Results 61 to 70 of about 3,337 (166)

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

open access: yesSmall, Volume 22, Issue 16, 17 March 2026.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti   +5 more
wiley   +1 more source

Beyond bacterial defences: the role of lysozyme in cancer

open access: yesClinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Lysozyme (LYZ) is a multi‐functional secreted factor that encompasses both antibacterial and immunomodulatory functions. Emerging evidence highlights its complex role in tumour progression by directly influencing tumour cells and modulating the immune microenvironment.
Lei Wang   +4 more
wiley   +1 more source

Dual‐function, Reusable, and Flexible Thermal Interface for Kinetic Monitoring of In Vitro Bioassays

open access: yesSmall Methods, Volume 10, Issue 3, 9 February 2026.
This work presents a reusable, dual‐function thermal interface for non‐contact, label‐free sensing and microwell‐independent temperature control in microplates within a single element. Real‐time monitoring of E. coli growth and the response to antibiotic treatment demonstrates the sensor's enhanced sensitivity in interface‐dominated processes compared ...
Daniel Nieder   +4 more
wiley   +1 more source

Synergistic Activity of Fosfomycin, Ciprofloxacin, and Gentamicin Against Escherichia coli and Pseudomonas aeruginosa Biofilms

open access: yesFrontiers in Microbiology, 2019
Gram-negative (GN) rods cause about 10% periprosthetic joint infection (PJI) and represent an increasing challenge due to emergence of antimicrobial resistance.
Lei Wang   +8 more
doaj   +1 more source

Transgenic Tobacco Plants Expressing Synthetic Peptides: A Functional and Structural Analysis for Pathogen Resistance

open access: yesPlant Biotechnology Journal, Volume 24, Issue 2, Page 526-546, February 2026.
Peptide Power: VR18 & KG18 Shield Tobacco from Bacterial Attack. A schematic shows how antimicrobial peptides VR18 and KG18 fight Pseudomonas syringae—bursting bacterial membranes and boosting disease resistance in transgenic tobacco, without harming plant health.
Karishma Biswas   +17 more
wiley   +1 more source

Comparative Evaluation of qnrA, qnrB, and qnrS Genes in Enterobacteriaceae Ciprofloxacin-Resistant Cases, in Swine Units and a Hospital from Western Romania

open access: yesAntibiotics, 2020
Excessive use of antimicrobials and inadequate infection control practices has turned antimicrobial resistance (AMR) into a global, public health peril. We studied the expression of qnrA, qnrB, and qnrS plasmid in ciprofloxacin (CIP)-resistant strains of
Alexandru O. Doma   +10 more
doaj   +1 more source

Insect I‐Type Lysozymes Function as Antiviral Proteases by Forming Biomolecular Condensates

open access: yesAdvanced Science, Volume 13, Issue 1, 5 January 2026.
Upon rice viral infection, the insect vector activates the Toll–MyD88–Dorsal signaling cascade, inducing i‐type lysozyme (Lyz‐I1) expression. Lyz‐I1 functions as an antiviral protease through its conserved catalytic dyad Glu/Asp (E/D), mediating cleavage of viral proteins at specific Lys (K) residues.
Yu Du   +5 more
wiley   +1 more source

Porin‐Independent Uptake of Small Molecule Antibiotics Facilitated by Escherichia coli Outer Membrane Vesicles

open access: yesBiotechnology and Bioengineering, Volume 123, Issue 1, Page 235-244, January 2026.
We demonstrate that bacterial outer membrane vesicles (OMVs) can enhance antibiotic delivery into Gram‐negative bacteria by bypassing porin‐dependent uptake. Encapsulation of imipenem in OMVs significantly increased its effectiveness against multidrug‐resistant clinical isolates, highlighting OMVs as a promising platform for overcoming permeability ...
Meishan Wu   +3 more
wiley   +1 more source

Chlamydiaphage φCPG1 Capsid Protein Vp1 Inhibits Chlamydia trachomatis Growth via the Mitogen-Activated Protein Kinase Pathway

open access: yesViruses, 2016
Chlamydia trachomatis is the most common cause of curable bacterial sexually transmitted infections worldwide. Although the pathogen is well established, the pathogenic mechanisms remain unclear.
Yuanli Guo   +6 more
doaj   +1 more source

A stealth adhesion factor contributes to Vibrio vulnificus pathogenicity: Flp pili play roles in host invasion, survival in the blood stream and resistance to complement activation.

open access: yesPLoS Pathogens, 2019
The tad operons encode the machinery required for adhesive Flp (fimbrial low-molecular-weight protein) pili biogenesis. Vibrio vulnificus, an opportunistic pathogen, harbors three distinct tad loci.
Tra-My Duong-Nu   +8 more
doaj   +1 more source

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