Results 71 to 80 of about 3,572 (201)

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

, 2015
The AIM2 inflammasome detects double-stranded DNA in the cytosol and induces caspase-1-dependent pyroptosis as well as release of the inflammatory cytokines interleukin 1β (IL-1β) and IL-18.
Dick, Mathias, Mathias S Dick, Anton, Leonie, Sébastien Dussurgey, Costanzo, Stéphanie, Klaus Pfeffer, Leonie Anton, Henry, Thomas, Thomas Henry, Roland F Dreier, Mélanie Rigard, Rühl, Sebastian, Wallet, Pierre, Masahiro Yamamoto, Broz, Petr, Daniel Degrandi, Meunier, Etienne, Kistner, Anne, Dreier, Roland, Pfeffer, Klaus, Yamamoto, Masahiro, Sebastian Rühl, Dussurgey, Sébastien, Rigard, Mélanie, Etienne Meunier, Pierre Wallet, Stéphanie Costanzo, Dreier, Roland F., Dick, Mathias S., Degrandi, Daniel, Anne Kistner, Petr Broz   +31 more
core   +1 more source

Insect I‐Type Lysozymes Function as Antiviral Proteases by Forming Biomolecular Condensates

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Upon rice viral infection, the insect vector activates the Toll–MyD88–Dorsal signaling cascade, inducing i‐type lysozyme (Lyz‐I1) expression. Lyz‐I1 functions as an antiviral protease through its conserved catalytic dyad Glu/Asp (E/D), mediating cleavage of viral proteins at specific Lys (K) residues.
Yu Du, Yuqing Xiao, Manman Hu, Jinhua Yang, You Li, Taiyun Wei   +5 more
wiley   +1 more source

Porin‐Independent Uptake of Small Molecule Antibiotics Facilitated by Escherichia coli Outer Membrane Vesicles

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 235-244, January 2026.
We demonstrate that bacterial outer membrane vesicles (OMVs) can enhance antibiotic delivery into Gram‐negative bacteria by bypassing porin‐dependent uptake. Encapsulation of imipenem in OMVs significantly increased its effectiveness against multidrug‐resistant clinical isolates, highlighting OMVs as a promising platform for overcoming permeability ...
Meishan Wu, Rachael M. Harrower, Ziang Li, Angela C. Brown   +3 more
wiley   +1 more source

Mechanistic Insights Into Protein Aggregation Inhibition by Green‐Synthesized Silver Nanoparticles: A Study on Human Lysozyme

IET Nanobiotechnology, Volume 2026, Issue 1, 2026.
A characteristic of many neurodegenerative disorders, such as Parkinson’s and Alzheimer’s, is amyloidogenic protein aggregation, for which there are currently no proven cures. Aging, mutation, and physiological stress can cause proteins to deviate from their natural folding patterns, potentially leading to the formation of hazardous protein aggregates.
Md. Tauqir Alam, Mohd. Ahmar Rauf, Arman Khan, Rizwan Hussain, Anbazhagan Veerappan   +4 more
wiley   +1 more source

Synergistic Activity of Fosfomycin, Ciprofloxacin, and Gentamicin Against Escherichia coli and Pseudomonas aeruginosa Biofilms

Frontiers in Microbiology, 2019
Gram-negative (GN) rods cause about 10% periprosthetic joint infection (PJI) and represent an increasing challenge due to emergence of antimicrobial resistance.
Lei Wang, Lei Wang, Mariagrazia Di Luca, Tamta Tkhilaishvili, Tamta Tkhilaishvili, Andrej Trampuz, Andrej Trampuz, Mercedes Gonzalez Moreno, Mercedes Gonzalez Moreno   +8 more
doaj   +1 more source

Rapid evaluation of bacteriolysis of Listeria innocua and L. welshimeri strains isolated from foods

, 2005
This study was performed to determine the bacteriolytic extent of 10 strains of Listeria innocua and 9 strains of L. welshimeri isolated from foods. Bacteriolysis was measured at 650 nm by spectrophotometer. For this purpose, late exponential phase cells

core  

Characterisation of a Novel Jumbo Lytic Aeromonas dhakensis Bacteriophage P19 and Its Endolysin

Microbial Biotechnology, Volume 19, Issue 1, January 2026.
A jumbo, lytic myovirus phage P19 against multidrug‐resistant (MDR) Aeromonas dhakensis was isolated from river water. P19 demonstrated robust lytic activity, high thermal and pH stability (pH 6–10, up to 60°C), and no genes associated with lysogeny, virulence or antimicrobial resistance. ORF_358 of P19 encodes for T4‐type lysozyme.
Farhat Ansari, Vandan Nagar
wiley   +1 more source

Quantitative Studies on Immune Bacteriolysis II. The Role of Lysozyme in Immune Bacteriolysis

Quantitative Studies on Immune Bacteriolysis II. The Role of Lysozyme in Immune Bacteriolysis
Tanigawa, Yutaka, Takubo, Masuo, Satani, Mutsumi, Inoue, Kozo, Amano, Tsunehisa   +4 more
openaire   +1 more source

Video_9_Dual Inhibitory Activity of Petroselinic Acid Enriched in Fennel Against Porphyromonas gingivalis.AVI

, 2022
Increasing evidence has shown that a major periodontal pathobiont, Porphyromonas gingivalis, triggers oral dysbiosis leading to deterioration not only of periodontal health, but also of several systemic conditions.
Ryoma Nakao (107115), Nanami Yoshino (12565465), Tsuyoshi Ikeda (665475)   +2 more
core   +1 more source

Bacteriocins as a Promising Antimicrobial Strategy Against Multidrug‐Resistant Pathogens: Mechanisms of Action, Applications in Human and Animal Health, and the Food Industry

BioMed Research International, Volume 2026, Issue 1, 2026.
The global rise of antimicrobial resistance has significantly increased the difficulty treating infectious agents, creating an urgent need for alternative therapeutic strategies. In this context, bacteriocins have emerged as a promising solution, offering a potential alternative to conventional antibacterial therapies.
Abdo Megra Geda, Aregash Wendimu Tumebo, Solomon Lulie Abey, Gashaw Enbiyale Kasse, Abraham Belete Temesgen, Zerihun Getie Wassie, Baisakhi Banerjee   +6 more
wiley   +1 more source