Results 231 to 240 of about 44,922 (302)

Pharmacokinetics and pharmacodynamics of bacteriophage therapy: a review with a focus on multidrug-resistant Gram-negative bacterial infections. [PDF]

Clin Microbiol Rev
Siopi M, Skliros D, Paranos P, Koumasi N, Flemetakis E, Pournaras S, Meletiadis J.   +6 more
europepmc   +1 more source

Evaluation of the effectiveness of etiotropic therapy with linezolid and bacteriophage in a mouse model for staphylococcal infection

Maria Kornienko, В. Б. Кузин, Н. К. Абдраймова, RB Gorodnichev, Egor Shitikov   +4 more
openalex   +1 more source

Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational Methods

MedComm, Volume 7, Issue 2, February 2026.
This review explores the recent advancements in applying computational methods to optimize mRNA vaccines, with a primary focus on improvements in sequence design and delivery systems. ABSTRACT mRNA medicine is an emerging therapeutic approach that utilizes messenger RNA to synthesize functional proteins directly within target cells.
Ruichu Gu, Duanmiao Si, Dingwei Lei, Xiaoxue Xie, Yongge Li, Han Wen   +5 more
wiley   +1 more source

Tetravalent antibodies are more potent and efficacious erythropoiesis‐stimulating agents than erythropoietin in vivo

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Recent studies have shown that tetravalent antibodies are potent and efficacious agonists of the erythropoietin (EPO) receptor (EPOR) both in vitro and in vivo. To identify antibody‐based erythropoiesis‐stimulating agents (ESAs) with therapeutic potential, we evaluated various tetravalent antibody formats for EPOR agonism and key biophysical ...
Jarrett J. Adams, Levi L. Blazer, Jacky Chung, Minoo Karimi, Taylor Davidson, Bailey Blair, Carlos Waddle, Craig A. Hokanson, Heather A. Bruce, Alexander U. Singer, Eva‐Maria Tombak, Kiira Gildemann, Nele Tamberg, Kaja Kiiver, Mart Ustav Jr, Yue Ma, Luigi Colombo, Lily Jun‐Shen Huang, Stephen W. Michnick, Orson W. Moe, Sachdev S. Sidhu   +20 more
wiley   +1 more source

Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings, Serbülent Ünsal, Mathieu Rappas, Matthew Barnes, Maria Waldhoer, Ben Holland, Martin Culka   +6 more
wiley   +1 more source

Bacteriophage therapy reduces Staphylococcus aureus in a porcine and human ex vivo burn wound infection model. [PDF]

Antimicrob Agents Chemother
Molendijk MM, Boekema BKHL, Lattwein KR, Vlig M, Bode LGM, Koopmans MPG, Verbon A, de Graaf M, van Wamel WJB.   +8 more
europepmc   +1 more source

Bacteriophage Therapy in GIT Infections – A Clinical Review

Fahad Ali Noori, Muhammad Saqlain Mushtaq, Muhammad Saad Latif, Syed Damin Abbas Hamdani, Mustafeez Mujtaba Babar   +4 more
openalex   +2 more sources

Bioswitches: Towards programmable, on‐demand control of therapeutic proteins

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Benedict Wolf, Jan Mathony, Dominik Niopek   +2 more
wiley   +1 more source

Novel Wide‐Spectrum Virucidal Lipid Nanoparticles

Small, Volume 22, Issue 7, 2 February 2026.
POSTAN is a novel broad‐spectrum antiviral nanoparticle that combines safety with potent virucidal activity. Composed of biocompatible lipids, it mimics heparan sulfate proteoglycans and lipid rafts exploited by viruses, thereby dismantling viral envelopes and blocking replication.
Yugo Araújo Martins, Louise Bondeelle, Arnaud Charles‐Antoine Zwygart, Thais Melquiades de Lima, Juliano de Paula Souza, Han Kang Tee, Fernando Chahud, Eurico de Arruda Neto, Francesco Stellacci, Renata Fonseca Vianna Lopez, Caroline Tapparel   +10 more
wiley   +1 more source

Bacteriophage therapy plus fecal microbiota transplantation to treat recurrent urinary tract infection (rUTI): a case series

McCallin S, Classen A, Lieberknecht S, Abdula F, Dugas S, Gross O, Koliwer-Brandl H, Lassen S, Scheidegger J, Dunne M, Kahles A, Eigler J, Farowski F, Higgins PG, Milek S, Chemych O, Kessler T, Vehreschild M, Leitner L, Biehl L.   +19 more
europepmc   +1 more source