Results 81 to 90 of about 282,905 (301)

Molecular diversity and evolutionary dynamics of phage receptor binding proteins in Staphylococcus aureus: implications for phage therapy and resistance

Scientific Reports
Phage–host interactions are defined by the molecular specificity of receptor-binding proteins (RBPs), which determine the efficacy of infection and the host range.
C. S. VinodKumar, B. S. Prasad, A. Arunkumar, Ishfaq Nabi Najar, Aarti Singh, J. K. Veni Emilda, R. Venkatesh, Vikram Sivaji, V. L. Jayasimha, Suresh Basavaraj Arakera, Suneeta Kalasuramath, N. Ramesh, Balaji Veeraraghavan   +12 more
doaj   +1 more source

A metagenomic approach to characterize temperate bacteriophage populations from Cystic Fibrosis and non-Cystic Fibrosis bronchiectasis patients [PDF]

, 2015
Pseudomonas aeruginosa (Pa), normally a soil commensal, is an important opportunistic pathogen in Cystic Fibrosis (CF) and non-Cystic Fibrosis Bronchiectasis (nCFBR).
Bourke, Stephen, Smith, Darren L., Anthony eDe Soyza, Cowley, Lauren A., Perry, J. D. (John), Holt, Giles S., Francesca Louise Claire Everest, Stephen eBourke, Darren L. Smith, Tariq, M. A. (Mohammad), Smith, Darren, Stephen eCummings, Holt, Giles, Clare V. Lanyon, Cowley, Lauren, Jeremy J Barr, Bourke, Stephen J., Barr, Jeremy J., Mohammad Adnan Tariq, Bridge, Simon H., Cummings, Stephen, Perry, John, Audrey Perry, Jeremy J. Barr, Barr, Jeremy, Francesca L. C. Everest, Stephen J. Bourke, Bridge, Simon, Simon H. Bridge, Audrey ePerry, Anthony De Soyza, Simon Harwood Bridge, Stephen P. Cummings, John D. Perry, Tariq, Mohammad, Darren Lee Smith, Everest, Francesca, John D Perry, Giles Samuel Holt, Lauren A. Cowley, Lanyon, Clare, Mohammad A. Tariq, Everest, F. L. C. (Francesca), Giles S. Holt, de Soyza, Anthony, Perry, Audrey, Lauren eCowley, Clare Veronica Lanyon   +47 more
core   +1 more source

Conformational Switching of Proteins on Material Surfaces Enabled by Peptide‐Oriented Adsorption

Advanced Functional Materials, EarlyView.
Responsive biointerfaces could be achieved using conformationally responsive proteins; however, their interconversion can be lost upon surface adsorption. Herein, we demonstrate that the incorporation a Au binding peptide into calmodulin allows for binding control on Au wherein the protein retains conformational switching. This capability was confirmed
Sakthirupini Ramamurthy, Kyle B. Meerbott, Lorenzo Travaglini, Garima S. Dobhal, Artur Sawicki, Marc R. Knecht, Tiffany R. Walsh, Dominic J. Glover   +7 more
wiley   +1 more source

Comprehensive Approaches to Combatting Acinetobacter baumannii Biofilms: From Biofilm Structure to Phage-Based Therapies

Antibiotics
Acinetobacter baumannii—a multidrug-resistant (MDR) pathogen that causes, for example, skin and soft tissue wounds; urinary tract infections; pneumonia; bacteremia; and endocarditis, particularly due to its ability to form robust biofilms—poses a ...
Ilona Grygiel, Olaf Bajrak, Michał Wójcicki, Klaudia Krusiec, Ewa Jończyk-Matysiak, Andrzej Górski, Joanna Majewska, Sławomir Letkiewicz   +7 more
doaj   +1 more source

Lab‐in‐a‐Tube System Integrating Hierarchically Wrinkled Electrodes and DNAzyme‐Functionalized Beads for Diagnosis of Clostridioides difficile Infection

Advanced Materials, EarlyView.
The point‐of‐care diagnosis of Clostridioides difficile infection remains challenging due to reliance on slow culture and amplification‐based methods. A lab‐in‐a‐tube electrochemical biosensor integrating DNAzymes, antifouling magnetic beads, and a hierarchically structured flow cell enables amplification‐ and culture‐free detection directly in stool ...
Survanshu Saxena, Soyeon Lee, Youngeun Choi, Jonathan L'Heureux‐Hache, Jiaying Liu, Sadman Sakib, Sara M. Imani, Marek Smieja, Yingfu Li, Todd Hoare, Leyla Soleymani   +10 more
wiley   +1 more source

Comparative genomics of Shiga toxin encoding bacteriophages [PDF]

, 2012
Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, lifethreatening disease and Stx toxin is an integral virulence factor.
Alan J McCarthy, Darby Alistair C, Alistair C Darby, Allison Heather E, Rooks David J, Rooks, David, Smith, Darren, Paul CM Fogg, Thomson, Nicholas, David J Rooks, Smith Darren L, McCarthy Alan J, McCarthy, Alan, Heather E Allison, Darren L Smith, Allison, Heather, Fogg Paul CM, Nick R Thomson, Fogg, Paul, Darby, Alistair, Thomson Nick R   +20 more
core   +1 more source

Smart Antibacterial Coatings: Harnessing Bacterial Redox Activity for Infection Control

Advanced Materials Interfaces, EarlyView.
In this study, we have shown that ceftazidime‐loaded poly(3,4‐ethylenedioxythiophene) (PEDOT@CAZ) functions as a smart, redox‐responsive antibacterial coating that couples bacterial electrical activity with localized antibiotic delivery. Shewanella oneidensis and Pseudomonas aeruginosa induced distinct redox responses in PEDOT, reflecting their ...
Abdullah, Szymon Smołka, Kamran Ayaz, Sara Shakibania, Sajida Maryam, Taral Patel, Roman Turczyn, Ewa Zabłocka‐Godlewska, Katarzyna Krukiewicz   +8 more
wiley   +1 more source

Characterization of bacteriophage vB_KleM_KB2 possessing high control ability to pathogenic Klebsiella pneumoniae

Scientific Reports, 2023
Klebsiella pneumoniae is a widespread pathogen of several human diseases. The emergence of multidrug-resistant K. pneumoniae makes the treatment of these diseases a significant challenge.
Qin Peng, Zimeng Ma, Qing Han, Fangfang Xiang, Lushuang Wang, Yibin Zhang, Yuting Zhao, Jianing Li, Yaxin Xian, Yihui Yuan   +9 more
doaj   +1 more source

The role of regulated clinical trials in the development of bacteriophage therapeutics. [PDF]

, 2012
Antibiotic resistance is now recognized as a major, global threat to human health and the need for the development of novel antibacterial therapies has become urgent. Lytic bacteriophages (phages) targeting individual bacterial pathogens have therapeutic
McConville, ML, Burrowes, BH, Enright, Mark, Harper, DR, Parracho, HM   +4 more
core   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source