Results 71 to 80 of about 103,146 (258)

Nanobody‐Mediated c‐MYC Degradation Inhibits Tumor Cell Progression

MedComm, Volume 7, Issue 4, April 2026.
A cell‐permeable nanobody strategy was developed to target the intrinsically disordered oncoprotein c‐MYC. A synthetic nanobody, M4, binds the central PEST region of c‐MYC (241–263) and promotes c‐MYC degradation by enhancing Thr58 phosphorylation. Conjugation of M4 to a cell‐penetrating peptide (CPP) generates CPM4, which efficiently accumulates in ...
Yuanyuan Xue, Hao Jiang, Zhaoyun Zong, Xiaolin Tian, Zelong Miao, Ting Li, Yali Wei, Haiteng Deng   +7 more
wiley   +1 more source

Uptake and processing of modified bacteriophage M13 in mice: implications for phage display.

Virology, 2002
Internalization and degradation of filamentous bacteriophage M13 by a specific target cell may have major consequences for the recovery of phage in in vivo biopanning of phage libraries.
T. J. Molenaar, I. Michon, Sonja A M de Haas, T. V. van Berkel, J. Kuiper, E. Biessen   +5 more
semanticscholar   +1 more source

Non‐Viral Cytokine‐Inducible SH2 Containing Protein Locus‐Specific Integrated Fibroblast Activation Protein Alpha‐Targeting Chimeric Antigen Receptor T Cells Achieve Potent Antitumor Efficacy in Glioblastoma

MedComm, Volume 7, Issue 4, April 2026.
FAPα is a dual target on glioblastoma cells and perivascular cells. Using a high‐affinity anti‐FAPα nanobody, we generated CISH‐KO FAPα‐CAR‐T cells via non‐viral CRISPR–Cas9 integration. These cells demonstrated enhanced proliferation and superior antitumor efficacy in patient‐derived organoids and orthotopic mouse models compared to conventional CAR‐T
Xin Dong, Yao Sun, Yuetong Guo, Jiao Wang, Fei Wang, Ziming Wang, Ruizhen Li, Fei Xie, Tingting Tan, Baijie Cheng, Ronghan Huang, Shu Zhang, Xiaotong Lin, Zhaoze Guo, Hubing Wu, Hao Wu, Xubiao Zhang, Guozhu Xie   +17 more
wiley   +1 more source

Novel Strategy towards Efficiency Enhancement of Flexible Optoelectronic Devices with Engineered M13 Bacteriophage

Small Structures
Plasmonic nanostructures, which exhibit notable localized surface plasmon resonance (LSPR) properties, are a promising approach for improving the efficiency of fiber‐shaped dye‐sensitized solar cells (FDSSCs) and flexible organic light‐emitting diodes ...
Jae Ho Kim, Geonguk Kim, Sung‐Jo Kim, Yu Bhin Kim, Jae‐Wook Kang, Jin Woo Choi, Jin‐Woo Oh, Myungkwan Song   +7 more
doaj   +1 more source

Genetically modified bacteriophages [PDF]

, 2016
Phages or bacteriophages, viruses that infect and replicate inside bacteria, are the most abundant microorganisms on earth. The realization that antibiotic resistance poses a substantial risk to the world’s health and global economy is revitalizing phage
Grigonyte, Aurelija M., Jaramillo, Alfonso, MacDonald, Paul, Sagona, Antonia P.   +3 more
core   +1 more source

Construction, Characterization, and Application of a Nonpathogenic Virus-like Model for SARS-CoV-2 Nucleocapsid Protein by Phage Display

Toxins, 2022
With the outbreak and spread of COVID-19, a deep investigation of SARS-CoV-2 is urgent. Direct usage of this virus for scientific research could provide reliable results and authenticity.
Yuting Wu, Bing Liu, Zhiwei Liu, Pengjie Zhang, Xihui Mu, Zhaoyang Tong   +5 more
doaj   +1 more source

Improved single-swab sample preparation for recovering bacterial and phage DNA from human skin and wound microbiomes. [PDF]

, 2019
BackgroundCharacterization of the skin and wound microbiome is of high biomedical interest, but is hampered by the low biomass of typical samples. While sample preparation from other microbiomes (e.g., gut) has been the subject of extensive optimization,
Chen, Irene A, Deacon, John M, Kim, Colin Y, Verbanic, Samuel   +3 more
core   +1 more source

Three-dimensional structure of a cloning vector. X-ray diffraction studies of filamentous bacteriophage M13 at 7 A resolution.

Journal of Molecular Biology, 1992
Filamentous bacteriophage M13 is a single-stranded DNA phage about 65 A in diameter and 9300 A long. X-ray diffraction studies of magnetically oriented fibers of native, mercury and iodine-labeled phage particles have been used to determine the ...
M. Glucksman, S. Bhattacharjee, L. Makowski   +2 more
semanticscholar   +1 more source

Probing molecular mechanisms of M13 bacteriophage adhesion [PDF]

Communications Chemistry, 2019
AbstractM13 bacteriophages can provide a versatile platform for nanobiotechnology because of their unique biological and physicochemical properties. Polypeptides on their surfaces can be finely tuned on demand through genetic engineering, enabling tailored assembly of multiple functional components through specific interactions.
Chanoong Lim, Jina Ko, Dasom Jeon, Yoojung Song, Jinwoo Park, Jungki Ryu, Dong Woog Lee   +6 more
openaire   +2 more sources

Rational Design of Optical Single‐Walled Carbon Nanotube‐Based Nanosensors with Biological Recognition Elements

Advanced Sensor Research, Volume 5, Issue 3, March 2026.
This Review focuses on assessing and providing perspective on the field of rationally‐designed optical sensors constructed with single‐walled carbon nanotubes. The literature is reviewed and evaluated for SWCNT‐based sensors constructed with biomolecular recognition elements, including proteins, peptides, and oligonucleotides, as well as their methods ...
Amelia K. Ryan, Atara Israel, Maria Celina Stefoni, Catarina Ferraz, Ryan M. Williams   +4 more
wiley   +1 more source