Results 91 to 100 of about 282,905 (301)

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

When bacteriophages encounter macrophages during their journey through the human body

Frontiers in Cellular and Infection Microbiology
The increasing problem of antibiotic resistance is one of the most significant threats to global public health, contributing to higher mortality rates, prolonged hospitalizations, and rising healthcare costs.
Martyna Cieślik, Magdalena Gębicka, Michał Wójcicki, Andrzej Górski, Andrzej Górski, Ewa Jończyk-Matysiak   +5 more
doaj   +1 more source

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

Advanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao, Tao Yang, Rui Wang, Hui‐Da Li, Xiao‐Yu Zhang, Feng Cheng, Ying Liu, Jian‐Hua Wang, Ting Yang, Chuanbin Mao   +9 more
wiley   +1 more source

The Effect of Bacteriophage Preparations on Intracellular Killing of Bacteria by Phagocytes

Journal of Immunology Research, 2015
Intracellular killing of bacteria is one of the fundamental mechanisms against invading pathogens. Impaired intracellular killing of bacteria by phagocytes may be the reason of chronic infections and may be caused by antibiotics or substances that can be
Ewa Jończyk-Matysiak, Marzanna Łusiak-Szelachowska, Marlena Kłak, Barbara Bubak, Ryszard Międzybrodzki, Beata Weber-Dąbrowska, Maciej Żaczek, Wojciech Fortuna, Paweł Rogóż, Sławomir Letkiewicz, Krzysztof Szufnarowski, Andrzej Górski   +11 more
doaj   +1 more source

Phage Therapy in Poland – a Centennial Journey to the First Ethically Approved Treatment Facility in Europe

Frontiers in Microbiology, 2020
Although phage discovery is an unquestionable merit of the English bacteriologist Frederick W. Twort and the Canadian–French microbiologist Félix d’Hérelle, who both discovered phages over 100 years ago, the Polish history of phage studies also dates ...
Maciej Żaczek, Beata Weber-Dąbrowska, Beata Weber-Dąbrowska, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Marzanna Łusiak-Szelachowska, Andrzej Górski, Andrzej Górski   +8 more
doaj   +1 more source

A tail-like assembly at the portal vertex in intact herpes simplex type-1 virions [PDF]

, 2012
Herpes viruses are prevalent and well characterized human pathogens. Despite extensive study, much remains to be learned about the structure of the genome packaging and release machinery in the capsids of these large and complex double-stranded DNA ...
Rixon Frazer J., Schmid Michael F., Rixon, Frazer J., Bhella David, David Bhella, Ryan H. Rochat (129683), Hecksel, Corey W., Rochat, Ryan H., Hecksel Corey W., Chiu Wah, Bhella, David, Chiu, Wah, Wah Chiu, Michael F. Schmid (129681), Michael F Schmid, Rochat Ryan H., Corey W Hecksel, Schmid, Michael F., David Bhella (129684), Frazer J. Rixon (129686), Frazer J Rixon, Corey W. Hecksel (129682), Ryan H Rochat, Wah Chiu (129685)   +23 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Protecting Newborns from Multidrug-Resistant Infections: The Emerging Role of Bacteriophages

Viruses
Newborns may suffer from dangerous bacterial infections caused by life-threatening multi-drug resistant pathogens. Thus, despite bactericidal capabilities of antibiotics, microorganisms are known to circumvent this therapy, and a new, more effective type
Olaf Bajrak, Andrzej Górski, Ewa Jończyk-Matysiak   +2 more
doaj   +1 more source

Bacteriophages as potential treatment for urinary tract infections

Frontiers in Microbiology, 2016
Background: Urinary tract infections (UTIs) are among the most prevalent microbial diseases and their financial burden on society is substantial. The continuing increase of antibiotic resistance worldwide is alarming so that well-tolerated, highly ...
Wilbert eSybesma, Reinhard eZbinden, Nino eChanishvili, Mzia eKutateladze, Archil eChkhotua, Aleksandre eUjmajuridze, Ulrich eMehnert, Thomas eKessler   +7 more
doaj   +1 more source

The Effect of Infection with Bacteriophage on the Electrokinetic Potential of Rhizobium leguminosarum [PDF]

, 1959
SUMMARY: Infection with bacteriophage increased the electrophoretic mobility of pea nodule bacteria (Rhizobium leguminosarum) at pH 7, suggesting an alteration of the bacterial surface.
Kleczkowski, J., Kleczkowski, A.
core   +1 more source