Results 151 to 160 of about 261,858 (336)

Bacteriophage–Host Interactions and the Therapeutic Potential of Bacteriophages

Viruses
Healthcare faces a major problem with the increased emergence of antimicrobial resistance due to over-prescribing antibiotics. Bacteriophages may provide a solution to the treatment of bacterial infections given their specificity. Enzymes such as endolysins, exolysins, endopeptidases, endosialidases, and depolymerases produced by phages interact with ...
Leon M. T. Dicks, Wian Vermeulen
openaire   +3 more sources

Engineering DNA Origami Captors for TGFβ1 Sequestration to Enhance Tumor Immune Modulation and Therapy

Advanced Science, EarlyView.
Programmable DNA framework captors effectively deplete circulatingtransforming growth factor‐β1 (TGFβ1) through fast systemic clearance and reshape the tumor immune microenvironment, alleviating immunosuppression to inhibit tumor progression. Abstract Efficient modulation of pivotal immune‐regulatory molecules to leverage the tumor microenvironment ...
Xiao Chen, Dunfang Liu, Jiahui Jin, Han Yao, Yao Sheng, Yarong Liu, Jingwei Sun, Yang Yang   +7 more
wiley   +1 more source

Direct Sequencing of 5‐Methylcytosine and 5‐Hydroxymethylcytosine at Single‐Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease

Advanced Science, EarlyView.
This study introduces two orthogonal sequencing methods, CMD1‐Deaminase sequencing (CD‐seq) and CMD1‐TET bisulfite sequencing (CT‐seq), that enable direct, independent detection of 5mC. Using these approaches together with ACE‐seq or TAB‐seq for 5hmC identification, the study reveals a significant reduction in 5hmC, but not 5mC, in the hippocampus of ...
Zi‐Xin Wang, Faying Chen, Bao‐Dan He, Fan‐Chen Wang, Jiaxue Cha, Yu Song, Wei‐Ying Meng, Wan‐Yue Zou, Yu‐Tao Fu, Shu‐Xia Sun, Zhi‐Yan Sun, Hao‐Ming Jiang, Ke‐Yao Zhao, Yujun Hou, Jiejun Shi, Jian‐Huang Xue   +15 more
wiley   +1 more source

Single‐Molecule Protein Profiling Using Nanopores and Dimeric Aptamer‐Modified DNA Carriers

Angewandte Chemie, EarlyView.
We developed a nanopore‐based biosensor for single‐molecule protein profiling using aptamer‐modified DNA carrier dimerization strategy, enabling selective and ultrasensitive detection of proteins and protein complexes. This approach promises advances in early‐stage clinical diagnostics and precision medicine.
Xiaoyi Wang, Yaxian Liu, Ren Ren, Joshua B. Edel, Aleksandar P. Ivanov   +4 more
wiley   +2 more sources

Resistance, mechanism, and fitness cost of specific bacteriophages for Pseudomonas aeruginosa

mSphere
The bacteriophage is an effective adjunct to existing antibiotic therapy; however, in the course of bacteriophage therapy, host bacteria will develop resistance to bacteriophages, thus affecting the efficacy.
Luozhu Feng, Huanchang Chen, Changrui Qian, Yining Zhao, Weixiang Wang, Yan Liu, Mengxin Xu, Jianming Cao, Tieli Zhou, Qing Wu   +9 more
doaj   +1 more source

Bacteriophage Phenomena in Fermentative Microorganisms

, 1955
Takichi Kaneko, Sadao IWANO, Kakuo KITAHARA   +2 more
openalex   +2 more sources

CRISPR Screening Reveals a Novel Role for FOXH1 in Regulating Pluripotency of Porcine Embryonic Stem Cells

Advanced Science, EarlyView.
This study performs dual CRISPR screens in pEPSCs. Fitness screening identifies essential genes for viability, while FACS‐based screening uncovers core pluripotency factors. It highlights FOXH1 as a key regulator that maintains the stem cell state through a dual‐action mechanism: preserving pluripotency by enhancing chromatin accessibility and ...
Peng Su, Linhui Wu, Delong Li, Wenting Song, Dagang Tao, Liang Liu, Qi Wang, Manxin Gao, Tian Xu, Xin Liu, Shengsong Xie, Xia Zhang, Jilong Zhou, Yi‐Liang Miao   +13 more
wiley   +1 more source

Serological Classification of Bacteriophages Active Against Lactic Streptococci1 [PDF]

, 1954
H. H. Wilkowske, F. E. Nelson, C. E. Parmelee   +2 more
openalex   +1 more source

Fluorescence Guided Surgery in Gastric Cancer: What Do We Have and What Can We Do?

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background and Objective Fluorescence imaging has emerged as a valuable adjunct in gastric surgery, enhancing resection precision and oncologic outcomes. However, the use of indocyanine green (ICG) remains controversial due to uncertainties in efficacy and administration. A lack of standardized protocols persists.
Chun Zhuang, Han‐Kwang Yang
wiley   +1 more source

ON THE REPORTED STIMULATION OF BACTERIOPHAGE SYNTHESIS BY INDOLE-3-ACETIC ACID

, 1947
Seymour S. Cohen, Catherine B. Fowler
openalex   +1 more source