Results 71 to 80 of about 285,810 (297)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Bacteriophage Assembly [PDF]

Viruses, 2011
Bacteriophages have been a model system to study assembly processes for over half a century. Formation of infectious phage particles involves specific protein-protein and protein-nucleic acid interactions, as well as large conformational changes of assembly precursors.
Aksyuk, Anastasia A., Rossmann, Michael G.   +1 more
openaire   +3 more sources

Comparative genomics of Shiga toxin encoding bacteriophages [PDF]

, 2012
Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, lifethreatening disease and Stx toxin is an integral virulence factor.
Alan J McCarthy, Darby Alistair C, Alistair C Darby, Allison Heather E, Rooks David J, Rooks, David, Smith, Darren, Paul CM Fogg, Thomson, Nicholas, David J Rooks, Smith Darren L, McCarthy Alan J, McCarthy, Alan, Heather E Allison, Darren L Smith, Allison, Heather, Fogg Paul CM, Nick R Thomson, Fogg, Paul, Darby, Alistair, Thomson Nick R   +20 more
core   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Bacteriophage gene database

, 2022
Bacteriophage gene ...
Wenfa Ng
core   +2 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

The OMM12 mice: a decade of dissecting host-microbiome interactions

Gut Microbes
Humans and their associated microbes form a multifaceted ecosystem. Gaining mechanistic insight into this system necessitates reductionist models integrating ecological and immunological dimensions.
Devon E. Conti, Laurent Debarbieux, Caroline Henrot   +2 more
doaj   +1 more source

Draft genome sequence of Bacteriophage vB_Eco_swan01 [PDF]

, 2017
Bacteriophage vB_Eco_swan01 was isolated from an ornamental pool using Escherichia coli MG1655 as the host. Bacteriophage vB_Eco_swan01 has limited similarity with other known phages at the nucleotide level and likely represents a new bacteriophage ...
Scanlan, David J., Michniewski, Slawomir, Millard, Andrew D., Redgwell, Tamsin, Slawomir Michniewski, Tamsin Redgwell, Andrew D. Millard, David J. Scanlan   +7 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Molecular diversity and evolutionary dynamics of phage receptor binding proteins in Staphylococcus aureus: implications for phage therapy and resistance

Scientific Reports
Phage–host interactions are defined by the molecular specificity of receptor-binding proteins (RBPs), which determine the efficacy of infection and the host range.
C. S. VinodKumar, B. S. Prasad, A. Arunkumar, Ishfaq Nabi Najar, Aarti Singh, J. K. Veni Emilda, R. Venkatesh, Vikram Sivaji, V. L. Jayasimha, Suresh Basavaraj Arakera, Suneeta Kalasuramath, N. Ramesh, Balaji Veeraraghavan   +12 more
doaj   +1 more source