Results 111 to 120 of about 282,905 (301)

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

Asymmetric Single‐Atom Catalysts Govern Diffusible and Non‐Diffusible Non‐Radical Pathways for Selective Degradation of Antibiotic Resistance Genes

Advanced Science, EarlyView.
Asymmetric single‐atom metal‐nitrogen‐carbon catalysts modulate the non‐radical pathway during peroxymonosulfate (PMS) activation. A fundamental contrast was revealed between diffusible singlet oxygen (1O2) and non‐diffusible electron‐transfer pathways (ETP) in antibiotic resistance gene (ARG) degradation.
Chen Gao, Jun Sun, Liang Zhang, Litao Lin, Zongfeng Wan, Bingcai Pan, Sheng Tang   +6 more
wiley   +1 more source

Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis [PDF]

, 2009
In all organisms, the protein machinery responsible for the replication of DNA, the replisome, is faced with a directionality problem. The antiparallel nature of duplex DNA permits the leading-strand polymerase to advance in a continuous fashion, but ...
Richardson, Charles C.,, Takahashi, Masateru, Vanoijen, Antoine M., Hamdan, Samir M., Joseph J. Loparo, Loparo, Joseph J., Richardson, Charles C., Takahashi, Masateru,, Oijen, Antoine M. van, Oijen, Antoine M. van,, Loparo, Joseph J.,, Antoine M. van Oijen, Samir M. Hamdan, Masateru Takahashi, Hamdan, Samir M.,, Charles C. Richardson   +15 more
core   +3 more sources

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Bacterial pathogens in fish and aquaculture systems in Kenya

Academia Biology
The rising global demand for high-quality animal protein has driven the rapid expansion of aquaculture, which is now responsible for 51% of global fish production.
Ivy J. Mutai, Barack Nyanswi, Eric Omori Omwenga, Auleria Ajiambo Apopo, Irene Kokushubila Lweikiza, Victor Irungu Mwangi, Michael Mugo, Felix Mwai, Mary A. Opiyo, Zipporah Gichana, Justus Nyongesa Opondo, Jael Apondi Obiero, Tabitha Wangari Nyoike, Joseph Mwangi, Abraham Ochieng, Atunga Nyachieo   +15 more
doaj   +1 more source

Continuous Evolution System Based on Toxin–Antitoxin System Combined with Base Deaminase Accelerates the In Vivo Modification of Target Proteins

Advanced Science, EarlyView.
The promoted Escherichia coli‐assisted continuous evolution (PEACE) system operates through a stringent three step genetic circuit: target gene mutation via a deaminase–T7 RNA polymerase (T7 RNAP) fusion, coupling variant function to antitoxin expression, and growth based selection of surviving cells.
Xinyu Zhang, Zhanzhi Liu, Ying Xu, Mingjing Sun, Guangzhen Zhou, Deming Rao, Xiaoqian Chen, Sheng Wang, Zhigang Li, Yan Huang, Jing Wu   +10 more
wiley   +1 more source

Function of bacteriophage orf recombinasesin genetic exchange [PDF]

, 2006
Recombination events in bacteriophages frequently occur by illegitimate exchange at short tracts of sequence homology, enabling these viruses to acquire novel genes and serve as vehicles for horizontal gene transfer.
Reed, Patricia
core  

EFFECTS OF BACTERIOPHAGE SUPPLEMENTED DIET ON INTESTINAL BENEFICIARY MICROFLORA AND PRODUCTIVE PERFORMANCE OF BROILER [PDF]

, 2022
A Thesis Submitted to the Department of Poultry Science Sher-e-Bangla Agricultural University, Dhaka In Partial fulfillment of the requirements for the degree of MASTER OF SCIENCE (MS) IN POULTRY SCIENCEThe Experiment was done to investigate the
NAIN, MD.ZULKAR
core  

Toward Material‐Specific Peptides From in Silico Guided Peptide Engineering to Target PET in the Presence of PS

Advanced Science, EarlyView.
This work presents a computational–experimental strategy to engineer material‐binding peptides toward polymer specificity. Molecular dynamics simulations identified residues driving polystyrene binding, enabling targeted substitutions that greatly reduced polystyrene affinity while preserving PET binding.
Julian Luka, Marian Bienstein, Jonas Berger, Ulrich Schwaneberg   +3 more
wiley   +1 more source

Bacteriophage genomics [PDF]

Current Opinion in Microbiology, 2008
The past three years have seen an escalation in the number of sequenced bacteriophage genomes with more than 500 now in the NCBI phage database, representing a more than threefold increase since 2005. These span at least 70 different bacterial hosts, with two-thirds of the sequenced genomes of phages representing only eight bacterial hosts.
openaire   +2 more sources