yesAdvanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl   +20 more
wiley   +1 more source

BTXpred: Prediction of Bacterial Toxins

open access: yesIn Silico Biology, 2007
This paper describes a method developed for predicting bacterial toxins from their amino acid sequences. All the modules, developed in this study, were trained and tested on a non-redundant dataset of 150 bacterial toxins that included 77 exotoxins and 73 endotoxins. Firstly, support vector machines (SVM) based modules were developed for predicting the
Sudipto Saha, Gajendra Raghava
exaly   +4 more sources
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Toxins: Bacterial and Marine Toxins

Clinics in Laboratory Medicine, 2006
The term toxin refers in a specific way to a toxic substance of biologic origin; that is, a true toxin is a poison produced by a living organism. The purpose of this article is to review some of the most potentially dangerous toxins of concern today. Mechanisms of action, routes of exposure, diagnostic tools, and treatment recommendations are addressed.
Matthew, Salzman   +2 more
openaire   +2 more sources

Bacterial Toxins and Diarrhoea

Clinics in Gastroenterology, 1986
Bacteria and their toxins are responsible for an enormous burden of diarrhoeal disease. Knowledge about the toxins and their mechanisms of action is limited. Thus, although considerable information is available about the mechanism of action of cholera toxin and a small number of heat-stable enterotoxins, information on the role and action of many ...
K J, Moriarty, L A, Turnberg
openaire   +2 more sources

The bacterial toxin toolkit

Nature Reviews Molecular Cell Biology, 2001
Pathogenic bacteria and higher eukaryotes have spent a long time together, leading to a precise understanding of one another's way of functioning. Through rapid evolution, bacteria have engineered increasingly sophisticated weapons to hit exactly where it hurts, interfering with fundamental host functions.
G, Schiavo, F G, van der Goot
openaire   +2 more sources

Bacterial toxin vaccines

Vaccine, 1985
A rebirth of interest and activity in vaccine development has occurred in recent years which is probably due to the persistence of threat to health by infectious diseases, as well as technological advances which have made possible new approaches to solve old problems.
F, Dorner, J L, McDonel
openaire   +2 more sources

Bacterial Insecticidal Toxins

Critical Reviews in Microbiology, 2004
Over the years it has been important for humans to control the populations of harmful insects and insecticides have been used for this purpose in agricultural and horticultural sectors. Synthetic insecticides, owing to their various side effects, have been widely replaced by biological insecticides. In this review we attempt to describe three bacterial
Abanti, Chattopadhyay   +2 more
openaire   +2 more sources

Targeting Bacterial Toxins

Angewandte Chemie International Edition, 2012
AbstractProtein toxins constitute the main virulence factors of several species of bacteria and have proven to be attractive targets for drug development. Lead candidates that target bacterial toxins range from small molecules to polymeric binders, and act at each of the multiple steps in the process of toxin‐mediated pathogenicity.
Ivarsson ME, Leroux JC, Castagner B
openaire   +3 more sources

Bacterial Toxins as Immunomodulators

2009
Bacterial toxins are the causative agent at pathology in a variety of diseases. Although not always the primary target of these toxins, many have been shown to have potent immunomodulatory effects, for example, inducing immune responses to co-administered antigens and suppressing activation of immune cells.
David S, Donaldson, Neil A, Williams
openaire   +2 more sources

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