Results 131 to 140 of about 94,986 (281)

The neglected model validation of antimicrobial resistance transmission models – a systematic review

Antimicrobial Resistance and Infection Control
Background In the fight against antimicrobial resistance, mathematical transmission models have been shown as a valuable tool to guide intervention strategies in public health.
Maja L. Brinch, Andrea Palladino, Jeroen Geurtsen, Thierry Van Effelterre, Lorenzo Argante, Michael J. McConnell, Lene Christiansen, Michelle A. Pihl, Natasja K. Lund, Tine Hald   +9 more
doaj   +1 more source

Immunological Insights and Therapeutic Advances in COPD: Exploring Oral Bacterial Vaccines for Immune Modulation and Clinical Improvement

Vaccines
Chronic obstructive pulmonary disease (COPD) is a prevalent chronic condition associated with substantial global morbidity and mortality. Primarily caused by prolonged exposure to harmful agents such as dust and gases, COPD is characterized by persistent
Sławomir Lewicki, Barbara Joanna Bałan, Marta Stelmasiak, Dorota Magdalena Radomska-Leśniewska, Łukasz Szymański, Natalia Rios-Turek, Justyna Bień-Kalinowska, Łukasz Szarpak, Bogdan Hajduk   +8 more
doaj   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

RUNT DISEASE INDUCED IN NEONATAL MICE BY STERILE BACTERIAL VACCINES [PDF]

, 1964
Richard D. Ekstedt, Edwin T. Nishimura
openalex   +1 more source

PRO‐LDM: A Conditional Latent Diffusion Model for Protein Sequence Design and Functional Optimization

Advanced Science, EarlyView.
PRO‐LDM is a modular latent diffusion framework that learns hierarchical biological representations to enable efficient and high‐fidelity protein design. PRO‐LDM can design species that resemble natural sequences with enhanced diversity or optimize protein functions.
Sitao Zhang, Zixuan Jiang, Rundong Huang, Wenting Huang, Siyuan Peng, Shaoxun Mo, Letao Zhu, Peiheng Li, Ziyi Zhang, Emily Pan, Xi Chen, Yunfei Long, Qi Liang, Jin Tang, Renjing Xu, Rui Qing   +15 more
wiley   +1 more source

Size-Dependent Antibacterial Immunity of Staphylococcus aureus Protoplast-Derived Particulate Vaccines

International Journal of Nanomedicine, 2020
Xuelian Fan,1 Fei Wang,1 Xin Zhou,1 Bin Chen,2 Gang Chen1 1Institute of Comparative Medicine, College of Veterinary Medicine, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Joint ...
Fan X, Wang F, Zhou X, Chen B, Chen G
doaj  

Identification and characterisation of toxin-antitoxin systems (TA) in Burkholderia pseudomallei [PDF]

, 2013
The aim of this study was to identify and characterise type II toxin-antitoxin (TA) systems in Burkholderia pseudomallei, the causative agent of the human disease melioidosis. 8 putative TA systems were identified within the genome of B. pseudomallei
Butt, Aaron Trevor
core  

Bacterial Vaccine in Multidose Tablet Form for Parenteral Use [PDF]

, 1963
Sanford Berman, Joseph P. Lowenthal, Earl W. Grogan, Patricia L. Altieri, Abram S. Benenson   +4 more
openalex   +1 more source

Cryogel‐Based Dendritic Cell Immunotherapy for Post‐Surgical Breast Cancer Treatment

Advanced Science, EarlyView.
A multifunctional GelMA cryogel enables dendritic cell immunotherapy that synergizes with doxorubicin and PD‐1 blockade, driving robust post‐surgical T‐cell immunity and suppressing TNBC recurrence. Abstract Triple‐negative breast cancer (TNBC) is an aggressive malignancy with high mortality and limited treatment options.
Lam‐Duc‐Huy Nguyen, Sheng‐Liang Cheng, Yu‐Ting Yen, Hsin‐Mei Lee, Te‐Haw Wu, Jane Wang, Shu‐Yi Lin, Yunching Chen   +7 more
wiley   +1 more source

Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer

Advanced Science, EarlyView.
We show that intratumoral release of an immunotherapy—CpG —can be tuned with molecular precision by complexing it to an elastin‐like polypeptide (ELP). Injecting ELP‐CpG and an excipient ELP into tumors drives thermally‐triggered phase separation into a micro‐scale “sponge” depot that releases CpG at rates depending on the ELP composition, which ...
Joshua J. Milligan, Rachel L. Strader, Arunangshu Chakrabarty, Max Ney, Parul Sirohi, Jonathan C. Su, Anastasia K. Varanko, Yulia Shmidov, Kalina Tsolova, Cassio Mendes Fontes, Anna Finkelstein, Rohinee Mattikalli, Yun‐Xing Wang, Lixin Fan, Xinghai Li, Smita K. Nair, Ashutosh Chilkoti   +16 more
wiley   +1 more source