Results 131 to 140 of about 355,018 (412)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

High-Throughput Bacteriophage Testing with Potency Determination: Validation of an Automated Pipetting and Phage Drop-Off Method

Biomedicines
The development of bacteriophages (phages) as active pharmaceutical ingredients for the treatment of patients is on its way and regulatory agencies are calling for reliable methods to assess phage potency.
Nicolas Dufour, Raphaëlle Delattre, Laurent Debarbieux   +2 more
doaj   +1 more source

EFFECTS OF BACTERIOPHAGE SUPPLEMENTED DIET ON INTESTINAL BENEFICIARY MICROFLORA AND PRODUCTIVE PERFORMANCE OF BROILER [PDF]

, 2022
A Thesis Submitted to the Department of Poultry Science Sher-e-Bangla Agricultural University, Dhaka In Partial fulfillment of the requirements for the degree of MASTER OF SCIENCE (MS) IN POULTRY SCIENCEThe Experiment was done to investigate the
NAIN, MD.ZULKAR
core  

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

Targeted bacteriophage T4 nanoparticles reverse HIV-1 latency in human T cell line models

iScience
Summary: A major barrier for HIV-1 eradication is the latent virus reservoir containing stably integrated and silent proviruses in CD4+ T cells. Targeted reactivation and removal of this latent reservoir is a potential strategy for HIV-1 cure, but ...
Himanshu Batra, Jingen Zhu, Swati Jain, Neeti Ananthaswamy, Marthandan Mahalingam, Pan Tao, Camille Lange, Shawn Hill, Chaojie Zhong, Mary F. Kearney, Haitao Hu, Frank Maldarelli, Venigalla B. Rao   +12 more
doaj   +1 more source

Safety Studies of Pneumococcal Endolysins Cpl-1 and Pal

Viruses, 2018
Bacteriophage-derived endolysins have gained increasing attention as potent antimicrobial agents and numerous publications document the in vivo efficacy of these enzymes in various rodent models. However, little has been documented about their safety and
Marek Harhala, Daniel C. Nelson, Paulina Miernikiewicz, Ryan D. Heselpoth, Beata Brzezicka, Joanna Majewska, Sara B. Linden, Xiaoran Shang, Aleksander Szymczak, Dorota Lecion, Karolina Marek-Bukowiec, Marlena Kłak, Bartosz Wojciechowicz, Karolina Lahutta, Andrzej Konieczny, Krystyna Dąbrowska   +15 more
doaj   +1 more source

A metagenomic approach to characterize temperate bacteriophage populations from Cystic Fibrosis and non-Cystic Fibrosis bronchiectasis patients

, 2015
Pseudomonas aeruginosa (Pa), normally a soil commensal, is an important opportunistic pathogen in Cystic Fibrosis (CF) and non-Cystic Fibrosis Bronchiectasis (nCFBR).
Bourke, Stephen, Smith, Darren L., Anthony eDe Soyza, Cowley, Lauren A., Perry, J. D. (John), Holt, Giles S., Francesca Louise Claire Everest, Stephen eBourke, Darren L. Smith, Tariq, M. A. (Mohammad), Smith, Darren, Stephen eCummings, Holt, Giles, Clare V. Lanyon, Cowley, Lauren, Jeremy J Barr, Bourke, Stephen J., Barr, Jeremy J., Mohammad Adnan Tariq, Bridge, Simon H., Cummings, Stephen, Perry, John, Audrey Perry, Jeremy J. Barr, Barr, Jeremy, Francesca L. C. Everest, Stephen J. Bourke, Bridge, Simon, Simon H. Bridge, Audrey ePerry, Anthony De Soyza, Simon Harwood Bridge, Stephen P. Cummings, John D. Perry, Tariq, Mohammad, Darren Lee Smith, Everest, Francesca, John D Perry, Giles Samuel Holt, Lauren A. Cowley, Lanyon, Clare, Mohammad A. Tariq, Everest, F. L. C. (Francesca), Giles S. Holt, de Soyza, Anthony, Perry, Audrey, Lauren eCowley, Clare Veronica Lanyon   +47 more
core   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Bacterial pathogens in fish and aquaculture systems in Kenya

Academia Biology
The rising global demand for high-quality animal protein has driven the rapid expansion of aquaculture, which is now responsible for 51% of global fish production.
Ivy J. Mutai, Barack Nyanswi, Eric Omori Omwenga, Auleria Ajiambo Apopo, Irene Kokushubila Lweikiza, Victor Irungu Mwangi, Michael Mugo, Felix Mwai, Mary A. Opiyo, Zipporah Gichana, Justus Nyongesa Opondo, Jael Apondi Obiero, Tabitha Wangari Nyoike, Joseph Mwangi, Abraham Ochieng, Atunga Nyachieo   +15 more
doaj   +1 more source

Perspectives of Phage–Eukaryotic Cell Interactions to Control Epstein–Barr Virus Infections

Frontiers in Microbiology, 2018
Recently, leading medical journals emphasized the importance of further studies on the potential application of bacterial viruses (phages) for the treatment of antibiotics-resistant infections outlining the present status of the therapy and perspectives ...
Andrzej Górski, Andrzej Górski, Andrzej Górski, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Ewa Jończyk-Matysiak, Beata Weber-Dąbrowska, Beata Weber-Dąbrowska, Natalia Bagińska, Jan Borysowski   +10 more
doaj   +1 more source