Results 61 to 70 of about 3,443 (171)

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

Investigation of Recombinantly Produced Endolysins Reveals a Modular Enzyme Shared by Several Enterobacteria Phages to Exhibit Broad‐Range Lytic Activity Against Different Orders of Gammaproteobacteria

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
The recombinant endolysin El1 derived from Enterobacteria bacteriophages showed potent bactericidal activity against Gram‐negative bacteria when applied exogenously, even in the absence of membrane‐permeabilizing agents, such as ethylenediaminetetraacetic acid (EDTA).
Tatjana Kazaka, Nikita Zrelovs, Inara Akopjana, Janis Bogans, Juris Jansons, Andris Dislers, Andris Kazaks   +6 more
wiley   +1 more source

Discovery of a family of menaquinone-targeting cyclic lipodepsipeptides for multidrug-resistant Gram-positive pathogens

Communications Biology
Menaquinone (MK) in bacterial membrane is an attractive target for the development of novel therapeutic agents. Mining the untapped chemical diversity encoded by Gram-negative bacteria presents an opportunity to identify additional MK-binding antibiotics
Runze Sun, Di Zhao, Xuchang Yu, Fei Zhang, Ruixiang You, Xiaoxia Luo, Lei Li   +6 more
doaj   +1 more source

Synergistic Activity of Fosfomycin, Ciprofloxacin, and Gentamicin Against Escherichia coli and Pseudomonas aeruginosa Biofilms

Frontiers in Microbiology, 2019
Gram-negative (GN) rods cause about 10% periprosthetic joint infection (PJI) and represent an increasing challenge due to emergence of antimicrobial resistance.
Lei Wang, Lei Wang, Mariagrazia Di Luca, Tamta Tkhilaishvili, Tamta Tkhilaishvili, Andrej Trampuz, Andrej Trampuz, Mercedes Gonzalez Moreno, Mercedes Gonzalez Moreno   +8 more
doaj   +1 more source

Cellulose‐Based Nanocomposites in Drug Delivery and Antimicrobial Therapies: Emerging Innovations and Translational Outlook

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
Applications of cellulose‐based nanocomposites in antimicrobial drug delivery. ABSTRACT Cellulose‐based nanocomposites have emerged as sustainable and versatile biomaterials with promising applications in drug delivery and antimicrobial therapy.
Suraj Kumar, Rishabha Malviya, Sathvik Belagodu Sridhar, Tarun Wadhwa, Javedh Shareef   +4 more
wiley   +1 more source

Comparative Evaluation of qnrA, qnrB, and qnrS Genes in Enterobacteriaceae Ciprofloxacin-Resistant Cases, in Swine Units and a Hospital from Western Romania

Antibiotics, 2020
Excessive use of antimicrobials and inadequate infection control practices has turned antimicrobial resistance (AMR) into a global, public health peril. We studied the expression of qnrA, qnrB, and qnrS plasmid in ciprofloxacin (CIP)-resistant strains of
Alexandru O. Doma, Roxana Popescu, Mihai Mitulețu, Delia Muntean, János Dégi, Marius V. Boldea, Isidora Radulov, Eugenia Dumitrescu, Florin Muselin, Nikola Puvača, Romeo T. Cristina   +10 more
doaj   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, Volume 22, Issue 16, 17 March 2026.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Beyond bacterial defences: the role of lysozyme in cancer

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Lysozyme (LYZ) is a multi‐functional secreted factor that encompasses both antibacterial and immunomodulatory functions. Emerging evidence highlights its complex role in tumour progression by directly influencing tumour cells and modulating the immune microenvironment.
Lei Wang, Qian Dong, Fuchu He, Zhiwen Gu, Aihua Sun   +4 more
wiley   +1 more source

Chlamydiaphage φCPG1 Capsid Protein Vp1 Inhibits Chlamydia trachomatis Growth via the Mitogen-Activated Protein Kinase Pathway

Viruses, 2016
Chlamydia trachomatis is the most common cause of curable bacterial sexually transmitted infections worldwide. Although the pathogen is well established, the pathogenic mechanisms remain unclear.
Yuanli Guo, Rui Guo, Quan Zhou, Changgui Sun, Xinmei Zhang, Yuanjun Liu, Quanzhong Liu   +6 more
doaj   +1 more source

A stealth adhesion factor contributes to Vibrio vulnificus pathogenicity: Flp pili play roles in host invasion, survival in the blood stream and resistance to complement activation.

PLoS Pathogens, 2019
The tad operons encode the machinery required for adhesive Flp (fimbrial low-molecular-weight protein) pili biogenesis. Vibrio vulnificus, an opportunistic pathogen, harbors three distinct tad loci.
Tra-My Duong-Nu, Kwangjoon Jeong, Seol Hee Hong, Sao Puth, Soo Young Kim, Wenzhi Tan, Kwang Ho Lee, Shee Eun Lee, Joon Haeng Rhee   +8 more
doaj   +1 more source