Results 41 to 50 of about 17,136 (170)

A modular phage vector platform for targeted photodynamic therapy of Gram-negative bacterial pathogens

iScience, 2023
Summary: Growing antibiotic resistance has encouraged the revival of phage-inspired antimicrobial approaches. On the other hand, photodynamic therapy (PDT) is considered a very promising research domain for the protection against infectious diseases. Yet,
Annapaola Petrosino, Roberto Saporetti, Francesco Starinieri, Edoardo Sarti, Luca Ulfo, Luca Boselli, Andrea Cantelli, Andrea Morini, Suleman Khan Zadran, Giampaolo Zuccheri, Zeno Pasquini, Matteo Di Giosia, Luca Prodi, Pier Paolo Pompa, Paolo Emidio Costantini, Matteo Calvaresi, Alberto Danielli   +16 more
doaj   +1 more source

A plug-and-play aptamer diagnostic platform based on linear dichroism spectroscopy

Frontiers in Chemistry, 2023
A plug-and-play sandwich assay platform for the aptamer-based detection of molecular targets using linear dichroism (LD) spectroscopy as a read-out method has been demonstrated.
Haydn A. Little, Haydn A. Little, Aysha Ali, Aysha Ali, Jake G. Carter, Jake G. Carter, Matthew R. Hicks, Timothy R. Dafforn, James H. R. Tucker   +8 more
doaj   +1 more source

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

Advanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao, Tao Yang, Rui Wang, Hui‐Da Li, Xiao‐Yu Zhang, Feng Cheng, Ying Liu, Jian‐Hua Wang, Ting Yang, Chuanbin Mao   +9 more
wiley   +1 more source

Early stage evaluation of colon cancer using tungsten disulfide quantum dots and bacteriophage nano-biocomposite as an efficient electrochemical platform

Cancer Nanotechnology, 2022
Background Recently, biosensors have become popular analytical tools for small analytes due to their high sensitivity and wide analytical range. In the present work, development of a novel biosensing method based on tungsten disulfide quantum dots (WS2 ...
Ramin Pourakbari, Mehdi Yousefi, Balal Khalilzadeh, Mahsa Haddad Irani-nezhad, Alireza Khataee, Leili Aghebati-Maleki, Alireza Soleimanian, Amin Kamrani, Forough Chakari-Khiavi, Rozita Abolhasan, Morteza Motallebnezhad, Farhad Jadidi-Niaragh, Bahman Yousefi, Hossein Samadi Kafil, Mohammad Hojjat-Farsangi, Mohammad-Reza Rashidi   +15 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Mapping of Promoter Sites on the Genome of Bacteriophage M13 [PDF]

European Journal of Biochemistry, 1976
With the aid of transcription studies on restriction fragments of bacteriophage M13 DNA it has been demonstrated that at least eight promoter sites are located on the M13 genome. Five of these promoters initiate the synthesis of RNA chains which contain at their 5′‐terminal end pppG (G promoters), while the other three promoters initiate RNA chains ...
L, Edens, P, van Wezenbeek, N H, Konings, J G, Schoenmakers   +3 more
openaire   +2 more sources

Quantifying Structure‐Dependent Rigidity of 3D DNA Origami Boxes

Advanced Intelligent Systems, EarlyView.
We investigate the mechanical stability of a hollow 3D DNA origami box during assembly using liquid AFM imaging and finite element simulations. As structural completeness increases from flat sheets through intermediate assemblies to a closed box, rigidity improves.
Judith Zubia‐Aranburu, Reza Zadegan, Jens Vinge Nygaard, Jørgen Kjems, Ramesh Subramani, Mingdong Dong   +5 more
wiley   +1 more source

Scalable Separation and Purification of M13‐Bacteriophage‐Derived Particles Containing Artificial Single‐Stranded DNA Produced by Escherichia coli

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Single‐stranded DNA (ssDNA) solutions are promising innovations shaping the future of genetic research and medical therapies. In principle, biotechnological mass production of ssDNA can be achieved using Escherichia coli in a high‐cell density fed‐batch process by secreting phagemid particles derived from the filamentous M13 bacteriophages ...
Nathalie Hafner, Wiebke Winkler, Maximilian N. Honemann, Hendrik Dietz, Dirk Weuster‐Botz   +4 more
wiley   +1 more source

Detection of Micrometer-Sized Virus Aerosols by Using a Real-Time Bioaerosol Monitoring System

Biosensors
This study investigates a real-time handheld bioaerosol monitoring system for the detection of biological particles using UV-LED and light-induced fluorescence technology.
Hyunsoo Seo, Young-Su Jeong, Jaekyung Bae, Kibong Choi, Moon-Hyeong Seo   +4 more
doaj   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source