Results 141 to 150 of about 373,043 (334)
Advanced Science, EarlyView.A Cas12a@MnO2 nanosponge (hMNS) nanoprobe is engineered to overcome the intracellular delivery and kinetic barrier of the conventional CRISPR/Cas12a system via GSH‐responsive release and Mn2⁺‐enhanced trans‐cleavage. It enables preamplification‐free detection of mRNA with single‐cell sensitivity, differentiation of mRNA expression between breast cancer
Wen‐jing Liu +3 more
wiley +1 more source
Advanced Science, EarlyView.Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong +6 more
wiley +1 more source
The Promising Viral Threat to Bacterial Resistance: The Uncertain Patentability of Phage Therapeutics and the Necessity of Alternative Incentives [PDF]
, 2014 Bacteriophages, or “phages,” are a category of highly adept and adaptable viruses that can infect and kill bacteria. With concerns over the burgeoning antibiotic-resistance crisis looming in recent years, scientists and policymakers have expressed a ...
Todd, Kelly
core +1 more source
A mutant bacteriophage evolved to infect resistant bacteria gained a broader host range [PDF]
, 2019 Michal Habusha +3 more
openalex +1 more source
Advanced Science, EarlyView.Polymeric carriers provide versatile platforms for nucleic acid delivery. This review introduces a novel perspective inspired by protein structural organization to explore structure–function relationships of polymeric carriers, highlighting requirements of different nucleic acid payloads.
Hanieh Moradian +3 more
wiley +1 more source
Experimental phage therapy of burn wound infection : difficult first steps [PDF]
, 2014 Antibiotic resistance has become a major public health problem and the antibiotics pipeline is running dry. Bacteriophages (phages) may offer an ‘innovative’ means of infection treatment, which can be combined or alternated with antibiotic therapy and ...
De Vos, Daniel +8 more
core
Molecular assembly and structure of the bacteriophage T4 tail [PDF]
, 2016 Fumio Arisaka +3 more
openalex +1 more source
Publisher Correction: Safety of bacteriophage therapy in severe Staphylococcus aureus infection [PDF]
, 2020 Aleksandra Petrović Fabijan +11 more
openalex +1 more source
Advanced Science, EarlyView.BRIGHT is a newly developed live‐cell imaging system that integrates cascade amplification with background denoising through the bivalent binding capability and antigen‐dependent stability of a bivalent fluorescent nanobody targeting ALFA peptides.
Lei Feng +9 more
wiley +1 more source
Genes affecting progression of bacteriophage P22 infection in Salmonella identified by transposon and single gene deletion screens [PDF]
, 2018 Kaitlynne A. Bohm +7 more
openalex +1 more source