Results 101 to 110 of about 336,180 (306)

Targeted bacteriophage T4 nanoparticles reverse HIV-1 latency in human T cell line models

iScience
Summary: A major barrier for HIV-1 eradication is the latent virus reservoir containing stably integrated and silent proviruses in CD4+ T cells. Targeted reactivation and removal of this latent reservoir is a potential strategy for HIV-1 cure, but ...
Himanshu Batra, Jingen Zhu, Swati Jain, Neeti Ananthaswamy, Marthandan Mahalingam, Pan Tao, Camille Lange, Shawn Hill, Chaojie Zhong, Mary F. Kearney, Haitao Hu, Frank Maldarelli, Venigalla B. Rao   +12 more
doaj   +1 more source

Safety Studies of Pneumococcal Endolysins Cpl-1 and Pal

Viruses, 2018
Bacteriophage-derived endolysins have gained increasing attention as potent antimicrobial agents and numerous publications document the in vivo efficacy of these enzymes in various rodent models. However, little has been documented about their safety and
Marek Harhala, Daniel C. Nelson, Paulina Miernikiewicz, Ryan D. Heselpoth, Beata Brzezicka, Joanna Majewska, Sara B. Linden, Xiaoran Shang, Aleksander Szymczak, Dorota Lecion, Karolina Marek-Bukowiec, Marlena Kłak, Bartosz Wojciechowicz, Karolina Lahutta, Andrzej Konieczny, Krystyna Dąbrowska   +15 more
doaj   +1 more source

454-Pyrosequencing: A Molecular Battiscope for Freshwater Viral Ecology [PDF]

, 2010
Viruses, the most abundant biological entities on the planet, are capable of infecting organisms from all three branches of life, although the majority infect bacteria where the greatest degree of cellular diversity lies.
Ackermann, Alan J. McCarthy, Darren L. Smith, David J. Rooks, Foster, Heather E. Allison, James E. McDonald, Margulies, Martin J. Woodward, Ryan, Sambrook, Warren, White, Wilson   +13 more
core   +3 more sources

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Bacterial pathogens in fish and aquaculture systems in Kenya

Academia Biology
The rising global demand for high-quality animal protein has driven the rapid expansion of aquaculture, which is now responsible for 51% of global fish production.
Ivy J. Mutai, Barack Nyanswi, Eric Omori Omwenga, Auleria Ajiambo Apopo, Irene Kokushubila Lweikiza, Victor Irungu Mwangi, Michael Mugo, Felix Mwai, Mary A. Opiyo, Zipporah Gichana, Justus Nyongesa Opondo, Jael Apondi Obiero, Tabitha Wangari Nyoike, Joseph Mwangi, Abraham Ochieng, Atunga Nyachieo   +15 more
doaj   +1 more source

Perspectives of Phage–Eukaryotic Cell Interactions to Control Epstein–Barr Virus Infections

Frontiers in Microbiology, 2018
Recently, leading medical journals emphasized the importance of further studies on the potential application of bacterial viruses (phages) for the treatment of antibiotics-resistant infections outlining the present status of the therapy and perspectives ...
Andrzej Górski, Andrzej Górski, Andrzej Górski, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Ewa Jończyk-Matysiak, Beata Weber-Dąbrowska, Beata Weber-Dąbrowska, Natalia Bagińska, Jan Borysowski   +10 more
doaj   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Replication of plasmids derived from Shiga toxinconverting bacteriophages in starved Escherichia coli [PDF]

, 2011
The pathogenicity of Shiga toxin-producing Escherichia coli (STEC) depends on the expression of stx genes that are located on lambdoid prophages. Effective toxin production occurs only after prophage induction, and one may presume that replication of the
Nadratowska-Wesołowska, Beata, Nejman, Bożena, Szalewska-Pałasz, Agnieszka, Węgrzyn, Alicja, Węgrzyn, Grzegorz   +4 more
core  

Sequence Variability of P2-Like Prophage Genomes Carrying the Cytolethal Distending Toxin V Operon in Escherichia coli O157 [PDF]

, 2013
Cytolethal distending toxins (CDT) are potent cytotoxins of several Gram-negative pathogenic bacteria, including Escherichia coli, in which five types (CDT-I to CDT-V) have been identified so far.
Allué-Guardia, Appleyard, Asadulghani, Asakura, B. Horvath, Bielaszewska, Bielaszewska, Bielaszewska, Birnboim, Comayras, D. Svab, De Rycke, Friedrich, G. Maroti, Garcia, Hayashi, Hertman, Hinenoya, I. Toth, Iguchi, Janka, Jinadasa, Johnson, Karch, Kim, Kulasekara, Larina, Nesić, Nilsson, Nilsson, Nougayrède, Odegrip, Orth, Osek, Oswald, Pickett, Pérès, Scott, Sváb, Sváb, Tóth, Tóth, Tóth, U. Dobrindt, Woodcock   +44 more
core   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source